PubChem BioAssay Links for Taxonomy (Select 63363) - PubChem BioAssay - NCBI

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Select item 18941301.

Binding affinity to Aquifex aeolicus LpxC assessed as inhibition constant at pH 5.5

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894130

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 17324042.

Inhibition of Aquifex aeolicus MraY using UDP-MurNAc-pentapeptide as substrate measured after 5 mins by UMP-Glo glycosyltransferase assay

Source:: ChEMBL

Protein Target:: Phospho-N-acetylmuramoyl-pentapeptide-transferase

Assay data:3 Tested

AID:: 1732404

Summary PubMed Citation Related BioAssays by Target

Select item 16035103.

Inhibition of MraY in Aquifex aeolicus

Source:: ChEMBL

Protein Target:: Phospho-N-acetylmuramoyl-pentapeptide-transferase

Assay data:19 Tested

AID:: 1603510

Summary PubMed Citation Related BioAssays by Target

Select item 14101014.

Inhibition of Aquifex aeolicus MraY expressed in Escherichia coli C41(DE3) using Park's nucleotide as substrate pretreated for 30 mins followed by substrate addition measured up to 2 mins by fluorescence assay

Source:: ChEMBL

Protein Target:: Phospho-N-acetylmuramoyl-pentapeptide-transferase

Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 4 Tested

AID:: 1410101

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 11637245.

Inhibition of Aquifex aeolicus IspH

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1163724

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 11637156.

Inhibition of Aquifex aeolicus IspE

Source:: ChEMBL

Assay data:3 Tested

AID:: 1163715

Summary PubMed Citation

Select item 11637267.

Inhibition of Aquifex aeolicus IspH assessed as residual activity at 1 mM

Source:: ChEMBL

Assay data:2 Tested

AID:: 1163726

Summary PubMed Citation

Select item 11195868.

Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21(DE3)

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1119586

Summary Compounds, Active

Select item 11195859.

Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21(DE3) using HMBPP as substrate preincubated for 10 mins followed by substrate addition

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1119585

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 109188210.

Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrate

Source:: ChEMBL

Protein Target:: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Assay data:4 Active, 1 Activity ≤ 1 µM, 21 Tested

AID:: 1091882

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 56832511.

Inhibition of Aquifex aeolicus LpxC

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 568325

Summary Compounds, Active PubMed Citation

Select item 32920912.

Binding affinity to Aquifex aeolicus sodium-coupled leucine transporter

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 329209

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 32920813.

Activity at Aquifex aeolicus sodium-coupled leucine transporter assessed as inhibition of L-[3H]Ala transport at 50 uM

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 329208

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 32920714.

Activity at Aquifex aeolicus sodium-coupled leucine transporter assessed as inhibition of L-[3H]Ala transport at 20 uM

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 329207

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 32920615.

Activity at Aquifex aeolicus sodium-coupled leucine transporter assessed as inhibition of L-[3H]Ala transport at 1 uM

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 329206

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 32920516.

Inhibition of L-[3H]Ala uptake at Aquifex aeolicus sodium-coupled leucine transporter

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 329205

Summary Compounds, Active PubMed Citation

Select item 32920417.

Inhibition of L-[3H]Leu uptake at Aquifex aeolicus sodium-coupled leucine transporter

Source:: ChEMBL

Assay data:2 Tested

AID:: 329204

Summary PubMed Citation

Select item 33033618.

Inhibition of Aquifex aeolicus LpxC

Source:: ChEMBL

Protein Target:: UDP-3-O-acyl-N-acetylglucosamine deacetylase

Assay data:1 Active, 1 Tested

AID:: 330336

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 28940219.

Displacement of [3H]leucine from Aquifex aeolicus His-LeuT expressed in Escherichia coli by scintillation proximity assay

Source:: ChEMBL

Assay data:4 Tested

AID:: 289402

Summary PubMed Citation

Select item 28772420.

Binding affinity to Aquifex aeolicus LpxC by isothermal titration calorimetry

Source:: ChEMBL

Protein Target:: UDP-3-O-acyl-N-acetylglucosamine deacetylase

Assay data:7 Active, 11 Tested

AID:: 287724

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (15)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (2)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (9)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (18)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (21)
BioAssays extracted from the literature

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