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Re-testing in dose-response curve in Dd2 pLDH assay, at 72h
Assay data:15 Active, 4 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Re-testing in dose-response curve in 3D7 pLDH assay, at 72h
Assay data:74 Active, 47 Activity ≤ 1 µM, 84 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Hit confirmation in dose-response curve in NF54 nanoGlo assay, at 12h
Assay data:415 Active, 46 Activity ≤ 1 µM, 647 Tested
Hit confirmation in dose-response curve in Dd2 pLDH assay, at 72h
Assay data:532 Active, 72 Activity ≤ 1 µM, 647 Tested
Hit confirmation in dose-response curve in NF54 pLDH assay, at 72h
Assay data:548 Active, 70 Activity ≤ 1 µM, 647 Tested
Hit confirmation in dose-response curve in NF54 nanoGlo assay, at 72h
Assay data:633 Active, 123 Activity ≤ 1 µM, 647 Tested
In vitro enzyme assay to detect hydrolysis of chlorophenol red-beta-D-galactopyranosidase directly proportional to the number of Toxoplasma stably expressing beta-galactosidase
Assay data:102 Active, 8 Activity ≤ 1 µM, 84955 Tested
Potentiation of chloroquine-induced anitiparasitic activity in chloroquine-resistant/verapamil-sensitive Plasmodium falciparum Dd2 assessed as chloroquine IC50 (Rvb = 150 nM)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antiparasitic activity against chloroquine-resistant/verapamil-sensitive Plasmodium falciparum VS/1
Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum HB3
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 4 Tested
Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum 3D7
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Antiparasitic activity against chloroquine-resistant/verapamil-sensitive Plasmodium falciparum FCR-3/Gambia
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Antiparasitic activity against chloroquine-resistant/verapamil-sensitive Plasmodium falciparum Dd2
Antiparasitic activity against chloroquine-resistant/verapamil-insensitive Plasmodium falciparum 7G8
OSM: Inhibition of Plasmodium falciparum K1 growth. IC50 values determined from 21 point dose response curves. Avery Group Griffith.
Assay data:6 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 9 Tested
OSM: CSIR assay K1: Compounds were tested for inhibition of Plasmodium falciparum growth using a SYBR green I fluorescence based assay.
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells
Assay data:37 Active, 3 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 37 Tested
NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay
Assay data:4616 Active, 9 Activity ≤ 1 nM, 3714 Activity ≤ 1 µM, 5614 Tested
NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay
Assay data:4209 Active, 3 Activity ≤ 1 nM, 3165 Activity ≤ 1 µM, 5614 Tested
Antimalarial activity: Gametocytes Plasmodium falciparum NF54 Gametocytes Stage V: inhibition at 10 uM (%)
Assay data:33 Active, 7 Activity ≤ 1 µM, 116 Tested
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