Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of SARS-CoV-2 3CL-Pro proteolytic cleavage of a dual-labeled substrate by FRET at 1mM DTT.
Assay data:24 Active, 19 Activity ≤ 1 µM, 64 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of SARS-CoV-2 3CL-Pro proteolytic cleavage of a dual-labeled substrate by FRET.
Assay data:33 Active, 20 Activity ≤ 1 µM, 64 Tested
Inhibition of recombinant SARS-CoV-2 main protease using Dabcyl-KTSAVLQSGFRKM-E(Edans-NH2) as substrate preincubated for 15 mins followed by substrate addition by FRET analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant SARS-CoV-2 main protease expressed in Escherichia coli BL21 using Dabcyl-EDANS and Boc-Abu-Tle-Leu-Gln-AMC as substrate
Inhibition of SARS-CoV-2 RdRP using ATP substrate preincubated with compound for 30 mins followed by substrate addition and measured after 30 mins by Alphascreen microplate reader analysis
Assay data:2 Active, 2 Tested
Inhibition of MBP tagged recombinant SARS-CoV-2 main protease using DABCYL-KTSAVLeu(13C6,15N)-Q as substrate incubated for 2 to 3 hrs by mass spectrometric analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antiviral activity against SARS-CoV-2 NRC-03-nhCoV infected in african green monkey Vero E6 cells assessed as inhibition of virus-induced cytopathic effect measured after 72 hrs by crystal violet staining based assay
Assay data:1 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells pre-incubated for 1 hr followed by viral infection measured after 2 hrs by qRT-PCR analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of full length SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) using Dacyl-KTSAVLQSGFRKME-Edans fluorogenic peptide as substrate pre-incubated for 10 mins followed by substrate addition by FRET assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Antiviral activity against SARS-CoV-2 infected in HEK293T cells expressing ACE2/TMPRSS2 assessed as reduction in virus-induced cytopathic effect measured after 48 hrs by cellular ATP assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Binding affinity to SARS-CoV-2 Attenuator hairpin RNA by MST assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antiviral activity against SARS-COV2 infected in african green monkey Vero E6 cells assessed as inhibition of viral replication incubated for 48 hrs by plague assay
Antiviral activity against SARS-COV2 EPI_ISL_1172022 infected in african green monkey Vero E6 cells assessed as inhibition of viral replication incubated for 48 hrs by RT-qPCR analysis
Assay data:7 Tested
SummaryPubMed Citation
Inhibition of SARS-CoV-2 3CL protease by FRET assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of SARS-CoV-2 3CL protease assessed as inhibition constant
Assay data:4 Active, 3 Activity ≤ 1 µM, 7 Tested
Inhibition of SARS-CoV-2 3CL protease using DabcylKTSAVLQSGFRKME-Edans as substrate assessed as inhibition constant by fluorescence spectrophotometer analysis
Assay data:2 Tested
Inhibition of SARS-CoV-2 3CL protease using DabcylKTSAVLQSGFRKME-Edans amide as substrate assessed as inhibition constant
Assay data:5 Active, 2 Activity ≤ 1 µM, 5 Tested
Inhibition of SARS-CoV-2 3CL protease using NH2-SWTSAVLQSGFRKWA-COOH
Inhibition of SARS-CoV-2 3CL protease
Assay data:8 Active, 2 Activity ≤ 1 µM, 17 Tested
Inhibition of SARS-CoV-2 3CL protease Q189A mutant by FRET assay
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on