BioAssays, activity concentration at/below 1 nM for PubChem Compound ( - PubChem BioAssay - NCBI

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Select item 19606631.

Inhibition of GST-tagged human CDK2/Cyclin A2 expressed in baculovirus infected Sf9 cells using 5-FAM-QSPKKG-CONH2 as substrate incubated for 60 mins in presence of ATP

Source:: ChEMBL

Protein Targets:: Cyclin-A2; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960663

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19486372.

Binding affinity to recombinant STK4 (unknown origin) assessed as dissociation constant by DSF assay

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1948637

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19486343.

Binding affinity to recombinant MARK4 (unknown origin) assessed as dissociation constant by DSF assay

Source:: ChEMBL

Protein Target:: MAP/microtubule affinity-regulating kinase 4

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1948634

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19486334.

Binding affinity to recombinant MARK3 (unknown origin) assessed as dissociation constant by DSF assay

Source:: ChEMBL

Protein Target:: MAP/microtubule affinity-regulating kinase 3

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1948633

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19486305.

Binding affinity to recombinant BMP2K (unknown origin) assessed as dissociation constant by DSF assay

Source:: ChEMBL

Protein Target:: BMP-2-inducible protein kinase

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1948630

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19410626.

Inhibition of PKA (unknown origin)

Source:: ChEMBL

Protein Targets:: cAMP-dependent protein kinase catalytic subunit alpha; ...
Total:: 3

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1941062

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19274877.

Cytotoxicity against human HeLa S3 cells measured after 72 hrs

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1927487

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19201438.

Biochemical Assay from US Patent US20240002365: "PYRIDAZINE AND 1,2,4-TRIAZINE DERIVATIVES AS FGFR KINASE INHIBITORS"

Source:: BindingDB

Protein Targets:: Fibroblast growth factor receptor 1; ...
Total:: 4

Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1920143

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18879059.

Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay

Source:: ChEMBL

Assay data:6 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 7 Tested

AID:: 1887905

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 187804610.

Inhibition of recombinant His-tagged human FLT3 D835Y mutant (564 to 958 residues) expressed in baculovirus expression system by LanthaScreen assay

Source:: ChEMBL

Protein Target:: Receptor-type tyrosine-protein kinase FLT3

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1878046

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187804511.

Inhibition of recombinant N-terminal GST/His6-tagged human FLT3 ITD mutant (571 to 993 residues) expressed in insect cells by LanthaScreen assay

Source:: ChEMBL

Protein Target:: Receptor-type tyrosine-protein kinase FLT3

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1878045

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 184678812.

Inhibition of Aurora A (unknown origin) using kemptide as substrate incubated for 50 mins in the presence of ATP by ADP-Glo reagent based luminescence assay

Source:: ChEMBL

Protein Target:: Aurora kinase A

Assay data:2 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1846788

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 184677613.

Inhibition of SYK (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1846776

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 184677514.

Inhibition of Lyn (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1846775

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 184677415.

Inhibition of FLT3 (unknown origin)

Source:: ChEMBL

Protein Target:: Receptor-type tyrosine-protein kinase FLT3

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1846774

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 184677016.

Inhibition of Aurora A(unknown origin)

Source:: ChEMBL

Protein Target:: Aurora kinase A

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1846770

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 184676917.

Inhibition of ALK (unknown origin)

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1846769

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 180199518.

Biochemical Inhibition Assay from US Patent US9206188: "Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors"

Source:: BindingDB

Protein Targets:: Tyrosine-protein kinase ITK/TSK; ...
Total:: 4

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1801995

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 179938319.

in vitro Kinase Assay from Article 10.1021/cb9002865: "In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors."

Source:: BindingDB

Protein Targets:: 5'-AMP-activated protein kinase subunit beta-1; ...
Total:: 7

Assay data:7 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested

AID:: 1799383

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 179759220.

CDK Activity Assay. from Article 10.1074/jbc.M201233200: "Structural basis for Chk1 inhibition by UCN-01."

Source:: BindingDB

Protein Targets:: Cyclin-A2; ...
Total:: 3

Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1797592

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

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Proteins (1)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (361)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (361)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (361)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (348)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (348)
BioAssays extracted from the literature
Other (13)
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