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Inhibition of recombinant Hepatitis A virus proteinase 3C using Ac-Leu-Ala-Ala-OH as a substrate expressed in Escherichia coli incubated for 15 mins by SDS-PAGE assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity against Hepatitis A virus HM175 infected in monkey FRhK-4 cells assessed as reduction in viral growth incubated for 0.5 hrs followed by cell infection measured after 1 hr by crystal violet staining based assay relative to control
Assay data:3 Tested
SummaryPubMed Citation
Antiviral activity against hepatitis A virus TICM005 infected in human Huh-7.5.1 cells assessed as reduction in cytoplasmic viral RNA level at 5 to 20 uM incubated for 72 hrs dosed after infection for 6 hrs by RT-qPCR method
Assay data:4 Tested
Antiviral activity against hepatitis A virus KRM031 infected in human Huh-7.5.1 cells assessed as reduction in cytoplasmic viral RNA level at 5 to 20 uM incubated for 72 hrs dosed after infection for 6 hrs by RT-qPCR method
Assay data:1 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against hepatitis A virus infected in human Huh-7.5.1 cells assessed as reduction in viral RNA replication at 2 to 50 uM incubated for 72 hrs by luciferase reporter dependent subgenomic replicon assay
Antiviral activity against hepatitis A virus HM175 infected in human Huh-7.5.1 cells assessed as reduction in HAV2c Protein expression at 10 uM incubated for 48 hrs by immunofluorescence assay
Assay data:4 Active, 4 Tested
Antiviral activity against hepatitis A virus genotype 1b infected in human Huh-7.5.1 cells assessed as reduction in virus production at 10 uM incubated for 72 hrs after 6 hrs HAV/NLuc infection by Nano-Glo luciferase assay
Antiviral activity against hepatitis A virus genotype 1b infected in human Huh-7.5.1 cells assessed as reduction in virus production at 10 uM incubated for 6 hrs with simultaneous HAV/NLuc infection by Nano-Glo luciferase assay
Antiviral activity against hepatitis A virus genotype 1b infected in human Huh-7.5.1 cells assessed as reduction in virus production at 10 uM incubated for 24 hrs and then cells were harvested followed by HAV/NLuc infection by Nano-Glo luciferase assay
Antiviral activity against hepatitis A virus HM175/18f infected in human Huh-7.5.1 cells assessed as reduction in HM175 production at 2 to 50 uM incubated for 72 hrs by RT-qPCR method
Antiviral activity against hepatitis A virus genotype 1b infected in human Huh-7.5.1 cells assessed as reduction in virus production incubated for 72 hrs by Nano-Glo luciferase assay
Antiviral activity against hepatitis A virus genotype 1b infected in human Huh-7.5.1 cells assessed as reduction in virus production at 10 uM incubated for 72 hrs by Nano-Glo luciferase assay
Assay data:8 Active, 42 Tested
Inhibition of HAV protease 3C expressed in Escherichia coli BL21(DE3) pLysS at 0.1 uM using Dabcyl-GLRTQSND (edans) G as substrate preincubated for 3 mins before enzyme addition by fluorescence method relative to control
Inhibition of HAV protease 3C expressed in Escherichia coli BL21(DE3) pLysS at 1 uM using Dabcyl-GLRTQSND (edans) G as substrate preincubated for 3 mins before enzyme addition by fluorescence method relative to control
Inhibition of HAV protease 3C expressed in Escherichia coli BL21(DE3) pLysS at 10 uM using Dabcyl-GLRTQSND (edans) G as substrate preincubated for 3 mins before enzyme addition by fluorescence method relative to control
Inhibition of HAV protease 3C expressed in Escherichia coli BL21(DE3) pLysS at 100 uM using Dabcyl-GLRTQSND (edans) G as substrate preincubated for 3 mins before enzyme addition by fluorescence method relative to control
Inhibition of HAV protease 3C expressed in Escherichia coli BL21(DE3) pLysS using Dabcyl-GLRTQSND (edans) G as substrate preincubated for 3 mins before enzyme addition by fluorescence method
Assay data:2 Active, 4 Tested
Binding affinity to Hepatitis A virus Protease 3C
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of HRV 3C using chromogenic peptide substrate pre-incubated for 15 mins before substrate addition and measured after 1 to 2 hrs by colorimetric method
Assay data:2 Active, 3 Tested
Inhibition of HAV 3C expressed in Escherichia coli BL21(DE3) pLysS using Dabcyl-GLRTQSND (edans) G as substrate preincubated for 3 mins before enzyme addition by fluorescence method based Cheng and Prusoff equation analysis
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
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