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Inhibition of recombinant Hepatitis A virus proteinase 3C using Ac-Leu-Ala-Ala-OH as a substrate expressed in Escherichia coli incubated for 15 mins by SDS-PAGE assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity against hepatitis A virus TICM005 infected in human Huh-7.5.1 cells assessed as reduction in cytoplasmic viral RNA level at 5 to 20 uM incubated for 72 hrs dosed after infection for 6 hrs by RT-qPCR method
Assay data:4 Tested
SummaryPubMed Citation
Antiviral activity against hepatitis A virus KRM031 infected in human Huh-7.5.1 cells assessed as reduction in cytoplasmic viral RNA level at 5 to 20 uM incubated for 72 hrs dosed after infection for 6 hrs by RT-qPCR method
Assay data:1 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against hepatitis A virus genotype 1b infected in human Huh-7.5.1 cells assessed as reduction in virus production incubated for 72 hrs by Nano-Glo luciferase assay
Assay data:4 Active, 4 Tested
Inhibition of HAV protease 3C expressed in Escherichia coli BL21(DE3) pLysS using Dabcyl-GLRTQSND (edans) G as substrate preincubated for 3 mins before enzyme addition by fluorescence method
Assay data:2 Active, 4 Tested
Binding affinity to Hepatitis A virus Protease 3C
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of HRV 3C using chromogenic peptide substrate pre-incubated for 15 mins before substrate addition and measured after 1 to 2 hrs by colorimetric method
Assay data:2 Active, 3 Tested
Inhibition of HAV 3C expressed in Escherichia coli BL21(DE3) pLysS using Dabcyl-GLRTQSND (edans) G as substrate preincubated for 3 mins before enzyme addition by fluorescence method based Cheng and Prusoff equation analysis
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of HAV 3C expressed in Escherichia coli BL21(DE3) pLysS using Dabcyl-GLRTQSND (edans) G as substrate preincubated for 3 mins before enzyme addition by fluorescence method
Activity of hepatitis A virus 3C proteinase assessed as compound hydrolysis by HPLC
Assay data:3 Active, 3 Activity ≤ 1 µM, 6 Tested
Inhibition of hepatitis A virus 3C proteinase by microplate assay
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of HAV protease 3C
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Hepatitis A virus His-tagged 3C-like proteinase by fluorometric assay
Assay data:4 Active, 1 Activity ≤ 1 µM, 8 Tested
Reversible inhibitory activity against Protease
Assay data:4 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antiviral activity against HAV HM175 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect measured after 48 hrs by crystal violet staining based assay
Assay data:18 Tested
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