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Inhibition of DENV4 N-terminally hexa-His tagged NS2B (48 to 95 residues) -NS3 (1 to 184 residues) protease expressed in Escherichia coli XL1 Blue using QXL570-Phe-Ala-Ser-Gly-Lys-Arg-Ser-Gln-Ile-Gly-Leu-Lys(5-TAMRA)-NH2 as substrate and measured for 15 mins by FRET assay
Assay data:9 Tested
SummaryPubMed Citation
Antiviral activity against DENV4 P11-08 infected in African green monkey Vero cells assessed as reduction in viral replication incubated for 72 hrs by light microscopic analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of DENV4 recombinant NS2B (1393 to 1441 residues)-NS3 (1475 to 1660 residues) protease expressed in Escherichia coli DH5alpha using AMC as substrate incubated for 20 mins by fluorescence spectroscopic assay
Assay data:1 Active, 7 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of DENV4 recombinant NS2B-NS3 protease expressed in Escherichia coli using Abz-RRRRSAG-nY-NH2 as substrate preincubated for 20 mins at 37 degC followed by substrate addition measured after 60 mins by fluorescence spectrophotometric analysis
Assay data:1 Tested
Inhibition of DENV4 NS2B-NS3 protease expressed in Escherichia coli BL21 (DE3) using Bz-Nle-Lys-Arg-Arg-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorescence plate reader analysis
Assay data:1 Active, 1 Tested
Antiviral activity against DENV4 infected in African green monkey Vero cells assessed as inhibition of viral infection by virucidal assay
Inhibition of Dengue virus 4 NS2B-NS3 protease using Benzoyl-Nle-Lys-Arg-Arg-AMC as substrate preincubated for 1 hrs followed by substrate addition and measured after 10 mins by fluorescence based plate reader analysis
Antiviral activity against DENV-4 RNA-dependent RNA polymerase infected in African green monkey Vero cells assessed as reduction in viral replication incubated for 2 days by qRT-PCR analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Antiviral activity against DENV-4 NS5 infected in African green monkey Vero cells
Antiviral activity against DENV-4 infected hamster BHK-21 cells assessed as reduction in viral replication incubated for 4 hrs
Inhibition of DENV-4 full length NS5/RNA-dependent RNA polymerase
Antiviral activity against DENV-4 infected in African green monkey Vero E6 cells
Inhibition of DENV-4 NS5
Assay data:1 Active, 3 Tested
Antiviral activity against DENV 4 infected in african green monkey Vero cells assessed as focus formation measured after 6 days
Antiviral activity against DENV 4
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Binding affinity to DENV-4 RNA-dependent RNA polymerase assessed as change in enthalpy by ITC analysis
Assay data:2 Tested
Antiviral activity against DENV4 (8124) infected in African green monkey Vero cells assessed as inhibition of virus induced cytopathic effect by crystal violet staining based plaque assay
Antiviral activity against DENV4 infected in hamster BHK-21 cells assessed as inhibition of virus induced cytopathic effect incubated for 45 mins by focus-formation assay
Antiviral activity against DENV4 infected in hamster BHK-21 cells assessed as inhibition of virus induced cytopathic effect by viral tox-glo assay
Inhibition of DENV4 (MY01-22713) RdRP expressed in Escherichia coli Rosetta2(DE3) incubated for 180 mins in presence of ATP,GTP,and UTP by scintillation counter analysis
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