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Select item 111970631.

Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis

Gerard W. Dougherty, Lawrence E. Ostrowski, Tabea Nöthe-Menchen, Johanna Raidt, Andre Schramm, Heike Olbrich, Weining Yin, Patrick R. Sears, Hong Dang, Amanda J. Smith, Achim G. Beule, Rim Hjeij, Niels Rutjes, Eric G. Haarman, Saskia M. Maas, Thomas W. Ferkol, Peadar G. Noone, Kenneth N. Olivier, Diana C. Bracht, Pascal Barbry, Laure-Emmanuelle Zaragosi, Morgane Fierville, Sabine Kliesch, Kai Wohlgemuth, Julia König, Sebastian George, Niki T. Loges, Agathe Ceppe, Matthew R. Markovetz, Hong Luo, Ting Guo, Hoda Rizk, Tarek Eldesoky, Katrin Dahlke, Karsten Boldt, Marius Ueffing, David B. Hill, Yuan-Ping Pang, Michael R. Knowles, Maimoona A. Zariwala, Heymut Omran

Am J Respir Crit Care Med. 2024 Jul 1; 210(1): 63–76. Published online 2024 Apr 16. doi: 10.1164/rccm.202308-1370OC

PMCID:: PMC11197063

Abstract Article PDF–2.8M

Select item 107255892.

Elevated level of serum human epididymis protein 4 (HE4) predicts disease severity and mortality in COVID-19 pneumonia

Renáta Sütő, Marianna Pócsi, Zsolt Szabó, Zsolt Fejes, Gergely Ivády, György Kerekes, Miklós Fagyas, Attila Nagy, Zoltán Szentkereszty, János Kappelmayer, Béla Nagy, Jr.

BMC Pulm Med. 2023; 23: 512. Published online 2023 Dec 16. doi: 10.1186/s12890-023-02811-y

PMCID:: PMC10725589

Abstract Article PDF–1.4M

Select item 93385683.

HE4 as a serum biomarker for the diagnosis of pelvic masses: a prospective, multicenter study in 965 patients

Elena Ioana Braicu, Catherine Linn Krause, Uwe Torsten, Herbert Mecke, Rolf Richter, Lars Hellmeyer, Malgorzata Lanowska, Bodo Müller, Elisa Koch, Janine Boenneß-Zaloum, Kerstin Ames, Radoslav Chekerov, Kati Hasenbein, Mathias Zimmermann, Mandy Mangler, Frank Chen, Rudolf Tauber, Jalid Sehouli

BMC Cancer. 2022; 22: 831. Published online 2022 Jul 30. doi: 10.1186/s12885-022-09887-5

PMCID:: PMC9338568

Abstract Article PDF–1.1M

Select item 91073484.

A bioinformatic analysis of WFDC2 (HE4) expression in high grade serous ovarian cancer reveals tumor-specific changes in metabolic and extracellular matrix gene expression

Nicole E. James, Megan Gura, Morgan Woodman, Richard N. Freiman, Jennifer R. Ribeiro

Med Oncol. 2022; 39(7): 71. Published online 2022 May 15. doi: 10.1007/s12032-022-01665-4

PMCID:: PMC9107348

Abstract Article PDF–3.5M

Select item 90970535.

Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease

Yuan Zhan, Jinkun Chen, Jixing Wu, Yiya Gu, Qian Huang, Zhesong Deng, Shanshan Chen, Xiaojie Wu, Yongman Lv, Zhilin Zeng, Jungang Xie

Respir Res. 2022; 23: 120. Published online 2022 May 12. doi: 10.1186/s12931-022-02040-7

PMCID:: PMC9097053

Abstract Article PDF–4.7M

Select item 86294666.

Serum Human Epididymis Protein-4 (HE4) - A novel Approach to Differentiate Malignant from benign Breast Tumors

K S S Sai Baba, Mohd Abdul Rehman, J Pradeep Kumar, Maira Fatima, G S N Raju, Shantveer G Uppin, Noorjahan Mohammed

Asian Pac J Cancer Prev. 2021 Aug; 22(8): 2509–2513. doi: 10.31557/APJCP.2021.22.8.2509

PMCID:: PMC8629466

Abstract Article PDF–340K

Select item 85783277.

Recurrence monitoring for ovarian cancer using a cell phone-integrated paper device to measure the ovarian cancer biomarker HE4/CRE ratio in urine

Emily C. Kight, Iftak Hussain, Audrey K. Bowden, Frederick R. Haselton

Sci Rep. 2021; 11: 21945. Published online 2021 Nov 9. doi: 10.1038/s41598-021-01544-4

PMCID:: PMC8578327

Abstract Article PDF–2.8M

Select item 84897638.

