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Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Cytotoxicity against human IMR-32 cells assessed as lethal concentration measured after 24 hrs by cell titer glo assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Cytotoxicity against human CHP-134 cells assessed as lethal concentration measured after 24 hrs by cell titer glo assay
Inhibition of beta5 proteasome (unknown origin)
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of beta 1 proteasome (unknown origin)
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: luciferase reporter gene qHTS assay in human keratinocytes
Assay data:1099 Active, 1 Activity ≤ 1 nM, 143 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: qHTS cell viability counter screen in human keratinocytes
Assay data:683 Active, 47 Activity ≤ 1 µM, 9667 Tested
Proteasome Inhibitory Activity from US Patent US11542283: "Synthesis of peptide borate ester compound and use thereof"
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Antiproliferative activity against human MM1.R cells assessed as inhibition of cell proliferation incubated for 72 hrs by XTT assay
Assay data:5 Active, 2 Activity ≤ 1 µM, 5 Tested
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation incubated for 72 hrs by XTT assay
Assay data:4 Active, 2 Activity ≤ 1 µM, 5 Tested
Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell proliferation incubated for 72 hrs by XTT assay
Assay data:4 Active, 2 Activity ≤ 1 µM, 8 Tested
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence assay
Assay data:25 Active, 1 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 34 Tested
Inhibition of human 20S proteasome beta5 subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence intensity assay
Assay data:31 Active, 15 Activity ≤ 1 µM, 42 Tested
Inhibition of human 20S immunoproteasome beta1 subunit using Ac-nLPnLD-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence intensity assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 5 Tested
Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence intensity assay
Assay data:42 Active, 41 Activity ≤ 1 µM, 42 Tested
Inhibition of human 20S immunoproteasome beta-1i subunit using (Ac-PAL)2R110 as substrate preincubated for 2 hrs followed by substrate addition and measured after 1 hr by fluorescence intensity assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of proteasome (unknown origin)
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of 20S proteasome beta1 subunit (unknown origin) using Z-LLE-AMC as flurogenic substrate measured after 1 hr by fluorescence based analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of 20S proteasome beta2 subunit (unknown origin) using Boc-LRR-AMC as flurogenic substrate measured after 1 hr by fluorescence based analysis
Cytotoxicity against HEK293 cells incubated for 24 hrs
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