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Select item 111212481.

MerTK Drives Proliferation and Metastatic Potential in Triple-Negative Breast Cancer

Mari Iida, Bridget E. Crossman, Kourtney L. Kostecki, Christine E. Glitchev, Carlene A. Kranjac, Madisen T. Crow, Jillian M. Adams, Peng Liu, Irene Ong, David T. Yang, Irene Kang, Ravi Salgia, Deric L. Wheeler

Int J Mol Sci. 2024 May; 25(10): 5109. Published online 2024 May 8. doi: 10.3390/ijms25105109

PMCID:: PMC11121248

Abstract Article PDF–13M

Select item 108692592.

Big data analytics for MerTK genomics reveals its double-edged sword functions in human diseases

Shijie Liu, Jinzi Wu, Daixuan Yang, Jianliang Xu, Hang Shi, Bingzhong Xue, Zufeng Ding

Redox Biol. 2024 Apr; 70: 103061. Published online 2024 Feb 5. doi: 10.1016/j.redox.2024.103061

PMCID:: PMC10869259

Abstract Article PDF–24M

Select item 104829773.

Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer

Kaisa E. Happonen, Patrick G. Burrola, Greg Lemke

Commun Biol. 2023; 6: 916. Published online 2023 Sep 7. doi: 10.1038/s42003-023-05287-y

PMCID:: PMC10482977

Abstract Article PDF–1.6M

Select item 99942074.

Mertk: An emerging target in cancer biology and immuno-oncology

Kevin C. Lahey, Varsha Gadiyar, Amanda Hill, Samuel Desind, Ziren Wang, Viralkumar Davra, Radhey Patel, Ahnaf Zaman, David Calianese, Raymond B. Birge

Int Rev Cell Mol Biol. Author manuscript; available in PMC 2023 Mar 8.

Published in final edited form as: Int Rev Cell Mol Biol. 2022; 368: 35–59. Published online 2022 May 5. doi: 10.1016/bs.ircmb.2022.04.004

PMCID:: PMC9994207

Abstract Article PDF–1.2M

Select item 96391425.

Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease

Sule Yavuz, Pascal Pucholt, Johanna K Sandling, Matteo Bianchi, Dag Leonard, Karin Bolin, Juliana Imgenberg-Kreuz, Maija-Leena Eloranta, Sergey V Kozyrev, Cristina M Lanata, Andreas Jönsen, Anders A Bengtsson, Christopher Sjöwall, Elisabet Svenungsson, Iva Gunnarsson, Solbritt Rantapää-Dahlqvist, ImmunoArray Development Consortium, DISSECT Consortium, Joanne Nititham, Lindsey A Criswell, Kerstin Lindblad-Toh, Lars Rönnblom

Lupus Sci Med. 2022; 9(1): e000752. Published online 2022 Nov 4. doi: 10.1136/lupus-2022-000752

PMCID:: PMC9639142

Abstract Article PDF–1.1M

Select item 96155586.

MERTK missense variants in three patients with retinitis pigmentosa

Federica E. Poli, Imran H. Yusuf, Penny Clouston, Morag Shanks, Jennifer Whitfield, Peter Charbel Issa, Robert E. MacLaren

Ophthalmic Genet. 2022 Aug 29 : 1–9. doi: 10.1080/13816810.2022.2113541 [Epub ahead of print]

PMCID:: PMC9615558

Abstract Article PDF–13M

Select item 93944537.

Mer Tyrosine Kinase (MERTK) modulates liver fibrosis progression and hepatocellular carcinoma development

Rosaria Maria Pipitone, Vincenza Calvaruso, Lorenza Di Marco, Francesca Di Salvo, Miriam Gaggianesi, Giulia Lupo, Rossella Zito, Claudia La Mantia, Matteo Ramazzotti, Salvatore Petta, Vito Di Marco, Antonio Craxì, Stefania Grimaudo

Front Immunol. 2022; 13: 926236. Published online 2022 Aug 8. doi: 10.3389/fimmu.2022.926236

PMCID:: PMC9394453

Abstract Article PDF–886K

Select item 84873088.

