PMC Links for Gene (Select 10494) - PMC

Xiaokan Zhang, Bryan Z. Wang, Michael Kim, Trevor R. Nash, Bohao Liu, Jenny Rao, Roberta Lock, Manuel Tamargo, Rajesh Kumar Soni, John Belov, Eric Li, Gordana Vunjak-Novakovic, Barry Fine

Cell Rep. Author manuscript; available in PMC 2022 Sep 6.

Published in final edited form as: Cell Rep. 2022 Aug 16; 40(7): 111203. doi: 10.1016/j.celrep.2022.111203

PMCID:: PMC9446420

Abstract Article PDF–813K

Select item 86881845.

Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways

Yeshwant Kurhe, Mara Caputo, Emmelie Cansby, Ying Xia, Sima Kumari, Sumit Kumar Anand, Brian W. Howell, Hanns-Ulrich Marschall, Margit Mahlapuu

Cell Mol Gastroenterol Hepatol. 2022; 13(2): 405–423. Published online 2021 Oct 6. doi: 10.1016/j.jcmgh.2021.09.018

PMCID:: PMC8688184

Abstract Article PDF–13M

Select item 78197476.

Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease

Emmelie Cansby, Mara Caputo, Lei Gao, Nagaraj M. Kulkarni, Annika Nerstedt, Marcus Ståhlman, Jan Borén, Rando Porosk, Ursel Soomets, Matteo Pedrelli, Paolo Parini, Hanns-Ulrich Marschall, Jenny Nyström, Brian W. Howell, Margit Mahlapuu

JCI Insight. 2020 Dec 17; 5(24): e140483. Published online 2020 Dec 17. doi: 10.1172/jci.insight.140483

PMCID:: PMC7819747

Abstract Article PDF–69M

Select item 64493797.

Identification of the kinase STK25 as an upstream activator of LATS signaling

Sanghee Lim, Nicole Hermance, Tenny Mudianto, Hatim M. Mustaly, Ian Paolo Morelos Mauricio, Marc A. Vittoria, Ryan J. Quinton, Brian W. Howell, Hauke Cornils, Amity L. Manning, Neil J. Ganem

Nat Commun. 2019; 10: 1547. Published online 2019 Apr 4. doi: 10.1038/s41467-019-09597-w

PMCID:: PMC6449379

Abstract Article PDF–2.9M

Select item 4521838.

Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway.

C M Pombo, J V Bonventre, A Molnar, J Kyriakis, T Force

EMBO J. 1996 Sep 2; 15(17): 4537–4546.

PMCID:: PMC452183

Summary Page Browse PDF–2.5M

Select item 63590559.

p21^WAF1/Cip1 Regulation by hYSK1 Activates SP-1 Transcription Factor and Increases MMP-2 Expression under Hypoxic Conditions

Mee-Hyun Lee, Joydeb Kumar Kundu, Bu Young Choi

Int J Mol Sci. 2019 Jan; 20(2): 310. Published online 2019 Jan 14. doi: 10.3390/ijms20020310

PMCID:: PMC6359055

Abstract Article PDF–2.8M

Select item 427062810.

Differential expression of MST4, STK25 and PDCD10 between benign prostatic hyperplasia and prostate cancer

Heyu Zhang, Xi Ma, Saihui Peng, Xu Nan, Hongshan Zhao

Int J Clin Exp Pathol. 2014; 7(11): 8105–8111. Published online 2014 Oct 15.

PMCID:: PMC4270628

Abstract Article PDF–655K

Select item 343619111.

STK25 Protein Mediates TrkA and CCM2 Protein-dependent Death in Pediatric Tumor Cells of Neural Origin

Barbara Costa, Michelle J. Kean, Volker Ast, James D. R. Knight, Alice Mett, Zehava Levy, Derek F. Ceccarelli, Beatriz Gonzalez Badillo, Roland Eils, Rainer König, Anne-Claude Gingras, Mike Fainzilber

J Biol Chem. 2012 Aug 24; 287(35): 29285–29289. Published online 2012 Jul 10. doi: 10.1074/jbc.C112.345397

PMCID:: PMC3436191

Abstract Article PDF–910K

Select item 313707912.

