BioAssays, activity concentration at/below 1 nM for PubChem Compound ( - PubChem BioAssay - NCBI

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Items: 12

Select item 13108021.

Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hr

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:48 Active, 5 Activity ≤ 1 nM, 48 Activity ≤ 1 µM, 50 Tested

AID:: 1310802

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 13108012.

Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hr

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:50 Active, 37 Activity ≤ 1 nM, 50 Activity ≤ 1 µM, 50 Tested

AID:: 1310801

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7421123.

SANGER: Inhibition of human DEL cell growth in a cell viability assay.

Source:: ChEMBL

Assay data:73 Active, 3 Activity ≤ 1 nM, 40 Activity ≤ 1 µM, 129 Tested

AID:: 742112

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 7418554.

SANGER: Inhibition of human SF539 cell growth in a cell viability assay.

Source:: ChEMBL

Assay data:55 Active, 3 Activity ≤ 1 nM, 34 Activity ≤ 1 µM, 137 Tested

AID:: 741855

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 7418475.

SANGER: Inhibition of human SCC-3 cell growth in a cell viability assay.

Source:: ChEMBL

Assay data:32 Active, 1 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 77 Tested

AID:: 741847

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 6428886.

Cytotoxicity against mouse BAF3 cells expressing Tel-ALK after 48 hrs by CellTiter-Glo assay

Source:: ChEMBL

Assay data:23 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 34 Tested

AID:: 642888

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 6250767.

Binding constant for PLK4 kinase domain

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase PLK4

Assay data:33 Active, 2 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 72 Tested

AID:: 625076

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 6249168.

Binding constant for ULK1 kinase domain

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase ULK1

Assay data:19 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 72 Tested

AID:: 624916

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 6248999.

Binding constant for ROS1 kinase domain

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:19 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 72 Tested

AID:: 624899

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 62482510.

Binding constant for BMPR1B kinase domain

Source:: ChEMBL

Protein Target:: Bone morphogenetic protein receptor type-1B

Assay data:25 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 72 Tested

AID:: 624825

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 62474311.

Binding constant for LTK kinase domain

Source:: ChEMBL

Protein Target:: Leukocyte tyrosine kinase receptor

Assay data:29 Active, 1 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 72 Tested

AID:: 624743

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 62474112.

Binding constant for LRRK2(G2019S) kinase domain

Source:: ChEMBL

Protein Target:: Leucine-rich repeat serine/threonine-protein kinase 2

Assay data:25 Active, 2 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 72 Tested

AID:: 624741

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (12)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (12)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (12)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (12)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (9)
BioAssays extracted from the literature
Other (3)
BioAssays deposited by other experimentalists

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