HE4 might be a more useful tumor biomarker to detect malignancy in patients with ovarian endometrioma when malignancy is suspected

Mariona Rius, Pere Fusté, Cristina Ros, Ángeles Martínez-Zamora, Cristian deGuirior, Meritxell Gracia, Eduard Mension, Francisco Carmona

J Int Med Res. 2021 Sep; 49(9): 03000605211047701. Published online 2021 Sep 30. doi: 10.1177/03000605211047701

PMCID:: PMC8489763

Abstract Article PDF–274K

Select item 82606789.

Elevated Serum Human Epididymis Protein 4 Is Associated With Disease Activity and Systemic Involvements in Primary Sjögren’s Syndrome

Jiali Chen, Feng Sun, Huizhang Bao, Liu Liang, Minghua Zhan, Haihong Yao, Jing He, Yudong Liu

Front Immunol. 2021; 12: 670642. Published online 2021 Jun 23. doi: 10.3389/fimmu.2021.670642

PMCID:: PMC8260678

Abstract Article PDF–1.6M

Select item 812706110.

Human epididymis protein 4 promotes P-glycoprotein-mediated chemoresistance in ovarian cancer cells through interactions with Annexin II

Qing Liu, Da-Wo Liu, Ming-Jun Zheng, Lu Deng, Hui-Min Wang, Shan Jin, Juan-Juan Liu, Ying-Ying Hao, Lian-Cheng Zhu, Bei Lin

Mol Med Rep. 2021 Jul; 24(1): 496. Published online 2021 May 5. doi: 10.3892/mmr.2021.12135

PMCID:: PMC8127061

Abstract Article PDF–2.9M

Select item 772108611.

High levels of human epididymis protein 4 mRNA and protein expression are associated with chemoresistance and a poor prognosis in pancreatic cancer

Ryotaro Ohkuma, Erica Yada, Shumpei Ishikawa, Daisuke Komura, Yutaro Kubota, Kazuyuki Hamada, Atsushi Horiike, Tomoyuki Ishiguro, Yuya Hirasawa, Hirotsugu Ariizumi, Midori Shida, Makoto Watanabe, Rie Onoue, Kiyohiro Ando, Junji Tsurutani, Kiyoshi Yoshimura, Tetsuro Sasada, Takeshi Aoki, Masahiko Murakami, Tomoko Norose, Nobuyuki Ohike, Masafumi Takimoto, Shinichi Kobayashi, Takuya Tsunoda, Satoshi Wada

Int J Oncol. 2021 Jan; 58(1): 57–69. Published online 2020 Jan 12. doi: 10.3892/ijo.2020.5147

PMCID:: PMC7721086

Abstract Article PDF–1.6M

Select item 765329012.

Role of Human Epididymis Protein 4 (HE4) in Determining Survival of Patients With Endometrial Cancer: A Meta-Analysis

Ying He, Jing Wang, Chun-Xing Ma, Yan-Hua Kang

Technol Cancer Res Treat. 2020; 19: 1533033820971660. Published online 2020 Nov 5. doi: 10.1177/1533033820971660

PMCID:: PMC7653290

Abstract Article PDF–987K

Select item 716092913.

Serum human epididymis protein 4 level as a predictor of clinical worsening in idiopathic pulmonary arterial hypertension: a pilot study

Qi Jin, Yi Tang, Zhihong Liu, Wenlin Xie, Qin Luo, Zhihui Zhao, Qing Zhao, Zhiwei Huang, Xue Yu, Lu Yan, Changming Xiong, Xinhai Ni, Yinkun Yan

BMC Cardiovasc Disord. 2020; 20: 175. Published online 2020 Apr 15. doi: 10.1186/s12872-020-01461-w

PMCID:: PMC7160929

Abstract Article PDF–648K

Select item 715498114.

Human Epididymis Protein 4 Levels in Neonates with Respiratory Disorder

Piotr Surmiak, Martyna Szymkowiak, Małgorzata Baumert

Biomed Res Int. 2020; 2020: 1509379. Published online 2020 Apr 2. doi: 10.1155/2020/1509379

PMCID:: PMC7154981

Abstract Article PDF–474K

Select item 699251915.

HE4 antigen-autoantibody complexes complement CA125 for detecting early stage ovarian cancer

Wei-Lei Yang, Zhen Lu, Jing Guo, Bryan M. Fellman, Jing Ning, Karen H. Lu, Usha Menon, Makoto Kobayashi, Samir Hanash, Joseph Celestino, Steven J. Skates, Robert C. Bast, Jr.

Cancer. Author manuscript; available in PMC 2021 Feb 15.

Published in final edited form as: Cancer. 2020 Feb 15; 126(4): 725–736. Published online 2019 Nov 12. doi: 10.1002/cncr.32582