BioAssays, activity concentration at/below 1 uM for PubChem Compound ( - PubChem BioAssay - NCBI

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Select item 19110741.

Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition incubated for 96 hrs by cell titer glo assay

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1911074

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19110622.

Inhibition of PI3Kdelta in IgM stimulated human Raji cells incubated for 10 mins by AlphaLISA assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1911062

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19110603.

Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate measured after 1 hr in presence of ATP by ADP-glo luminescence assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 1911060

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19110594.

Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate measured after 1 hr in presence of ATP by ADP-glo luminescence assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested

AID:: 1911059

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19110575.

Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate measured after 1 hr in presence of ATP by ADP-glo luminescence assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:30 Active, 29 Activity ≤ 1 µM, 30 Tested

AID:: 1911057

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19110566.

Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 1 hr in presence of ATP by ADP-glo luminescence assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Assay data:26 Active, 16 Activity ≤ 1 µM, 30 Tested

AID:: 1911056

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18003667.

Enzyme Assay from US Patent US8653092: "Tetrahydro-pyrido-pyrimidine derivatives"

Source:: BindingDB

Protein Targets:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; ...
Total:: 2

Assay data:94 Active, 94 Activity ≤ 1 µM, 94 Tested

AID:: 1800366

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 15025718.

Ex-vivo inhibition of PI3Kdelta in po dosed Lewis rat assessed as reduction in anti-IgM/IL4-induced AKT phosphorylation at ser473 residue in whole blood pretreated up to 24 hrs followed by anti-IgM/IL4 stimulation after 10 mins by flow cytometric analysis

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1502571

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 15025679.

Dose normalized Cmax in cynomolgus monkey at 0.3 mg/kg, po by RP-HPLC analysis

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1502567

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 150255110.

Dose normalized Cmax in Sprague-Dawley rat at 30 mg/kg, po by RP-HPLC analysis

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1502551

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 150254711.

Dose normalized Cmax in Sprague-Dawley rat at 3 mg/kg, po by RP-HPLC analysis

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1502547

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 150253612.

Inhibition of DNA-PK (unknown origin) using peptide substrate assessed as reduction in incorporation of radioactive 33p into substrate by liquid scintillation counting method

Source:: ChEMBL

Protein Target:: DNA-dependent protein kinase catalytic subunit

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1502536

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 150253213.

Inhibition of PI3Kdelta in anti-CD3/CD28 stimulated mouse CD4-positive T cells assessed as reduction in T cell differentiation to Th17 cells by measuring IL-17A level after 72 hrs by ELISA

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1502532

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 150253114.

Inhibition of PI3Kdelta in anti-CD3/CD28 stimulated mouse CD4-positive T cells assessed as reduction in T cell differentiation to Th2 cells by measuring IL-13 level after 72 hrs by ELISA

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1502531

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 150253015.

Inhibition of PI3Kdelta in mouse spleen cells assessed as reduction in cell proliferation by measuring [3H]thymidine incorporation by beta counting based mixed lymphocyte reaction assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1502530

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 150252816.

Inhibition of PI3Kdelta in anti-CD3/CD28 stimulated human PBMC derived CD4-positive T cells assessed as reduction in T cell differentiation to Th17 cells by measuring IL-17A level after 72 hrs by ELISA

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1502528

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 150252717.

Inhibition of PI3Kdelta in anti-CD3/CD28 stimulated human PBMC derived CD4-positive T cells assessed as reduction in T cell differentiation to Th2 cells by measuring IL-13 level after 72 hrs by ELISA

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1502527

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 150252618.

Inhibition of PI3Kdelta in anti-CD3 stimulated human PBMC assessed as reduction in cell proliferation by measuring [3H]thymidine incorporation pretreated for 1 hr followed by anti-CD3 addition measured last 16 hrs of 56 hrs incubation by beta counting method

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1502526

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 150252519.

Inhibition of PI3Kdelta in human PBMC assessed as reduction in cell proliferation by measuring [3H]thymidine incorporation measured last 16 hrs of 4 days incubation by beta counting based mixed lymphocyte reaction assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1502525

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 150252420.

Inhibition of PI3Kdelta in 50% rat blood assessed as reduction in anti-IgM stimulated AKT phosphorylation at ser473 residue pretreated for 1.5 hr followed by anti-IgM stimulation after 10 mins by flow cytometric analysis

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1502524

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

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BioActivity

Active Compounds (31)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (31)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (31)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (31)
BioAssays extracted from the literature

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