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Antiviral activity against HIV1 infected in human MT4 cells assessed as inhibition of viral replication
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of HIV-1 integrase DTG-resistant H51Y/R263K double mutant
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of HIV-1 integrase DTG-resistant R263K mutant
Inhibition of HIV-1 integrase DTG-resistant G118R mutant
Inhibition of HIV-1 integrase RAL-resistant G140S/Q148H double mutant
SummaryCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of HIV-1 integrase G140S/Q148K double mutant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
OCT2 Inhibition Assay from US Patent US11548901: "Substituted 1,4-methanopyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections"
Assay data:19 Active, 11 Activity ≤ 1 µM, 23 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US10689399: "Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections"
Inhibition Assay from US Patent US9663528: "Substituted 1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazines and methods for treating viral infections"
Assay data:18 Active, 10 Activity ≤ 1 µM, 22 Tested
Antiviral activity against HIV1 3B
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of HIV integrase strand transfer activity
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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