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Steady-State Kinetics from Article 10.1021/acs.biochem.5b01301: "Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase."
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Inhibition Kinetics from Article 10.1021/acs.biochem.5b01301: "Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase."
Assay data:20 Active, 9 Activity ≤ 1 µM, 22 Tested
Antibacterial activity against Yersinia pestis CO92 assessed as inhibition of bacterial growth
Assay data:3 Tested
SummaryPubMed Citation
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6988 model assessed as bacterial burden in blood at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.2 10'7CFU/ml)
Assay data:1 Tested
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6889 model assessed as bacterial burden in blood at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.2 10'7CFU/ml)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6783 model assessed as bacterial burden in blood at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.2 10'7CFU/ml)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2083 model assessed as bacterial burden in blood at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.2 10'7CFU/ml)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6127 model assessed as bacterial burden in blood at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 1.2 10'7CFU/ml)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6872 model assessed as bacterial burden in blood at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.2 10'7CFU/ml)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6106 model assessed as bacterial burden in blood at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.2 10'7CFU/ml)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6873 model assessed as bacterial burden in blood at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.2 10'7CFU/ml)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6436 model assessed as bacterial burden in blood at 25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.2 10'7CFU/ml)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey 8047 model assessed as bacterial burden in brain at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 10 days (Rvb = 1.9 10'6CFU/g)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6988 model assessed as bacterial burden in brain at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.9 10'6CFU/g)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6960 model assessed as bacterial burden in brain at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.9 10'6CFU/g)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6889 model assessed as bacterial burden in brain at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.9 10'6CFU/g)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey C2149 model assessed as bacterial burden in brain at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.9 10'6CFU/g)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6861 model assessed as bacterial burden in brain at 6.25 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.9 10'6CFU/g)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6783 model assessed as bacterial burden in brain at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.9 10'6CFU/g)
Antibacterial activity against Yersinia pestis Colorado 92 infected in African green monkey B6672 model assessed as bacterial burden in brain at 12.5 mg/kg, iv administered within 6 hrs post onset of sustained fever as 30 mins infusion for 5 days (Rvb = 1.9 10'6CFU/g)
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