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Extended Characterization of SMN2 Inhibitors: Righting Time Studies
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Extended Characterization of SMN2 Inhibitors: Body Weight Studies
Extended Characterization of SMN2 Inhibitors: Survival Studies
In vitro cytotoxicity was evaluated against melanoma SK-MEL-28 cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
In vitro cytotoxicity was evaluated againstCNS SNB-7 cells; 1 x 10E1
Tested for toxicity in mice
Assay data:7 Tested
SummaryPubMed Citation
Compound concentration in mole/kg/day lethal to 10% of mice
Assay data:771 Tested
In vitro cytotoxicity was evaluated against melanoma SK-MEL-28 cells; 4 x 10E1
Assay data:1 Tested
In vitro cytotoxicity was evaluated against melanoma SK-MEL-28 cells; 3 x 10E1
Assay data:2 Tested
In vitro cytotoxicity was evaluated against melanoma SK-MEL-28 cells; 2 x 10E1
In vitro cytotoxicity was evaluated against melanoma SK-MEL-28 cells; 1 x 10e1; 1 x 10E1
In vitro cytotoxicity was evaluated against melanoma SK-MEL-28 cells; 1 x 10E1
In vitro cytotoxicity was evaluated againstCNS SNB-7 cells; 3 x 10E1
In vitro cytotoxicity was evaluated againstCNS SNB-7 cells
Assay data:4 Tested
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
Assay data:10 Active, 8 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In vitro cytotoxicity was evaluated against lung NCI-H23 cells; 1 x 10E1
Oral dose required to inhibit PAF-induced mortality (PAF-Antagonistic activity)in mice by 50%.
SummaryPubMed CitationRelated BioAssays by Target
Assay data:62 Tested
Dose required to inhibit PAF-induced mortality by 50% in mice
Assay data:74 Tested
Antitumor activity against intraperitoneally implanted P388 murine leukemia in CD2F1 mice with 10E6 at 25 mg/kg on day 1, expressed tumor-free surv/total;0/5
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