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Binding affinity towards human HTR2C in an in vitro assay with cellular components measured by radioactivity method
Assay data:123 Active, 1 Activity ≤ 1 nM, 48 Activity ≤ 1 µM, 1199 Tested
SummaryRelated BioAssays by Target
Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration
Assay data:103 Active, 70 Activity ≤ 1 µM, 317 Tested
Binding affinity towards human HTR2A in an in vitro assay with cellular components measured by membrane filtration
Assay data:140 Active, 4 Activity ≤ 1 nM, 75 Activity ≤ 1 µM, 414 Tested
Binding affinity towards human HRH2 in an in vitro assay with cellular components measured by membrane filtration
Assay data:61 Active, 32 Activity ≤ 1 µM, 283 Tested
Binding affinity towards human HRH1 in an in vitro assay measured by filtration
Assay data:151 Active, 1 Activity ≤ 1 nM, 90 Activity ≤ 1 µM, 1239 Tested
Binding affinity towards human CHRM5 in an in vitro assay with cellular components measured by membrane filtration
Assay data:19 Active, 13 Activity ≤ 1 µM, 117 Tested
Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting
Assay data:155 Active, 74 Activity ≤ 1 µM, 927 Tested
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2
Assay data:6069 Active, 5332 Activity ≤ 1 µM, 575118 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approved drugs and bioactive compounds
Assay data:1106 Active, 14 Activity ≤ 1 nM, 6478 Activity ≤ 1 µM, 7578 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
High-throughput drug toxicity screening in the BPDCN cell line Gen2.2
Assay data:29 Activity ≤ 1 nM, 425 Activity ≤ 1 µM, 1910 Tested
SummaryCompounds, activity ≤ 1 µM
Effective free therapeutic plasma concentration (EFTPC): the concentration of unbound compund in the blood plasma at therapeutic dose (mean of range)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation (Rep 2)
Assay data:53 Activity ≤ 1 nM, 332 Activity ≤ 1 µM, 2023 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (3D7) proliferation
Assay data:59 Activity ≤ 1 nM, 281 Activity ≤ 1 µM, 2023 Tested
qHTS profiling for inhibitors of Plasmodium falciparum (3D7) proliferation
Assay data:16 Activity ≤ 1 nM, 124 Activity ≤ 1 µM, 633 Tested
qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen
Assay data:583 Active, 15 Activity ≤ 1 nM, 316 Activity ≤ 1 µM, 10486 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins
Assay data:12 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting
Assay data:12 Active, 12 Activity ≤ 1 µM, 15 Tested
DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)
Assay data:49 Active, 12 Activity ≤ 1 nM, 45 Activity ≤ 1 µM, 871 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)
Assay data:103 Active, 2 Activity ≤ 1 nM, 77 Activity ≤ 1 µM, 871 Tested
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
Assay data:117 Active, 3 Activity ≤ 1 nM, 83 Activity ≤ 1 µM, 871 Tested
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