BioAssays, activity concentration at/below 1 nM for PubChem Compound ( - PubChem BioAssay - NCBI

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Select item 19189871.

Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: OCIMY7_PLB cell viability assay

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:828 Active, 37 Activity ≤ 1 nM, 590 Activity ≤ 1 µM, 1912 Tested

AID:: 1918987

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor

Select item 19189742.

Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS21BM_JCRB cell viability assay

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:650 Active, 358 Activity ≤ 1 nM, 751 Activity ≤ 1 µM, 1912 Tested

AID:: 1918974

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor

Select item 19189613.

Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: Karpas417_ECACC cell viability assay

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:508 Active, 171 Activity ≤ 1 nM, 712 Activity ≤ 1 µM, 1912 Tested

AID:: 1918961

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor

Select item 14868194.

Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1486819

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 14846065.

Antiproliferative activity against human U266 cells after 72 hrs by calcein AM staining based fluorescence assay

Source:: ChEMBL

Assay data:12 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 47 Tested

AID:: 1484606

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 14846056.

Antiproliferative activity against human CEM cells after 72 hrs by calcein AM staining based fluorescence assay

Source:: ChEMBL

Assay data:13 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 47 Tested

AID:: 1484605

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 13821477.

Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-MCA as substrate measured for 1 hr by fluorescence assay

Source:: ChEMBL

Protein Target:: Proteasome subunit beta type-5

Assay data:9 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 17 Tested

AID:: 1382147

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 12501538.

Cytotoxicity against human Glioma cells (HF3013) after 72 hrs by CelltiterGlo assay

Source:: ChEMBL

Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested

AID:: 1250153

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 12501529.

Cytotoxicity against human Glioma cells (HF2885) after 72 hrs by CelltiterGlo assay

Source:: ChEMBL

Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1250152

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 125015110.

Cytotoxicity against human Glioma cells (HF2876) after 72 hrs by CelltiterGlo assay

Source:: ChEMBL

Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested

AID:: 1250151

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 125015011.

Cytotoxicity against human Glioma cells (HF2790) after 72 hrs by CelltiterGlo assay

Source:: ChEMBL

Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1250150

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 125014912.

Cytotoxicity against human Glioma cells (HF2476) after 72 hrs by CelltiterGlo assay

Source:: ChEMBL

Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested

AID:: 1250149

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 125014813.

Cytotoxicity against human Glioma cells (HF2381) after 72 hrs by CelltiterGlo assay

Source:: ChEMBL

Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1250148

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 125014714.

Cytotoxicity against human Glioma cells (HF2303) after 72 hrs by CelltiterGlo assay

Source:: ChEMBL

Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested

AID:: 1250147

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 122567015.

Inhibition of proteasome (unknown origin)

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1225670

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 118086216.

Inhibition of human 26S proteasomal catalytic subunit chymotrypsin-like activity using Suc-LLVYaminoluciferin as substrate after 4 hrs by luminescence assay

Source:: ChEMBL

Assay data:3 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1180862

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 115641417.

Growth inhibition of human T47D cells

Source:: ChEMBL

Assay data:5 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 5 Tested

AID:: 1156414

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 115641318.

Growth inhibition of human BT549 cells

Source:: ChEMBL

Assay data:5 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 5 Tested

AID:: 1156413

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 115641019.

Growth inhibition of human MCF7 cells

Source:: ChEMBL

Assay data:5 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 5 Tested

AID:: 1156410

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 115640620.

Growth inhibition of human TK10 cells

Source:: ChEMBL

Assay data:5 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 5 Tested

AID:: 1156406

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

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Target

Proteins (1)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (127)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (127)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (127)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (126)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (54)
BioAssays extracted from the literature
NIH MLP (3)
BioAssays deposited by the NIH Molecular Libraries Program
Other (70)
BioAssays deposited by other experimentalists

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