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Total plasma concentration in human CGRPalpha-induced migraine marmoset model at 3 mg/kg, sc measured after 15 to 105 mins
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Total plasma concentration in human CGRPalpha-induced migraine marmoset model at 7 mg/kg, sc measured after 15 to 105 mins
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 10 mg.Kg-1 level studied on day 1 in female Callithrix jacchus
Assay data:1 Active, 1 Tested
SummaryCompounds, Active
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 10 mg.Kg-1 level studied on day 1 in male Callithrix jacchus
Plasma concentration in marmoset at 0.03 mg/kg, sc measured 15 to 105 mins post-dose
Plasma concentration in marmoset at 0.03 g/kg, sc after 15 mins
Plasma concentration in marmoset at 0.03 g/kg, sc after 105 mins
Plasma concentration in marmoset at 0.03 g/kg, sc after 60 mins
Plasma concentration in Harlan marmoset at 7 mg/kg, sc at 15 mins
Plasma concentration in Harlan marmoset at 7 mg/kg, sc after 60 to 105 mins
Cmax in marmoset at 3 mg/kg, po
SummaryCompounds, ActivePubMed Citation
Agonist activity at marmoset beta3-adrenergic receptor
Cmax (0-168h) of total radioactivity following single oral administration of [14C] aliskiren hemifumarate at 3 mg.Kg-1 level in marmoset
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Cmax (0-168h) of unlabeled aliskiren hemifumarate following single oral administration of aliskiren hemifumarate at 3 mg.Kg-1 level in marmoset
Displacement of [3H]GR205171 from marmoset cerebral striatum NK1 receptor after 60 mins by scintillation counting analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of marmoset placenta 17beta-HSD1 cytosolic fraction using unlabelled and [2,4,6,7-3H]estrone as substrate after 10 mins by HPLC analysis in presence of NADH
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]-GR125743 from 5HT1B receptor in marmoset brain cortex after 45 mins by liquid scintillation spectrometry
Displacement of [3H]-WAY100635 from 5HT1A receptor in marmoset brain cortex after 45 mins by liquid scintillation spectrometry
Displacement of [I125]CGRP from marmoset CGRP receptor
Inhibition of renin in marmoset plasma
Assay data:33 Active, 3 Activity ≤ 1 nM, 33 Activity ≤ 1 µM, 34 Tested
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