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Antiviral activity against DENV-2 infected in African green monkey Vero cells assessed as reduction in virus-induced cytopathic effect measured after 15 to 30 mins by neutral red based analysis
Assay data:1 Active, 2 Tested
Summary
Antiviral activity against DENV-2 infected in African green monkey Vero cells assessed as reduction in virus-induced cytopathic effect measured after 15 to 30 mins by visual analysis
Assay data:2 Active, 2 Tested
Antiviral activity against DENV-2 infected in human Huh-7 cells assessed as reduction in virus-induced cytopathic effect measured after 15 to 30 mins by neutral red based analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
Antiviral activity against DENV-2 infected in human Huh-7 cells assessed as reduction in virus-induced cytopathic effect measured after 15 to 30 mins by visual analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of DENV2 N-terminally hexa-His tagged NS2B (48 to 95 residues) -NS3 (1 to 184 residues) protease expressed in Escherichia coli XL1 Blue using QXL570-Phe-Ala-Ser-Gly-Lys-Arg-Ser-Gln-Ile-Gly-Leu-Lys(5-TAMRA)-NH2 as substrate and measured for 15 mins by FRET assay
Assay data:4 Active, 9 Tested
Inhibition of DENV2 recombinant CF40-glycine fused NS2B-NS3 protease expressed in Escherichia coli SG13009 using Ac-TTSTRR-pNA as substrate preincubated for 50 mins followed by substrate addition by spectrophotometric assay
Assay data:4 Tested
Inhibition of DENV2 recombinant NS2B-NS3 protease expressed in Escherichia coli C41 using GRR-AMC as substrate incubated for 15 mins by Lineweaver-Burk plot analysis
Assay data:8 Tested
Inhibition of DENV2 N-terminally hexa-His tagged NS2B (49 to 92 residues) -NS3 (1 to 184 residues) protease using Ac-TTSTRR-pNA as substrate preincubated for 10 mins followed by substrate addition and measured after 120 mins by HTS assay
Assay data:1 Tested
Inhibition of DENV2 NS2B-NS3 protease using Boc-Gly-Lys-Arg-AMC as substrate incubated for 30 mins by fluorescence assay
Inhibition of DENV2 TSV01 NS2B-NS3 protease using BOC-GRR-AMC as substrate incubated for 30 mins by spectrofluorometeric assay
Assay data:5 Tested
Inhibition of DENV2 NS2B-G4-S-G4-NS3 protease using Bz-nKRR-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorescence microplate reader assay
Assay data:1 Active, 3 Tested
Antiviral activity against DENV2 New Guinea C infected in African green monkey Vero cells assessed as reduction in viral replication incubated for 72 hrs by light microscopic analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of DENV2 recombinant CF40gly(T)R fused NS2B-NS3 protease expressed in Escherichia coli XL1-Blue MRF using Boc-Gly-Arg-Arg-MCA as substrate incubated for 30 mins by fluorescence spectrophotometeric assay
Inhibition of DENV2 NS2B-NS3 protease using Bz-Nle-Lys-Arg-Arg-AMC as substrate preincubated for 15 mins followed by substrate addition by fluorescence assay
Inhibition of DENV2 hydrophilic domain of NS2B (48 aminoacids)-NS3 (185 aminoacids) protease using Bz-Nle-Lys-Arg-Arg-AMC as substrate preincubated for 15 mins followed by substrate addition by spectrofluorometeric assay
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of DENV2 recombinant NS2B-(G4-S-G4)-NS3 protease using Bz-nKRR-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by fluorescence spectrophotometric analysis
Assay data:2 Active, 3 Tested
Inhibition of DENV2 recombinant NS2B-NS3 protease expressed in Escherichia coli using Abz-RRRRSAG-nY-NH2 as substrate preincubated for 20 mins at 37 degC followed by substrate addition measured after 60 mins by fluorescence spectrophotometric analysis
Assay data:1 Active, 1 Tested
Inhibition of DENV2 recombinant NS2B-(G4-T-G4)-NS3 protease expressed in Escherichia coli XL1-Blue using Boc-Gly-Arg-Arg-AMC as substrate preincubated for 30 mins at 40 degC followed by substrate addition measured after 30 mins by fluorescence spectrophotometric analysis
Inhibition of DENV2 recombinant NS2B-(G4-T-G4)-NS3 protease expressed in Escherichia coli XL1-Blue using Boc-Gly-Arg-Arg-AMC as substrate preincubated for 30 mins at 37 degC followed by substrate addition measured after 30 mins by fluorescence spectrophotometric analysis
Inhibition of DENV2 recombinant NS2B-(G4-T-G4)-NS3 protease expressed in Escherichia coli XL1-Blue using Boc-Gly-Arg-Arg-AMC as substrate preincubated for 30 mins at 28 degC followed by substrate addition measured after 30 mins by fluorescence spectrophotometric analysis
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