BioAssays, activity concentration at/below 1 uM for PubChem Compound ( - PubChem BioAssay - NCBI

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Select item 19137911.

Selectivity interaction (Enzymatic assay) EUB0000685a PIK3C3

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913791

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19137892.

Selectivity interaction (Enzymatic assay) EUB0000685a PIK3C2B

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913789

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19131363.

Affinity Biochemical interaction (Enzymatic fluorescence polarization assay) EUB0000685a PIK3CG

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913136

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19131354.

Affinity Biochemical interaction (Enzymatic fluorescence polarization assay) EUB0000685a PIK3CD

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913135

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19131345.

Affinity Biochemical interaction (Enzymatic fluorescence polarization assay) EUB0000685a PIK3CB

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913134

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19131336.

Affinity Biochemical interaction (Enzymatic fluorescence polarization assay) EUB0000685a PIK3CA

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913133

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19127207.

Affinity Phenotypic Cellular interaction (MesoScale Discovery assay (AKT phoshorylation in MCF 7 cells)) EUB0000685a PIK3CG

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912720

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19127198.

Affinity Phenotypic Cellular interaction (MesoScale Discovery assay (AKT phoshorylation in MCF 7 cells)) EUB0000685a PIK3CD

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912719

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19127189.

Affinity Phenotypic Cellular interaction (MesoScale Discovery assay (AKT phoshorylation in MCF 7 cells)) EUB0000685a PIK3CB

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912718

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191271710.

Affinity Phenotypic Cellular interaction (MesoScale Discovery assay (AKT phoshorylation in MCF 7 cells)) EUB0000685a PIK3CA

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912717

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 189760311.

Inhibition of PI3Kdelta in human B-cells assessed as reduction in CD69 expression preincubated for 1 hr followed by IgM stimulation for 18 hrs by flow cytometry analysis

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1897603

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189759212.

Inhibition of PI3Kalpha H1047R mutant in human HCC1954 cells assessed as reduction in PRAS40 phosphorylation after 24 hrs by electrochemiluminescent assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Assay data:15 Active, 13 Activity ≤ 1 µM, 17 Tested

AID:: 1897592

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189758913.

Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Assay data:36 Active, 27 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 36 Tested

AID:: 1897589

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 180509114.

Biochemical Inhibition Assay from US Patent US10851091: "Benzoxazepin oxazolidinone compounds and methods of use"

Source:: BindingDB

Protein Targets:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; ...
Total:: 4

Assay data:21 Active, 17 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested

AID:: 1805091

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179596215.

p110alpha (Alpha) PI3K Binding Assay from US Patent US10112932: "Benzoxazepin oxazolidinone compounds and methods of use"

Source:: BindingDB

Protein Targets:: Phosphatidylinositol 3-kinase regulatory subunit alpha; ...
Total:: 4

Assay data:20 Active, 17 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested

AID:: 1795962

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 164587716.

Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)

Source:: National Center for Advancing Translational Sciences (NCATS)

Protein Target:: Histone-lysine N-methyltransferase NSD2

Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested

AID:: 1645877

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 164587617.

Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)

Source:: National Center for Advancing Translational Sciences (NCATS)

Protein Target:: Histone-lysine N-methyltransferase NSD2

Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested

AID:: 1645876

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 149159718.

Inhibition of PI3K delta (unknown origin)

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1491597

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 149159619.

Inhibition of PI3K alpha (unknown origin)

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1491596

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 134741220.

qHTS assay to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Counter screen cell viability and HiBit confirmation

Source:: National Center for Advancing Translational Sciences (NCATS)

Protein Target:: Interferon beta

Assay data:347 Active, 1 Activity ≤ 1 nM, 215 Activity ≤ 1 µM, 650 Tested

AID:: 1347412

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

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Target

Proteins (4)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (35)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (17)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (35)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (35)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (20)
BioAssays extracted from the literature
NIH MLP (4)
BioAssays deposited by the NIH Molecular Libraries Program
Other (11)
BioAssays deposited by other experimentalists

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