BioAssays, activity concentration at/below 1 uM for PubChem Compound ( - PubChem BioAssay - NCBI

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Items: 10

Select item 19392761.

Inhibition of Rock2 (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1939276

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19392752.

Induction of disruption of actin stress fibers in human TM1 cells by actin stress fiber assay

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1939275

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19392743.

Induction of disruption of actin stress fibers in PTM cells by actin stress fiber assay

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1939274

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19392734.

Inhibition of Rock2 (unknown origin) by Kinase Glo luminescence assay

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1939273

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19392725.

Inhibition of Rock1 (unknown origin) by Kinase Glo luminescence assay

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 1

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1939272

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18069616.

ROCK-II(h) In Vitro Inhibition Activity from US Patent US11485707: "Deuterated compounds as rock inhibitors"

Source:: BindingDB

Protein Targets:: Rho-associated protein kinase 2; ...
Total:: 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1806961

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 18069607.

ROCK-I(h) In Vitro Inhibition Activity-Method A from US Patent US11485707: "Deuterated compounds as rock inhibitors"

Source:: BindingDB

Protein Targets:: Rho-associated protein kinase 1; ...
Total:: 1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1806960

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 16741738.

Inhibition of human ROCK2 by Kinase-Glo luminescent assay

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1674173

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15641219.

Inhibition of human ROCK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate incubated for 20 mins in presence of [gamma33P]ATP by filter binding method

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1564121

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 156412010.

Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate incubated for 20 mins in presence of [gamma33P]ATP by filter binding method

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1564120

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (10)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (3)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (10)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (10)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (10)
BioAssays extracted from the literature

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