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Select item 77491961.

The Longevity-Associated SH2B3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects

Chia-Ling Kuo, Micaella Joaquim, George A Kuchel, Luigi Ferrucci, Lorna W Harries, Luke C Pilling, David Melzer

J Gerontol A Biol Sci Med Sci. 2020 Sep; 75(9): 1656–1662. Published online 2019 Aug 20. doi: 10.1093/gerona/glz191

Correction in:: J Gerontol A Biol Sci Med Sci. 2020 Sep; 75(9): 1686.

PMCID:: PMC7749196

Abstract Article PDF–452K

Select item 67560242.

SH2B3 inactivation through CN-LOH 12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain

Paul B. Sinclair, Sarra Ryan, Matthew Bashton, Shaun Hollern, Rebecca Hanna, Marian Case, Edward C. Schwalbe, Claire J. Schwab, Ruth E. Cranston, Brian D. Young, Julie A. E. Irving, Ajay J. Vora, Anthony V. Moorman, Christine J. Harrison

Leukemia. 2019; 33(8): 1881–1894. Published online 2019 Feb 28. doi: 10.1038/s41375-019-0412-1

PMCID:: PMC6756024

Abstract Article PDF–2.8M

Select item 62831443.

Role of SH2B3 R262W gene polymorphism and risk of coronary heart disease: A PRISMA-compliant meta-analysis

Lu Hong, Yu-Feng Jiang, Min Chen, Nan-Nan Zhang, Hua-Jia Yang, Qing Rui, Ya-Feng Zhou

Medicine (Baltimore) 2018 Nov; 97(48): e13436. Published online 2018 Nov 30. doi: 10.1097/MD.0000000000013436

PMCID:: PMC6283144

Abstract Article PDF–1.0M

Select item 50455004.

Overexpression of Lnk in the Ovaries Is Involved in Insulin Resistance in Women With Polycystic Ovary Syndrome

Meihua Hao, Feng Yuan, Chenchen Jin, Zehong Zhou, Qi Cao, Ling Xu, Guanlei Wang, Hui Huang, Dongzi Yang, Meiqing Xie, Xiaomiao Zhao

Endocrinology. 2016 Oct; 157(10): 3709–3718. Published online 2016 Jul 26. doi: 10.1210/en.2016-1234

PMCID:: PMC5045500

Abstract Article

Select item 47639805.

Linking Inflammation and Hypertension via LNK/SH2B3

Bethany L. Dale, Meena S. Madhur

Curr Opin Nephrol Hypertens. Author manuscript; available in PMC 2017 Mar 1.

Published in final edited form as: Curr Opin Nephrol Hypertens. 2016 Mar; 25(2): 87–93. doi: 10.1097/MNH.0000000000000196

PMCID:: PMC4763980

Abstract Article PDF–636K

Select item 46973476.

Mutational Analysis of SH2B3 in Korean Patients With BCR-ABL1 Negative Myeloproliferative Neoplasm

Namhee Kim, In-Suk Kim, Chulhun Ludgerus Chang, Eun Yup Lee, Hyung Hoi Kim, Moo-Kon Song, Ho-Jin Shin, Joo Seop Chung

Ann Lab Med. 2016 Jan; 36(1): 67–69. Published online 2015 Oct 26. doi: 10.3343/alm.2016.36.1.67

PMCID:: PMC4697347

Article PDF–561K

Select item 46751007.

Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer

Rayjean J. Hung, Cornelia M. Ulrich, Ellen L. Goode, Yonathan Brhane, Kenneth Muir, Andrew T. Chan, Loic Le Marchand, Joellen Schildkraut, John S. Witte, Rosalind Eeles, Paolo Boffetta, Margaret R. Spitz, Julia G. Poirier, David N. Rider, Brooke L. Fridley, Zhihua Chen, Christopher Haiman, Fredrick Schumacher, Douglas F. Easton, Maria Teresa Landi, Paul Brennan, Richard Houlston, David C. Christiani, John K. Field, Heike Bickeböller, Angela Risch, Zsofia Kote-Jarai, Fredrik Wiklund, Henrik Grönberg, Stephen Chanock, Sonja I. Berndt, Peter Kraft, Sara Lindström, Ali Amin Al Olama, Honglin Song, Catherine Phelan, Nicholas Wentzensen, Ulrike Peters, Martha L. Slattery, for GECCO, Thomas A. Sellers, for FOCI, Graham Casey, Stephen B. Gruber, for CORECT, David J. Hunter, for DRIVE, Christopher I. Amos, Brian Henderson, on behalf of the GAME-ON Network

J Natl Cancer Inst. 2015 Nov; 107(11): djv246. Published online 2015 Aug 29. doi: 10.1093/jnci/djv246

PMCID:: PMC4675100

Abstract Article PDF–7.0M

Select item 41888048.

LNK (SH2B3): paradoxical effects in ovarian cancer

Ling-Wen Ding, Qiao-Yang Sun, De-Chen Lin, Wenwen Chien, Norimichi Hattori, Xue-Ming Dong, Sigal Gery, Manoj Garg, Ngan B. Doan, Jonathan W. Said, Jin-Fen Xiao, Henry Yang, Li-Zhen Liu, Xuan Meng, Ruby Yun-Ju Huang, Kai Tang, H Phillip Koeffler

Oncogene. Author manuscript; available in PMC 2015 Sep 12.