Mer tyrosine kinase as a possible link between resolution of inflammation and tissue fibrosis in IgG4-related disease

Lucrezia Rovati, Naoki Kaneko, Federica Pedica, Antonella Monno, Takashi Maehara, Cory Perugino, Marco Lanzillotta, Simone Pecetta, John H Stone, Claudio Doglioni, Angelo A Manfredi, Shiv Pillai, Emanuel Della-Torre

Rheumatology (Oxford) 2021 Oct; 60(10): 4929–4941. Published online 2021 Jan 29. doi: 10.1093/rheumatology/keab096

PMCID:: PMC8487308

Abstract Article PDF–1.7M

Select item 82296189.

MERTK-Mediated LC3-Associated Phagocytosis (LAP) of Apoptotic Substrates in Blood-Separated Tissues: Retina, Testis, Ovarian Follicles

Marina G. Yefimova, Celia Ravel, Antoine D. Rolland, Nicolas Bourmeyster, Bernard Jégou

Cells. 2021 Jun; 10(6): 1443. Published online 2021 Jun 9. doi: 10.3390/cells10061443

PMCID:: PMC8229618

Abstract Article PDF–20M

Select item 814981310.

Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages

Florian Wanke, Simon Gutbier, Anna Rümmelin, Malte Steinberg, Lindsey D. Hughes, Mascha Koenen, Juliana Komuczki, Daniel Regan-Komito, Sagie Wagage, Julia Hesselmann, Ralf Thoma, Doris Brugger, Tony Christopeit, Hayian Wang, Floriane Point, Remy Hallet, Sourav Ghosh, Carla V. Rothlin, Christoph Patsch, Barbara Geering

Cell Death Dis. 2021 Jun; 12(6): 538. Published online 2021 May 25. doi: 10.1038/s41419-021-03770-0

PMCID:: PMC8149813

Abstract Article PDF–2.5M

Select item 799293311.

Differential polarization and the expression of efferocytosis receptor MerTK on M1 and M2 macrophages isolated from coronary artery disease patients

Fatin Najiah Mohd Idrus, Nurul Shuhadah Ahmad, Chee Hock Hoe, Maryam Azlan, Farisha Alia Norfuad, Zurkurnai Yusof, Wan Yus Haniff Wan Isa, Akbar Ali Mohamed Ali, Get Bee Yvonne-Tee

BMC Immunol. 2021; 22: 21. Published online 2021 Mar 24. doi: 10.1186/s12865-021-00410-2

PMCID:: PMC7992933

Abstract Article PDF–924K

Select item 776612912.

Bi-Allelic Pathogenic Variations in MERTK Including Deletions Are Associated with an Early Onset Progressive Form of Retinitis Pigmentosa

Cathrine Jespersgaard, Mette Bertelsen, Farah Arif, Helene Gry Gellert-Kristensen, Mingyan Fang, Hanne Jensen, Thomas Rosenberg, Zeynep Tümer, Lisbeth Birk Møller, Karen Brøndum-Nielsen, Karen Grønskov

Genes (Basel) 2020 Dec; 11(12): 1517. Published online 2020 Dec 18. doi: 10.3390/genes11121517

PMCID:: PMC7766129

Abstract Article PDF–1.3M

Select item 770230113.

A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding

Alexander Pflug, Marianne Schimpl, J. Willem M. Nissink, Ross C. Overman, Philip B. Rawlins, Caroline Truman, Elizabeth Underwood, Juli Warwicker, Jon Winter-Holt, William McCoull

Biochem J. 2020 Nov 27; 477(22): 4443–4452. Prepublished online 2020 Oct 29. Published online 2020 Nov 27. doi: 10.1042/BCJ20200735

PMCID:: PMC7702301

Abstract Article PDF–1.8M

Select item 754625114.