CCM3/PDCD10 Heterodimerizes with Germinal Center Kinase III (GCKIII) Proteins Using a Mechanism Analogous to CCM3 Homodimerization

Derek F. Ceccarelli, Rob C. Laister, Vikram Khipple Mulligan, Michelle J. Kean, Marilyn Goudreault, Ian C. Scott, W. Brent Derry, Avijit Chakrabartty, Anne-Claude Gingras, Frank Sicheri

J Biol Chem. 2011 Jul 15; 286(28): 25056–25064. Published online 2011 May 11. doi: 10.1074/jbc.M110.213777

PMCID:: PMC3137079

Abstract Article PDF–2.4M

Select item 310198913.

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Beatrice M Filippi, Paola de los Heros, Youcef Mehellou, Iva Navratilova, Robert Gourlay, Maria Deak, Lorna Plater, Rachel Toth, Elton Zeqiraj, Dario R Alessi

EMBO J. 2011 May 4; 30(9): 1730–1741. Published online 2011 Mar 18. doi: 10.1038/emboj.2011.78

PMCID:: PMC3101989

Abstract Article PDF–740K

Select item 217206814.

YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3ζ

Christian Preisinger, Benjamin Short, Veerle De Corte, Erik Bruyneel, Alexander Haas, Robert Kopajtich, Jan Gettemans, Francis A. Barr

J Cell Biol. 2004 Mar 29; 164(7): 1009–1020. doi: 10.1083/jcb.200310061

PMCID:: PMC2172068

Abstract Article PDF–4.9M

Select item 291218115.

CCM3 signaling through sterile 20–like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

Xiangjian Zheng, Chong Xu, Annarita Di Lorenzo, Benjamin Kleaveland, Zhiying Zou, Christoph Seiler, Mei Chen, Lan Cheng, Jiping Xiao, Jie He, Michael A. Pack, William C. Sessa, Mark L. Kahn

J Clin Invest. 2010 Aug 2; 120(8): 2795–2804. Published online 2010 Jul 1. doi: 10.1172/JCI39679

PMCID:: PMC2912181

Abstract Article PDF–4.6M

Select item 182889516.

A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

Greg M. Findlay, Lijun Yan, Julia Procter, Virginie Mieulet, Richard F. Lamb

Biochem J. 2007 Apr 1; 403(Pt 1): 13–20. Prepublished online 2007 Jan 26. Published online 2007 Mar 13. doi: 10.1042/BJ20061881

PMCID:: PMC1828895

Abstract Article PDF–551K

Select item 295191017.

Signal Transduction Protein Array Analysis Links LRRK2 to Ste20 Kinases and PKC Zeta That Modulate Neuronal Plasticity

Susanne Zach, Sandra Felk, Frank Gillardon

PLoS One. 2010; 5(10): e13191. Published online 2010 Oct 7. doi: 10.1371/journal.pone.0013191

PMCID:: PMC2951910

Abstract Article PDF–870K

Select item 332287518.

Adaptor Protein Cerebral Cavernous Malformation 3 (CCM3) Mediates Phosphorylation of the Cytoskeletal Proteins Ezrin/Radixin/Moesin by Mammalian Ste20-4 to Protect Cells from Oxidative Stress

Miguel Fidalgo, Ana Guerrero, María Fraile, Cristina Iglesias, Celia M. Pombo, Juan Zalvide

J Biol Chem. 2012 Mar 30; 287(14): 11556–11565. Published online 2012 Jan 30. doi: 10.1074/jbc.M111.320259

PMCID:: PMC3322875

Abstract Article PDF–2.7M

Select item 262100419.

A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein

Marilyn Goudreault, Lisa M. D’Ambrosio, Michelle J. Kean, Michael J. Mullin, Brett G. Larsen, Amy Sanchez, Sidharth Chaudhry, Ginny I. Chen, Frank Sicheri, Alexey I. Nesvizhskii, Ruedi Aebersold, Brian Raught, Anne-Claude Gingras

Mol Cell Proteomics. 2009 Jan; 8(1): 157–171. doi: 10.1074/mcp.M800266-MCP200