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Antiviral activity against Influenza A virus (A/California/07/09(H1N1)) infected in MDCK cells assessed as inhibition of viral replication after 48 hrs by hemagglutination test
Assay data:4 Active, 16 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against rimantidine, amantidine-resistant Influenza A virus (A/California/07/09(H1N1)) pdm09 infected in MDCK cells assessed as inhibition of viral replication after 1 hrs by hemagglutination assay
Assay data:19 Active, 57 Tested
Antiviral activity against rimantidine, amantadine-resistant Influenza A virus (A/California/07/09(H1N1)) pdm09 infected in MDCK cells assessed as inhibition of viral replication by hemagglutinin titer assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity against Influenza virus A/California/07/09 (H1N1) pdm09 infected in MDCK cells after 48 hrs followed by incubated in chicken erythrocytes for 1 hr by hemagglutinination based end-point dilution method
Assay data:7 Active, 28 Tested
Inhibition of Influenza A virus (A/California/07/2009 (H1N1)) neuraminidase N1 H275Y mutant using MUNANA as substrate preincubated for 30 mins followed by substrate addition by fluorescence method
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of Influenza A virus (A/California/07/2009(H1N1)) neuraminidase by DNA-linked inhibitor antibody assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of biotinylated 5-(4-((Z)-3-Carboxy-3-hydroxyacryloyl)-4-(4-chlorobenzyl)piperidine-1-carbonyl)-2-((13,35-dioxo-39-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazole-4-yl)-3,6,9,16,19,22,25,28,31-nonaoxa-12,34-diazanonatriacontyl)oxy)benzoic acid binding to Influenza A virus (A/California/07/2009(H1N1)) N-terminal GST-tagged polymerase acidic subunit N-terminal domain expressed in Escherichia coli BL21 (DE3) RIL cells measured after 120 mins by Alphascreen assay
Assay data:25 Active, 14 Activity ≤ 1 µM, 58 Tested
Antiviral activity against Influenza A virus (A/California/07/09(H1N1))pdm09 infected in MDCK cells assessed as reduction in viral replication preincubated with compound for 1 hr followed by viral infection and measured after viral cultivation for 48 hrs by hemagglutination test
Assay data:4 Active, 1 Activity ≤ 1 µM, 11 Tested
Inhibition of Influenza A virus (A/California/07/2009(H1N1)) Neuraminidase N1 at pH 6.15 using 4-MUNANA substrate incubated for 20 mins by fluorometric assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of Influenza A virus (A/California/07/2009(H1N1)) Neuraminidase N1 at pH 7.4 by DIANA assay
Assay data:9 Active, 3 Activity ≤ 1 µM, 22 Tested
Inhibition of Influenza A virus (A/California/07/09 (H1N1)) neuraminidase activity using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 6 Tested
Inhibition of Influenza A virus (A/California/07/09 (H1N1)) neuraminidase activity using 4-MUNANA as substrate measured every min for 60 mins by fluorescence assay
Antiviral activity against oseltamivir/amantadine-resistant Influenza A virus (A/California/07/2009(H1N1)) infected in MDCK cells expressing ST6Gal-1 assessed as reduction in plaque formation after 2 days by crystal violet staining based assay
Assay data:16 Active, 12 Activity ≤ 1 µM, 17 Tested
Antiviral activity against Influenza A virus (A/California/07/09(H1N1)) pdm09 infected in MDCK cells pretreated for 1 hr followed by viral infection incubated for 24 hrs measured after 48 hrs by hemagglutination test
Antiviral activity against Influenza A virus A/California/07/2009(H1N1) infected in MDCK cells expressing ST6Gal 1 preincubated with virus and cells for 30 mins followed viral infection measured after 2 to 3 days by naphthalene black dye-based plaque reduction assay
Assay data:1 Active, 1 Tested
Antiviral activity against amantadine-resistant Influenza A virus A/California/07/2009 (H1N1) expressing M2 proton channel S31N mutant infected in MDCK cells harboring ST6Gal1 gene assessed as reduction in plaque formation measured after 2 days post infection by crystal violet staining based
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Antiviral activity against Influenza A virus (A/California/07/09(H1N1))pdm09 infected in MDCK cells assessed as decrease in virus production preincubated for 1 hr with cells followed by viral infection measured after 24 hrs by hemagglutination assay
Assay data:7 Active, 1 Activity ≤ 1 µM, 22 Tested
Antiviral activity against Influenza A virus (A/California/07/09(H1N1)) pdm09 infected in chicken erythrocytes incubated for 1 hr with supernatants from 1 hr compound pre-treated MDCK cells infected with Influenza A virus (A/California/07/2009(H1N1)) pdm09 for 48 hrs assessed as reduction in viral replication by hemagglutination assay
Assay data:1 Active, 23 Tested
Inhibition of Influenza A virus (A/California/07/2009(H1N1)) recombinant wild type N-terminal FLAG-tagged neuraminidase ectodomain (82 to 469 residues) transfected in Drosophila Schneider S2 cells using 4-MUNANA as substrate after 20 mins by fluorometric method
Antiviral activity against Influenza A virus (A/California/07/2009(H1N1)) infected in MDCK cells
Assay data:4 Active, 35 Tested
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