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Antitumor activity against human MDA-MB-435 cells xenografted in nude mouse at 15 mg/kg, ip administered 3 times a week for 2 weeks and measured on day 14
Assay data:1 Tested
SummaryPubMed Citation
Antiproliferative activity against human A549 cells assessed as reduction in cell viability at 20 nM in presence of DMBA by MTT assay
High-throughput screening primary assay to identify small molecule activators of human guanylyl cyclase B (GC-B) receptor activity
Assay data:399 Active, 370620 Tested
SummaryCompounds, Active
Increase the activity of the Burkholderia fixLJ 2-component system
Assay data:87 Active, 28704 Tested
SummaryCompounds, ActivePubMed Citation
Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Assay data:281 Active, 189401 Tested
Primary redox qHTS assay for identification of artifact compounds.
Assay data:19 Active, 16 Activity ≤ 1 µM, 5098 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Primary Nanoluciferase (NLuc) qHTS assay for identification of artifact compounds.
Assay data:37 Active, 2 Activity ≤ 1 µM, 5098 Tested
Primary fluorescence-based thiol-reactive (MSTI) qHTS assay for identification of artifact compounds.
Assay data:494 Active, 184 Activity ≤ 1 µM, 5098 Tested
Primary firefly luciferase (FLuc) qHTS assay for identification of artifact compounds.
Assay data:75 Active, 14 Activity ≤ 1 µM, 5098 Tested
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Antiproliferative activity against human A-375 cancer stem cells assessed as reduction in cell proliferation at 0.075 to 10 uM by MTT assay
Antiproliferative activity against mouse B16-F10 cancer stem cells assessed as reduction in cell proliferation at 0.075 to 10 uM by MTT assay
Anticancer activity against human A-375 cells assessed as decrease in tumor spheroids at 1.25 to 2.5 uM measured after 24 hrs
Anticancer activity against mouse B16-F10 cells assessed as decrease in tumor spheroids at 2.5 to 5 uM measured after 24 hrs
Antitumor activity in human MBA-MD-468 cells xenografted in Balb/c mouse assessed as reduction in tumor growth at 2.4 micromol/kg, ip measured after 4 days
Assay data:2 Tested
Binding affinity to human recombinant ACE protein assessed as dissociation constant incubated for 15 mins by MTS binding analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Cytotoxicity against human NCI-H1299 cells assessed as cell viability rescue at 10 uM incubated for 24 hrs in presence of Fecl3 by CCK8 assay
Cytotoxicity against human NCI-H460 cells assessed as cell viability rescue at 10 uM incubated for 24 hrs in presence of Fecl3 by CCK8 assay
Cytotoxicity against human NCI-H226 cells assessed as cell viability rescue at 10 uM incubated for 24 hrs in presence of Fecl3 by CCK8 assay
Inhibition of tubulin (unknown origin) polymerization assessed as reduction in microtubule formation by measuring reduction in absorbance at 10 uM measured every minute for 1 hr in presence of GTP by microplate reader analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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