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p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS cell viability counter screen
Assay data:214 Active, 153 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS cell viability counter screen
Assay data:300 Active, 138 Activity ≤ 1 µM, 9667 Tested
Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Inhibition of human PHGDH by fluorescence based analysis
Assay data:15 Active, 12 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Metallo-beta-lactamase NDM-1 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as substrate hydrolysis using imipenem as substrate by spectrometric analysis
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of NDM-1 (unknown origin)
Assay data:17 Active, 13 Activity ≤ 1 µM, 45 Tested
Anticancer activity against mouse 4T1 cells assessed as cell growth inhibition by MTS assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant SARS-CoV-2 Main protease expressed in Escherichia coli BL21 (DE3) using Mca-AVLQSGFR-K(Dnp)K as substrate by fluorescence based assay
n Vitro Biochemical Test of Inhibiting SARM1 Enzyme Activity Assay from US Patent US20230414581: "SARM1 ENZYME ACTIVITY INHIBITOR AND USE THEREOF IN NEURODEGENERATIVE DISEASES"
Assay data:10 Active, 8 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: luciferase reporter gene qHTS assay in human keratinocytes
Assay data:1099 Active, 1 Activity ≤ 1 nM, 143 Activity ≤ 1 µM, 9667 Tested
Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: qHTS cell viability counter screen in human keratinocytes
Assay data:683 Active, 47 Activity ≤ 1 µM, 9667 Tested
MAGL Enzyme Inhibition Assay from US Patent US11753371: "Disulfiram derivatives as ALDH1A1 and MAGL inhibitors"
Assay data:12 Active, 4 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: OPM1_PLB cell viability assay
Assay data:896 Active, 18 Activity ≤ 1 nM, 320 Activity ≤ 1 µM, 1912 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: OCIMY5_PLB cell viability assay
Assay data:980 Active, 10 Activity ≤ 1 nM, 428 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: OCIMY7_PLB cell viability assay
Assay data:828 Active, 37 Activity ≤ 1 nM, 590 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS34_JCRB cell viability assay
Assay data:581 Active, 20 Activity ≤ 1 nM, 384 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS28PE_JCRB cell viability assay
Assay data:751 Active, 8 Activity ≤ 1 nM, 310 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: LP1_DSMZ cell viability assay
Assay data:486 Active, 24 Activity ≤ 1 nM, 280 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: MM1R_ATCC cell viability assay
Assay data:822 Active, 12 Activity ≤ 1 nM, 319 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: MM1S_ATCC cell viability assay
Assay data:1053 Active, 13 Activity ≤ 1 nM, 437 Activity ≤ 1 µM, 1911 Tested
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