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Inhibition constant for YOP protein tyrosine phosphatase at pH 6.6
Assay data:10 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Yersinia pestis outer protein H expressed in Escherichia coli after 15 to 20 mins
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Yersinia pestis YOpH
Assay data:17 Active, 15 Activity ≤ 1 µM, 17 Tested
Inhibition of His6-tagged Yersinia pestis YbtE-mediated [3H]salicyl-ypArCP-H6 formation after 1.5 hrs by microplate counting
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Competitive inhibition of Yersinia pestis YbtE in presence of increasing concentration of ATP
Inhibition of adenylation activity of Yersinia pestis YbtE after 15 mins by ATP-[32P]pyrophosphate exchange assay
Inhibition of Yersinia pestis YopH after 15 mins by pNPP hydrolysis assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Yersinia pestis YbtE assessed as incorporation of [3H]salicyl group to HMWP2 protein
Assay data:29 Active, 25 Activity ≤ 1 µM, 33 Tested
Inhibitory concentration against Yersinia pestis YopH expressed in Escherichia coli BL21 cells
Assay data:7 Active, 16 Tested
Inhibition of Tyrosine phosphatase from Yersinia pestis expressed in Escherichia coli BL21 (DE3) cells
Assay data:5 Active, 17 Tested
Inhibition of Yersinia pestis outer protein H expressed in Escherichia coli after 15 to 20 mins in absence of 0.01% TX-100
Inhibition of Yersinia pestis outer protein H expressed in Escherichia coli after 15 to 20 mins in presence of 0.01% TX-100
Inhibition of His6-tagged Yersinia pestis YbtE-mediated [3H]salicyl-ypArCP-H6 formation up to 400 uM after 1.5 hrs by microplate counting
Assay data:1 Tested
Ratio of IC50 for drug to 5'-O-[N-(salicyl)-sulfomyl]-adenosine for Yersinia pestis YbtE assessed as incorporation of [3H]salicyl group to HMWP2 protein
Assay data:32 Tested
Inhibition of Yersinia pestis PTPase domain of outer protein H expressed in Escherichia coli assessed as hydrolysis of substrate monitored at 30 sec intervals over 15 mins by Michaelis-Menten constants analysis
Assay data:12 Tested
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibitors of Y. pestis Topo-I using cleavage product accumulation Measured in Biochemical System Using Plate Reader - 2123-01_Inhibitor_Dose_CherryPick_Activity
Assay data:44 Active, 151 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibitors of Y. pestis Topo-I using cleavage product accumulation Measured in Biochemical System Using Plate Reader - 2123-01_Inhibitor_SinglePoint_HTS_Activity
Assay data:229 Active, 356500 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
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