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Inhibition of anti-CD3 and anti-CD28 monoclonal antibody-stimulated IL2 secretion in human CD4+ T cells
Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influx
Assay data:23 Active, 23 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of IRK
Assay data:24 Active, 20 Activity ≤ 1 µM, 26 Tested
Inhibition of ITK in presence of 1 mM ATP
Assay data:24 Active, 24 Activity ≤ 1 µM, 26 Tested
Binding affinity to ITK by DELFIA-based molecular assay
Assay data:26 Active, 9 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 26 Tested
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