Published in final edited form as: Oncogene. 2015 Mar 12; 34(11): 1463–1474. Published online 2014 Apr 7. doi: 10.1038/onc.2014.34

PMCID:: PMC4188804

Abstract Article PDF–2.1M

Select item 37621089.

Infrequent occurrence of mutations in the PH domain of LNK in patients with JAK2 mutation-negative ‘idiopathic’ erythrocytosis

Ambra Spolverini, Lisa Pieri, Paola Guglielmelli, Alessandro Pancrazzi, Tiziana Fanelli, Chiara Paoli, Alberto Bosi, Ilaria Nichele, Marco Ruggeri, Alessandro M. Vannucchi

Haematologica. 2013 Sep; 98(9): e101–e102. doi: 10.3324/haematol.2013.090175

PMCID:: PMC3762108

Article PDF–151K

Select item 367457910.

A nonsynonymous LNK polymorphism associated with idiopathic erythrocytosis

Mary Frances McMullin, Chao Wu, Melanie J Percy, Wei Tong

Am J Hematol. Author manuscript; available in PMC 2013 Jun 6.

Published in final edited form as: Am J Hematol. 2011 Nov; 86(11): 962–964. Published online 2011 Aug 22. doi: 10.1002/ajh.22154

PMCID:: PMC3674579

Abstract Article PDF–489K

Select item 303206011.

Evolutionary and Functional Analysis of Celiac Risk Loci Reveals SH2B3 as a Protective Factor against Bacterial Infection

Alexandra Zhernakova, Clara C. Elbers, Bart Ferwerda, Jihane Romanos, Gosia Trynka, Patrick C. Dubois, Carolien G.F. de Kovel, Lude Franke, Marije Oosting, Donatella Barisani, Maria Teresa Bardella, Finnish Celiac Disease Study Group, Leo A.B. Joosten, Paivi Saavalainen, David A. van Heel, Carlo Catassi, Mihai G. Netea, Cisca Wijmenga

Am J Hum Genet. 2010 Jun 11; 86(6): 970–977. doi: 10.1016/j.ajhg.2010.05.004

PMCID:: PMC3032060

Abstract Article PDF–511K

Select item 1114377212.

Negative regulation of SH2B3 by SMYD5 controls epithelial-mesenchymal transition in lung cancer

In Hwan Tae, Tae Young Ryu, Yunsang Kang, Jinkwon Lee, Kwanho Kim, Jeong Min Lee, Hee-Won Kim, Jung Heon Ko, Dae-Soo Kim, Mi-Young Son, Hyun-Soo Cho

Mol Cells. 2024 May; 47(5): 100067. Published online 2024 May 7. doi: 10.1016/j.mocell.2024.100067

PMCID:: PMC11143772

Abstract Article PDF–6.3M

Select item 861297213.

The autoimmune risk R262W variant of the adaptor SH2B3 improves survival in sepsis

Eric J. Allenspach, Nicholas J. Shubin, Karen Cerosaletti, Carmen Mikacenic, Jacquelyn A Gorman, Matthew A. MacQuivey, Aaron B.I. Rosen, Andrew E. Timms, Michelle N. Wray-Dutra, Kerri Niino, Denny Liggitt, Mark M. Wurfel, Jane H. Buckner, Adrian M. Piliponsky, David J. Rawlings

J Immunol. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: J Immunol. 2021 Dec 1; 207(11): 2710–2719. Published online 2021 Nov 5. doi: 10.4049/jimmunol.2100454

PMCID:: PMC8612972

Abstract Article PDF–2.5M

Select item 790617314.

LNK promotes granulosa cell apoptosis in PCOS via negatively regulating insulin-stimulated AKT-FOXO3 pathway

Min Tan, Yanxiang Cheng, Xiaozhu Zhong, Dongyong Yang, Sushi Jiang, Yang Ye, Miao Ding, Guijun Guan, Dongzi Yang, Xiaomiao Zhao

Aging (Albany NY) 2021 Feb 15; 13(3): 4617–4633. Published online 2021 Jan 20. doi: 10.18632/aging.202421

PMCID:: PMC7906173

Abstract Article PDF–1.2M

Select item 662035515.

Combined Analysis of Methylation and Gene Expression Profiles in Separate Compartments of Small Bowel Mucosa Identified Celiac Disease Patients’ Signatures

D. Cielo, M. Galatola, N. Fernandez-Jimenez, L. De Leo, K. Garcia-Etxebarria, C. Loganes, A. Tommasini, T. Not, R. Auricchio, L. Greco, J. R. Bilbao

Sci Rep. 2019; 9: 10020. Published online 2019 Jul 10. doi: 10.1038/s41598-019-46468-2

PMCID:: PMC6620355

Abstract Article PDF–2.1M

Select item 652756516.