Expression of TAM-R in Human Immune Cells and Unique Regulatory Function of MerTK in IL-10 Production by Tolerogenic DC

Paul Giroud, Sarah Renaudineau, Laura Gudefin, Alexandre Calcei, Thierry Menguy, Caroline Rozan, Jacques Mizrahi, Christophe Caux, Vanessa Duong, Jenny Valladeau-Guilemond

Front Immunol. 2020; 11: 564133. Published online 2020 Sep 25. doi: 10.3389/fimmu.2020.564133

PMCID:: PMC7546251

Abstract Article PDF–2.6M

Select item 706637515.

MERTK-Dependent Ensheathment of Photoreceptor Outer Segments by Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium

Seba Almedawar, Katerina Vafia, Sven Schreiter, Katrin Neumann, Shahryar Khattak, Thomas Kurth, Marius Ader, Mike O. Karl, Stephen H. Tsang, Elly M. Tanaka

Stem Cell Reports. 2020 Mar 10; 14(3): 374–389. Published online 2020 Mar 10. doi: 10.1016/j.stemcr.2020.02.004

PMCID:: PMC7066375

Abstract Article PDF–8.2M

Select item 689482416.

The role of endothelial MERTK during the inflammatory response in lungs

Yitong Li, Erika S. Wittchen, Elizabeth Monaghan-Benson, Cornelia Hahn, H. Shelton Earp, Claire M. Doerschuk, Keith Burridge

PLoS One. 2019; 14(12): e0225051. Published online 2019 Dec 5. doi: 10.1371/journal.pone.0225051

PMCID:: PMC6894824

Abstract Article PDF–3.8M

Select item 646565417.

Targeted next generation sequencing identified novel loss‐of‐function mutations in MERTK gene in Chinese patients with retinitis pigmentosa

Song Liu, Jian Gang Bi, Yunlong Hu, Donge Tang, Bo Li, Peng Zhu, Wujian Peng, Dong Du, Huiyan He, Jun Zeng, Yong Dai

Mol Genet Genomic Med. 2019 Apr; 7(4): e00577. Published online 2019 Feb 20. doi: 10.1002/mgg3.577

PMCID:: PMC6465654

Abstract Article PDF–457K

Select item 621551118.

MERTK mediates intrinsic and adaptive resistance to AXL-targeting agents

Nellie K. McDaniel, Christopher T. Cummings, Mari Iida, Justus Hülse, Hannah E. Pearson, Eleana Vasileiadi, Rebecca E. Parker, Rachel A. Orbuch, Olivia J. Ondracek, Noah B. Welke, Grace Hye-Hyun Kang, Kurtis D. Davies, Xiaodong Wang, Stephen V. Frye, H. Shelton Earp, Paul M. Harari, Randall J. Kimple, Deborah DeRyckere, Douglas K. Graham, Deric L. Wheeler

Mol Cancer Ther. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: Mol Cancer Ther. 2018 Nov; 17(11): 2297–2308. Published online 2018 Aug 9. doi: 10.1158/1535-7163.MCT-17-1239

PMCID:: PMC6215511

Abstract Article PDF–1.5M

Select item 619786419.

Non-homologous recombination between Alu and LINE-1 repeats results in a 91 kb deletion in MERTK causing severe retinitis pigmentosa

Frida Jonsson, Marie Burstedt, Therese G. Kellgren, Irina Golovleva

Mol Vis. 2018; 24: 667–678. Published online 2018 Oct 18.

PMCID:: PMC6197864

Abstract Article PDF–3.1M

Select item 617111020.

MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity

Bishuang Cai, Canan Kasikara, Amanda C. Doran, Rajasekhar Ramakrishnan, Raymond B. Birge, Ira Tabas

Sci Signal. Author manuscript; available in PMC 2019 Mar 25.

Published in final edited form as: Sci Signal. 2018 Sep 25; 11(549): eaar3721. Published online 2018 Sep 25. doi: 10.1126/scisignal.aar3721

PMCID:: PMC6171110

Abstract Article PDF–1.7M

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