BioAssays, activity concentration at/below 1 uM for PubChem Compound ( - PubChem BioAssay - NCBI

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Select item 19144391.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000262b TMEM97

Source:: ChEMBL

Protein Target:: Sigma intracellular receptor 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914439

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19144372.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000262b GABRA1

Source:: ChEMBL

Protein Target:: Gamma-aminobutyric acid receptor subunit alpha-1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914437

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19144343.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000262b SIGMAR1

Source:: ChEMBL

Protein Target:: Sigma non-opioid intracellular receptor 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914434

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19144334.

Selectivity interaction (TR-FRET assay) EUB0000262b BCL2

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914433

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19144325.

Selectivity interaction (TR-FRET assay) EUB0000262b BCL2

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914432

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19132366.

Affinity Biochemical interaction (TR-FRET assay) EUB0000262b BCL2L1

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 1

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913236

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19127817.

Affinity Phenotypic Cellular interaction (CellTiter-Glo Luminescent Cell Viability Assay (BCL-XL dependent cell line H146)) EUB0000262b BCL2L1

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912781

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18538518.

Cytotoxicity against human platelets assessed as cell growth inhibition incubated for 24 hrs

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1853851

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 18538509.

Cytotoxicity against human MOLT-4 cells assessed as cell growth inhibition incubated for 72 hrs

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1853850

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 179444710.

GPCRScan assay: inhibition of Sigma 1

Source:: ChEMBL

Protein Target:: Sigma non-opioid intracellular receptor 1

Assay data:20 Active, 13 Activity ≤ 1 µM, 181 Tested

AID:: 1794447

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179444611.

GPCRScan assay: inhibition of Sigma 2

Source:: ChEMBL

Protein Target:: Sigma intracellular receptor 2

Assay data:29 Active, 24 Activity ≤ 1 µM, 181 Tested

AID:: 1794446

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179444412.

GPCRScan assay: inhibition of GABA/PBR

Source:: ChEMBL

Assay data:16 Active, 19 Activity ≤ 1 µM, 181 Tested

AID:: 1794444

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 179205613.

CellTiter-Glo Luminescent Cell Viability Assay (BCL-XL dependent cell line MOLT-4)

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1792056

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 179205514.

CellTiter-Glo Luminescent Cell Viability Assay (BCL-XL dependent cell line H146)

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1792055

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 179197215.

Time-resolved fluorescence energy transfer (TR-FRET) with BCL2

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Active, 3 Activity ≤ 1 µM, 4 Tested

AID:: 1791972

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179197116.

Time-resolved fluorescence energy transfer (TR-FRET) with BCL2L1

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 1

Assay data:1 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 4 Tested

AID:: 1791971

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 129372417.

Cytotoxicity against human Bcl-XL dependant MOLT4 cells by cell based assay

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1293724

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 129372018.

Binding affinity to Bcl-XL (unknown origin) by FRET assay

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 1

Assay data:3 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1293720

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 129371919.

Binding affinity to Bcl-2 (unknown origin) by FRET assay

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1293719

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 116894120.

Binding affinity to MCL1 (unknown origin)

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1168941

Summary Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (25)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (7)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (26)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (26)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (12)
BioAssays extracted from the literature
Other (14)
BioAssays deposited by other experimentalists

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