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P. falciparum growth and inhibition assays from US Patent US11903936: "Anti-malarial agents"
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
DHODH Kinetic Analysis from US Patent US11903936: "Anti-malarial agents"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
Re-testing in dose-response curve in Dd2 pLDH assay, at 72h
Assay data:15 Active, 4 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antimalarial activity against plasmodium falciparum 3D7 assessed as bacterial growth inhibition
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Antimalarial activity against chloroquine sensitive Plasmodium falciparum FCR-3 infected in mouse FM3A cells ssessed as reduction in parasite growth
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antiplasmodial activity against Plasmodium falciparum assessed as reduction in parasite growth
Antiplasmodial activity against multidrug resistant Plasmodium falciparum Dd2 assessed as reduction in parasite growth
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as inhibition of parasite proliferation in thiamine free medium by SYBR-Safe assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 9 Tested
Antiparasitic activity against Cryptosporidium parvum assessed as reduction in parasitic growth
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Antiplasmodial activity against Plasmodium falciparum W2 infected in red blood cells (unknown origin) incubated for 72 hrs by LDH assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 5 Tested
Antimalarial activity against Plasmodium falciparum NF54 assessed as inhibition of cell growth incubated for 72 hrs by SYBR Green I staining based fluorescence analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Antimalarial activity against Plasmodium falciparum W2 assessed as reduction in malarial growth
In vivo antimalarial activity against Plasmodium berghei infected mouse model assessed as parasitemia at 8 mg/kg, po in presence of Mefloquine hydrochloride
Assay data:1 Active, 2 Activity ≤ 1 µM, 2 Tested
Antimalarial activity against Plasmodium falciparum 3D7 assessed as reduction in malarial growth cells
Antimalarial activity against Plasmodium falciparum NF54 assessed as reduction in cell growth
Assay data:17 Active, 4 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Antiplasmodial activity against Plasmodium falciparum NF54 assessed as reduction in malarial growth
Antimalarial activity against Plasmodium falciparum K1 assessed as inhibition of malarial growth
Assay data:11 Active, 3 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
Antimalarial activity against Plasmodium falciparum HB3 assessed as inhibition of malarial growth
Assay data:7 Active, 2 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Antimalarial activity against Plasmodium falciparum 3D7 assessed as inhibition of malarial growth
Antimalarial activity against Plasmodium falciparum NF54 assessed as inhibition of malarial growth
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