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Inhibition Assay from US Patent US8609622: "C-aryl glucoside derivatives, preparation process and pharmaceutical use thereof"
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of AHNAK in mouse C2C12 cells assessed as reduction in phospho-sites occupancy at 4 uM after 5 hrs by SILAC based LC-MS/MS analysis relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of recombinant mouse TREK2 expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clamp electrophysiological analysis
Assay data:1 Tested
Antagonist activity at mouse Cav3.1 expressed in HEK293T cells assessed as inhibition of current amplitude at holding potential of -100 mV by whole cell electrophysiological method
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at mouse Cav3.1 expressed in HEK293T cells assessed as increase in current amplitude at holding potential of -100 mV by whole cell electrophysiological method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Cav3.1 in mouse assessed as decrease in calcium flux preincubated for 3 mins followed by CaCl2 addition by Fluo-4-AM dye-based FLIPR assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cell membranes at 30 uM after 4 hrs by scintillation counting method
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA
Assay data:13 Active, 11 Activity ≤ 1 µM, 16 Tested
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay
Assay data:14 Active, 5 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 16 Tested
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs
Assay data:6 Active, 3 Activity ≤ 1 µM, 16 Tested
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR method
Assay data:18 Active, 1 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 18 Tested
Displacement of [3H]-1-MeHis-TRH from mouse TRH-R2 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting method
Assay data:1 Active, 1 Activity ≤ 1 µM, 18 Tested
Inhibition of mouse Sky kinase assessed as inhibition of src substrate phosphorylation by ELISA
Assay data:36 Active, 9 Activity ≤ 1 µM, 38 Tested
Inhibition of mouse SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillation counting
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization
Assay data:9 Tested
Inhibition of [3H]rolipram binding to Phosphodiesterase 4 (PDE IV)
Assay data:3 Active, 1 Activity ≤ 1 µM, 8 Tested
Displacement of [3H]-Rolipram from mouse brain homogenates
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Displacement of [3H]rolipram from mouse brain homogenates
Assay data:14 Active, 12 Activity ≤ 1 µM, 14 Tested
Inhibitory activity against histone deacetylases (HDAC) prepared from mouse melanoma B16/BL6 cells; Not tested
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
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