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Inhibition of recombinant Norovirus GII.4 C-terminal His6-tagged RNA-dependent RNA polymerase in Escherichia coli assessed as decrease in GTP incorporation incubated for 10 mins by scintillation counting method
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of Norovirus prototypic GII.4 3CL protease using HiLyte Fluor 488-labelled DFELQGPK as substrate incubated for 90 mins measured every mins for 20 mins by FRET assay
Assay data:6 Active, 3 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of norovirus GII.4 RNA-dependent RNA polymerase using poly(C)RNA as substrate incubated for 10 mins and measured after 15 mins by picogreen staining based assay
Assay data:3 Tested
SummaryPubMed Citation
Inhibition of Norovirus prototypic GII.4 3CL protease using HiLyte Fluor 488-labelled DFELQGPK as substrate incubated for 90 mins measured every mins for 20 mins by FRET assay relative to control
Assay data:1 Tested
Inhibition of recombinant human Norovirus GII.4 RNA-dependent RNA polymerase expressed in Escherichia coli assessed as inhibition of [3H]UTP incorporation using HCV 5'-untranslated region RNA template incubated for 2.5 hrs by radiometric assay
Assay data:1 Active, 1 Tested
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