LNK suppresses interferon signaling in melanoma

Ling-Wen Ding, Qiao-Yang Sun, Jarem J. Edwards, Lucia Torres Fernández, Xue-Bin Ran, Si-Qin Zhou, Richard A. Scolyer, James S. Wilmott, John F. Thompson, Ngan Doan, Jonathan W. Said, Nachiyappan Venkatachalam, Jin-Fen Xiao, Xin-Yi Loh, Maren Pein, Liang Xu, David W. Mullins, Henry Yang, De-Chen Lin, H. Phillip Koeffler

Nat Commun. 2019; 10: 2230. Published online 2019 May 20. doi: 10.1038/s41467-019-09711-y

PMCID:: PMC6527565

Abstract Article PDF–2.9M

Select item 633465917.

Evidence for a Causal Role of the SH2B3-β₂M Axis in Blood Pressure Regulation: the Framingham Heart Study

Joshua A. KEEFE, Shih-Jen HWANG, Tianxiao HUAN, Michael MENDELSON, Chen YAO, Paul COURCHESNE, Mohamed A. SALEH, Meena S. MADHUR, Daniel LEVY

Hypertension. Author manuscript; available in PMC 2020 Feb 1.

Published in final edited form as: Hypertension. 2019 Feb; 73(2): 497–503. doi: 10.1161/HYPERTENSIONAHA.118.12094

PMCID:: PMC6334659

Abstract Article PDF–667K

Select item 484416918.

The Polymorphisms in LNK Gene Correlated to the Clinical Type of Myeloproliferative Neoplasms

Yan Chen, Fang Fang, Yang Hu, Qian Liu, Dingfang Bu, Mei Tan, Liusong Wu, Ping Zhu

PLoS One. 2016; 11(4): e0154183. Published online 2016 Apr 25. doi: 10.1371/journal.pone.0154183

PMCID:: PMC4844169

Abstract Article PDF–1.2M

Select item 466489319.

Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1

Timothy HT Cheng, Deborah Thompson, Jodie Painter, Tracy O’Mara, Maggie Gorman, Lynn Martin, Claire Palles, Angela Jones, Daniel D. Buchanan, Aung Ko Win, John Hopper, Mark Jenkins, Noralane M. Lindor, Polly A. Newcomb, Steve Gallinger, David Conti, Fred Schumacher, Graham Casey, Graham G Giles, Paul Pharoah, Julian Peto, Angela Cox, Anthony Swerdlow, Fergus Couch, Julie M Cunningham, Ellen L Goode, Stacey J Winham, Diether Lambrechts, Peter Fasching, Barbara Burwinkel, Hermann Brenner, Hiltrud Brauch, Jenny Chang-Claude, Helga B. Salvesen, Vessela Kristensen, Hatef Darabi, Jingmei Li, Tao Liu, Annika Lindblom, Per Hall, Magdalena Echeverry de Polanco, Monica Sans, Angel Carracedo, Sergi Castellvi-Bel, Augusto Rojas-Martinez, Samuel Aguiar Jnr, Manuel R. Teixeira, Alison M Dunning, Joe Dennis, Geoffrey Otton, Tony Proietto, Elizabeth Holliday, John Attia, Katie Ashton, Rodney J Scott, Mark McEvoy, Sean C Dowdy, Brooke L Fridley, Henrica MJ Werner, Jone Trovik, Tormund S Njolstad, Emma Tham, Miriam Mints, Ingo Runnebaum, Peter Hillemanns, Thilo Dörk, Frederic Amant, Stefanie Schrauwen, Alexander Hein, Matthias W Beckmann, Arif Ekici, Kamila Czene, Alfons Meindl, Manjeet K Bolla, Kyriaki Michailidou, Jonathan P Tyrer, Qin Wang, Shahana Ahmed, Catherine S Healey, Mitul Shah, Daniela Annibali, Jeroen Depreeuw, Nada A. Al-Tassan, Rebecca Harris, Brian F. Meyer, Nicola Whiffin, Fay J Hosking, Ben Kinnersley, Susan M. Farrington, Maria Timofeeva, Albert Tenesa, Harry Campbell, Robert W. Haile, Shirley Hodgson, Luis Carvajal-Carmona, Jeremy P. Cheadle, Douglas Easton, Malcolm Dunlop, Richard Houlston, Amanda Spurdle, Ian Tomlinson

Sci Rep. 2015; 5: 17369. Published online 2015 Dec 1. doi: 10.1038/srep17369

PMCID:: PMC4664893

Abstract Article PDF–862K

Select item 379051020.

Genetic loss of SH2B3 in acute lymphoblastic leukemia

Arianne Perez-Garcia, Alberto Ambesi-Impiombato, Michael Hadler, Isaura Rigo, Charles A. LeDuc, Kara Kelly, Chaim Jalas, Elisabeth Paietta, Janis Racevskis, Jacob M. Rowe, Martin S. Tallman, Maddalena Paganin, Giuseppe Basso, Wei Tong, Wendy K. Chung, Adolfo A. Ferrando

Blood. 2013 Oct 3; 122(14): 2425–2432. Prepublished online 2013 Aug 1. doi: 10.1182/blood-2013-05-500850

PMCID:: PMC3790510

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