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p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Assay data:27 Active, 44 Activity ≤ 1 µM, 9667 Tested
Summary
p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Assay data:43 Active, 55 Activity ≤ 1 µM, 9667 Tested
Antiparasitic activity against Toxoplasma gondii RH infected in BALB/c mouse assessed as decrease in IFNgamma level in serum at 20 mg/kg, po administered every 24 hrs for 5 days starting from 24 hrs post infection by ELISA method
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Human kisspeptin (KISS1R) small molecule agonists, calcium flux assay in KISS1R-HEK293 cells: Summary
Assay data:16 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same Project
Human gonadotropin-releasing hormone receptor (GnRHR) small molecule agonists, calcium flux assay in GnRHR-HEK293 cells: Summary
Assay data:109 Active, 9667 Tested
G protein-coupled receptor (GPCR) small molecule agonists, calcium flux assay: HEK293 wild type cell line counter screen
Assay data:47 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
Human kisspeptin (KISS1R) small molecule agonists, calcium flux assay in KISS1R-HEK293 cells
Assay data:55 Active, 2 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 9667 Tested
Human gonadotropin-releasing hormone receptor (GnRHR) small molecule agonists, calcium flux assay in GnRHR-HEK293 cells
Assay data:169 Active, 2 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 9667 Tested
High-throughput screening primary assay to identify small molecule activators of human guanylyl cyclase B (GC-B) receptor activity
Assay data:399 Active, 370620 Tested
SummaryCompounds, Active
Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists, luciferase reporter gene qHTS assay in human keratinocytes: Summary
Assay data:1038 Active, 9667 Tested
Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: luciferase reporter gene qHTS assay in human keratinocytes
Assay data:1099 Active, 1 Activity ≤ 1 nM, 143 Activity ≤ 1 µM, 9667 Tested
Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: qHTS cell viability counter screen in human keratinocytes
Assay data:683 Active, 47 Activity ≤ 1 µM, 9667 Tested
Increase the activity of the Burkholderia fixLJ 2-component system
Assay data:87 Active, 28704 Tested
Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Assay data:281 Active, 189401 Tested
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
Assay data:186 Active, 9 Activity ≤ 1 µM, 11353 Tested
Enzyme Inhibition from US Patent US10870625: "Zwitterionic propargyl-linked antifolates useful for treating bacterial infections"
Assay data:9 Active, 4 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
DHFR Inhibition Assay from Article 10.1016/j.chembiol.2016.11.007: "MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates."
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Enzyme Inhibition Assay from Article 10.1016/j.chembiol.2008.07.013: "Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase."
Assay data:12 Active, 10 Activity ≤ 1 µM, 12 Tested
Thymidylate Synthase (TS) Assay from Article 10.1021/jm900490a: "Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents."
Assay data:19 Active, 19 Activity ≤ 1 µM, 19 Tested
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