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Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
Assay data:116 Active, 1 Activity ≤ 1 nM, 39 Activity ≤ 1 µM, 1135 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader
Assay data:41 Active, 16 Activity ≤ 1 µM, 1178 Tested
Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:32 Active, 2 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 1197 Tested
Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration
Assay data:195 Active, 66 Activity ≤ 1 µM, 1241 Tested
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:166 Active, 1 Activity ≤ 1 nM, 62 Activity ≤ 1 µM, 1209 Tested
Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
Assay data:80 Active, 18 Activity ≤ 1 µM, 1172 Tested
Displacement of [3H]5-CT from 5-HT1D receptor (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Displacement of [3H]5-CT from 5-HT1B receptor (unknown origin)
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Displacement of [3H]LSD from 5-HT5A receptor (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 4 Tested
Displacement of [3H]carboxytryptamine from recombinant human 5-HT1B receptor expressed in HEK cells by scintillation counting
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Displacement of [3H]GR125743 from recombinant human 5-HT1D receptor expressed in HEK cells by scintillation counting
DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan)
Assay data:60 Active, 30 Activity ≤ 1 µM, 871 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)
Assay data:92 Active, 7 Activity ≤ 1 nM, 74 Activity ≤ 1 µM, 871 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)
Assay data:59 Active, 7 Activity ≤ 1 nM, 45 Activity ≤ 1 µM, 871 Tested
DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)
Assay data:58 Active, 34 Activity ≤ 1 µM, 871 Tested
DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)
Assay data:38 Active, 23 Activity ≤ 1 µM, 871 Tested
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)
Assay data:66 Active, 2 Activity ≤ 1 nM, 45 Activity ≤ 1 µM, 871 Tested
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808)
Assay data:18 Active, 12 Activity ≤ 1 µM, 871 Tested
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)
Assay data:103 Active, 2 Activity ≤ 1 nM, 77 Activity ≤ 1 µM, 871 Tested
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
Assay data:117 Active, 3 Activity ≤ 1 nM, 83 Activity ≤ 1 µM, 871 Tested
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