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Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: L363_DSMZ cell viability assay
Assay data:540 Active, 30 Activity ≤ 1 nM, 593 Activity ≤ 1 µM, 1912 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
GILZ gene assays from US Patent US10869929: "Phosphonate linkers and their use to facilitate cellular retention of compounds"
Assay data:22 Active, 9 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Displacement of fluormone labelled GS Red from human recombinant glucocorticoid receptor after 2 hrs by fluorescence polarization assay
Assay data:8 Active, 6 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Transrepression of glucocorticoid receptor in Wistar rat PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins followed by LPS addition measured after 18 hrs by ELISA
Assay data:7 Active, 7 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Transrepression of glucocorticoid receptor in human PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins followed by LPS addition measured after 18 hrs by ELISA
Assay data:23 Active, 17 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 25 Tested
Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediated TRE-LacZ activity after 24 hrs by beta-galactosidase reporter gene assay
Assay data:27 Active, 20 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 29 Tested
qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line in the presence of 0.5 nM R1881: Summary
Assay data:1108 Active, 2 Activity ≤ 1 nM, 246 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway in the presence of an antagonist
Assay data:382 Active, 2 Activity ≤ 1 nM, 175 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line in the presence of 0.5 nM R1881
Assay data:1453 Active, 4 Activity ≤ 1 nM, 292 Activity ≤ 1 µM, 9667 Tested
BK Channel Variant Modulator Selectivity Assay
Assay data:286 Active, 904 Activity ≤ 1 nM, 951 Activity ≤ 1 µM, 951 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary
Assay data:473 Active, 7 Activity ≤ 1 nM, 291 Activity ≤ 1 µM, 10486 Tested
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation
Assay data:74 Activity ≤ 1 nM, 704 Activity ≤ 1 µM, 2023 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
qHTS assay to identify aromatase inhibitors
Assay data:905 Active, 3 Activity ≤ 1 nM, 352 Activity ≤ 1 µM, 10486 Tested
qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line
Assay data:820 Active, 22 Activity ≤ 1 nM, 358 Activity ≤ 1 µM, 10486 Tested
qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line
Assay data:461 Active, 11 Activity ≤ 1 nM, 217 Activity ≤ 1 µM, 10486 Tested
qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary
Assay data:251 Active, 5 Activity ≤ 1 nM, 150 Activity ≤ 1 µM, 10486 Tested
qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway
Assay data:406 Active, 2 Activity ≤ 1 nM, 281 Activity ≤ 1 µM, 10486 Tested
Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-stimulated IL-6 cytokine synthesis
Assay data:20 Active, 3 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
Transactivation activity at glucocorticoid receptor in rat H4II-E cells assessed as induction of tyrosine amino transferase
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
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