BioAssays, Inactive for PubChem Compound (Select 73864) - PubChem BioAssay - NCBI

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Select item 19200681.

Human kisspeptin (KISS1R) small molecule agonists, calcium flux assay in KISS1R-HEK293 cells: Summary

Source:: Tox21

Protein Target:: KISS1 receptor [Homo sapiens]

Assay data:16 Active, 9667 Tested

AID:: 1920068

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19200672.

Human gonadotropin-releasing hormone receptor (GnRHR) small molecule agonists, calcium flux assay in GnRHR-HEK293 cells: Summary

Source:: Tox21

Protein Target:: Gonadotropin-releasing hormone receptor [Homo sapiens]

Assay data:109 Active, 9667 Tested

AID:: 1920067

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19200653.

G protein-coupled receptor (GPCR) small molecule agonists, calcium flux assay: HEK293 wild type cell line counter screen

Source:: Tox21

Assay data:47 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 9667 Tested

AID:: 1920065

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19200644.

Human kisspeptin (KISS1R) small molecule agonists, calcium flux assay in KISS1R-HEK293 cells

Source:: Tox21

Protein Target:: KISS1 receptor [Homo sapiens]

Assay data:55 Active, 2 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 9667 Tested

AID:: 1920064

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19200635.

Human gonadotropin-releasing hormone receptor (GnRHR) small molecule agonists, calcium flux assay in GnRHR-HEK293 cells

Source:: Tox21

Protein Target:: Gonadotropin-releasing hormone receptor [Homo sapiens]

Assay data:169 Active, 2 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 9667 Tested

AID:: 1920063

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19199696.

Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: luciferase reporter gene qHTS assay in human keratinocytes

Source:: Tox21

Protein Target:: Nuclear factor (erythroid-derived 2)-like 2 [Homo sapiens]

Assay data:1099 Active, 1 Activity ≤ 1 nM, 143 Activity ≤ 1 µM, 9667 Tested

AID:: 1919969

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19189697.

Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress

Source:: ICCB-Longwood Screening Facility, Harvard Medical School

Assay data:281 Active, 189401 Tested

AID:: 1918969

Summary Compounds, Active

Select item 16711998.

Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: luciferase reporter qHTS assay

Source:: Tox21

Protein Target:: cytochrome P450, family 1, subfamily A, polypeptide 2

Assay data:2934 Active, 132 Activity ≤ 1 µM, 9667 Tested

AID:: 1671199

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 16664719.

Agonist activity at ERbeta (unknown origin) expressed in human HeLa cells assessed as transcriptional activation measured after 24 hrs by luciferase reporter gene assay

Source:: ChEMBL

Protein Target:: Estrogen receptor beta

Assay data:3 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 7 Tested

AID:: 1666471

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 134739910.

Acetylcholinesterase (AChE) small molecule antagonists: enzyme-based qHTS assay with human liver microsomes

Source:: Tox21

Protein Target:: acetylcholinesterase

Assay data:127 Active, 16 Activity ≤ 1 µM, 9667 Tested

AID:: 1347399

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 134739811.

Acetylcholinesterase (AChE) small molecule antagonists: fluorescence cell-based qHTS assay

Source:: Tox21

Protein Target:: acetylcholinesterase

Assay data:388 Active, 111 Activity ≤ 1 µM, 9667 Tested

AID:: 1347398

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 134739712.

Acetylcholinesterase (AChE) small molecule antagonists: enzyme-based qHTS assay

Source:: Tox21

Protein Target:: acetylcholinesterase

Assay data:297 Active, 22 Activity ≤ 1 µM, 9667 Tested

AID:: 1347397

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 134739513.

Acetylcholinesterase (AChE) small molecule antagonists: colormetric cell-based qHTS assay

Source:: Tox21

Protein Target:: acetylcholinesterase

Assay data:445 Active, 57 Activity ≤ 1 µM, 9667 Tested

AID:: 1347395

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 134703714.

Caspase-3/7 induction in CHO-K1 cells by small molecules, qHTS assay: Summary

Source:: Tox21

Protein Targets:: Caspase-7; ...
Total:: 2

Assay data:221 Active, 9667 Tested

AID:: 1347037

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 134703615.

Progesterone receptor (PR) small molecule agonists, qHTS assay: Summary

Source:: Tox21

Protein Target:: progesterone receptor

Assay data:193 Active, 7 Activity ≤ 1 nM, 121 Activity ≤ 1 µM, 9667 Tested

AID:: 1347036

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 134703516.

TGF-beta/Smad small molecule agonists, qHTS assay: Summary

Source:: Tox21

Protein Targets:: SMAD family member 2; ...
Total:: 2

Assay data:8 Active, 2 Activity ≤ 1 µM, 9667 Tested

AID:: 1347035

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 134703417.

Caspase-3/7 induction in HepG2 cells by small molecules, qHTS assay: Summary

Source:: Tox21

Protein Targets:: caspase 7, apoptosis-related cysteine protease; ...
Total:: 2

Assay data:415 Active, 9667 Tested

AID:: 1347034

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 134698018.

Caspase-3/7 induction in CHO-K1 cells by small molecules, qHTS assay

Source:: Tox21

Protein Targets:: Caspase-7; ...
Total:: 2

Assay data:127 Active, 25 Activity ≤ 1 µM, 9667 Tested

AID:: 1346980

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 134697819.

Caspase-3/7 induction in HepG2 cells by small molecules, qHTS assay

Source:: Tox21

Protein Targets:: caspase 7, apoptosis-related cysteine protease; ...
Total:: 2

Assay data:262 Active, 1 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 9667 Tested

AID:: 1346978

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 134689120.

qHTS assay to identify small molecule agonists of the thyrotropin-releasing hormone receptor (TRHR) signaling pathway

Source:: Tox21

Protein Target:: thyrotropin-releasing hormone receptor

Assay data:85 Active, 5 Activity ≤ 1 µM, 9667 Tested

AID:: 1346891

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

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Target

Proteins (87)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (155)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (42)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (125)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (27)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (116)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (93)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (2)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (143)
BioAssays deposited by other experimentalists

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