BioAssays, Inactive for PubChem Compound (Select 68827) - PubChem BioAssay - NCBI

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Select item 19635961.

Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay

Source:: National Center for Advancing Translational Sciences (NCATS)

Protein Target:: cytochrome P450 3A7 [Homo sapiens]

Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested

AID:: 1963596

Select item 19635852.

p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: Summary

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:70 Active, 12 Activity ≤ 1 µM, 9667 Tested

AID:: 1963585

Select item 19635843.

p53 small molecule agonists, cell-based qHTS assay: Summary

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:212 Active, 41 Activity ≤ 1 µM, 9667 Tested

AID:: 1963584

Select item 19635834.

p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:103 Active, 14 Activity ≤ 1 µM, 9667 Tested

AID:: 1963583

Select item 19635825.

p53 small molecule agonists, cell-based qHTS assay

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:87 Active, 5 Activity ≤ 1 nM, 180 Activity ≤ 1 µM, 9667 Tested

AID:: 1963582

Select item 19635816.

p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter screen

Source:: Tox21

Assay data:213 Active, 2 Activity ≤ 1 nM, 241 Activity ≤ 1 µM, 9667 Tested

AID:: 1963581

Select item 19635807.

p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS cell viability counter screen

Source:: Tox21

Assay data:214 Active, 153 Activity ≤ 1 µM, 9667 Tested

AID:: 1963580

Select item 19635798.

p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS cell viability counter screen

Source:: Tox21

Assay data:300 Active, 138 Activity ≤ 1 µM, 9667 Tested

AID:: 1963579

Select item 19635789.

p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:27 Active, 44 Activity ≤ 1 µM, 9667 Tested

AID:: 1963578

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 196357710.

p53 small molecule agonists, cell-based qHTS assay with human liver microsomes

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:43 Active, 55 Activity ≤ 1 µM, 9667 Tested

AID:: 1963577

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 192006811.

Human kisspeptin (KISS1R) small molecule agonists, calcium flux assay in KISS1R-HEK293 cells: Summary

Source:: Tox21

Protein Target:: KISS1 receptor [Homo sapiens]

Assay data:16 Active, 9667 Tested

AID:: 1920068

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Same Project

Select item 192006712.

Human gonadotropin-releasing hormone receptor (GnRHR) small molecule agonists, calcium flux assay in GnRHR-HEK293 cells: Summary

Source:: Tox21

Protein Target:: Gonadotropin-releasing hormone receptor [Homo sapiens]

Assay data:109 Active, 9667 Tested

AID:: 1920067

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Same Project

Select item 192006513.

G protein-coupled receptor (GPCR) small molecule agonists, calcium flux assay: HEK293 wild type cell line counter screen

Source:: Tox21

Assay data:47 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 9667 Tested

AID:: 1920065

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 192006414.

Human kisspeptin (KISS1R) small molecule agonists, calcium flux assay in KISS1R-HEK293 cells

Source:: Tox21

Protein Target:: KISS1 receptor [Homo sapiens]

Assay data:55 Active, 2 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 9667 Tested

AID:: 1920064

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 192006315.

Human gonadotropin-releasing hormone receptor (GnRHR) small molecule agonists, calcium flux assay in GnRHR-HEK293 cells

Source:: Tox21

Protein Target:: Gonadotropin-releasing hormone receptor [Homo sapiens]

Assay data:169 Active, 2 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 9667 Tested

AID:: 1920063

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 192006216.

High-throughput screening primary assay to identify small molecule activators of human guanylyl cyclase B (GC-B) receptor activity

Source:: Burnham Center for Chemical Genomics

Assay data:399 Active, 370620 Tested

AID:: 1920062

Summary Compounds, Active

Select item 191997017.

Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists, luciferase reporter gene qHTS assay in human keratinocytes: Summary

Source:: Tox21

Protein Target:: Nuclear factor (erythroid-derived 2)-like 2 [Homo sapiens]

Assay data:1038 Active, 9667 Tested

AID:: 1919970

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Same Project

Select item 191996918.

Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: luciferase reporter gene qHTS assay in human keratinocytes

Source:: Tox21

Protein Target:: Nuclear factor (erythroid-derived 2)-like 2 [Homo sapiens]

Assay data:1099 Active, 1 Activity ≤ 1 nM, 143 Activity ≤ 1 µM, 9667 Tested

AID:: 1919969

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 191996819.

Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: qHTS cell viability counter screen in human keratinocytes

Source:: Tox21

Assay data:683 Active, 47 Activity ≤ 1 µM, 9667 Tested

AID:: 1919968

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 191899020.

Increase the activity of the Burkholderia fixLJ 2-component system

Source:: ICCB-Longwood Screening Facility, Harvard Medical School

Protein Targets:: MULTISPECIES: oxygen response regulator transcription factor FixJ [Pseudomonadota]; ...
Total:: 2

Assay data:87 Active, 28704 Tested

AID:: 1918990

Summary Compounds, Active PubMed Citation

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Target

Proteins (524)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (829)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (92)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (318)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (47)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (362)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (415)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (599)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (8)
BioAssays extracted from the literature
NIH MLP (517)
BioAssays deposited by the NIH Molecular Libraries Program
Other (308)
BioAssays deposited by other experimentalists

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