BioAssays, activity concentration at/below 1 nM for PubChem Compound ( - PubChem BioAssay - NCBI

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Items: 12

Select item 19131361.

Affinity Biochemical interaction (Enzymatic fluorescence polarization assay) EUB0000685a PIK3CG

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913136

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19131352.

Affinity Biochemical interaction (Enzymatic fluorescence polarization assay) EUB0000685a PIK3CD

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913135

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19131333.

Affinity Biochemical interaction (Enzymatic fluorescence polarization assay) EUB0000685a PIK3CA

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913133

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18975894.

Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Assay data:36 Active, 27 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 36 Tested

AID:: 1897589

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18050915.

Biochemical Inhibition Assay from US Patent US10851091: "Benzoxazepin oxazolidinone compounds and methods of use"

Source:: BindingDB

Protein Targets:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; ...
Total:: 4

Assay data:21 Active, 17 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested

AID:: 1805091

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 17959626.

p110alpha (Alpha) PI3K Binding Assay from US Patent US10112932: "Benzoxazepin oxazolidinone compounds and methods of use"

Source:: BindingDB

Protein Targets:: Phosphatidylinositol 3-kinase regulatory subunit alpha; ...
Total:: 4

Assay data:20 Active, 17 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested

AID:: 1795962

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 14915977.

Inhibition of PI3K delta (unknown origin)

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1491597

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 14915968.

Inhibition of PI3K alpha (unknown origin)

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1491596

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 12808279.

Inhibition of recombinant PI3K alpha (unknown origin) using PIP2 as substrate by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Assay data:19 Active, 12 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested

AID:: 1280827

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 75051510.

Inhibition of PI3Kalpha (unknown origin) assessed as 3,4,5-inositoltriphosphate formation after 30 mins by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Assay data:14 Active, 11 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested

AID:: 750515

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 75048011.

Inhibition of PI3Kgamma (unknown origin)

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 750480

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 75047912.

Inhibition of PI3Kdelta (unknown origin)

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 750479

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (12)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (12)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (12)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (12)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (9)
BioAssays extracted from the literature
Other (3)
BioAssays deposited by other experimentalists

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