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Select item 96323121.

DLL3 as an Emerging Target for the Treatment of Neuroendocrine Neoplasms

James Yao, Emily Bergsland, Rahul Aggarwal, Ana Aparicio, Himisha Beltran, Judy S Crabtree, Christine L Hann, Toni Ibrahim, Lauren A Byers, Hironobu Sasano, John Umejiego, Marianne Pavel

Oncologist. 2022 Nov; 27(11): 940–951. Published online 2022 Aug 19. doi: 10.1093/oncolo/oyac161

PMCID:: PMC9632312

Abstract Article PDF–4.3M

Select item 83539412.

Delta‐like canonical Notch ligand 3 as a potential therapeutic target in malignancies: A brief overview

Kentaro Matsuo, Kohei Taniguchi, Hiroki Hamamoto, Yosuke Inomata, Kazumasa Komura, Tomohito Tanaka, Sang‐Woong Lee, Kazuhisa Uchiyama

Cancer Sci. 2021 Aug; 112(8): 2984–2992. Published online 2021 Jun 30. doi: 10.1111/cas.15017

PMCID:: PMC8353941

Abstract Article PDF–485K

Select item 74710443.

DLL3 expression is a predictive marker of sensitivity to adjuvant chemotherapy for pulmonary LCNEC

Hiroyuki Ogawa, Yasuhiro Sakai, Wataru Nishio, Yusuke Fujibayashi, Megumi Nishikubo, Yuki Nishioka, Shinya Tane, Yoshitaka Kitamura, Tamotsu Sudo, Toshiko Sakuma, Masahiro Yoshimura

Thorac Cancer. 2020 Sep; 11(9): 2561–2569. Published online 2020 Jul 21. doi: 10.1111/1759-7714.13574

PMCID:: PMC7471044

Abstract Article PDF–1.9M

Select item 67786284.

Delta‐like 3 localizes to neuroendocrine cells and plays a pivotal role in gastrointestinal neuroendocrine malignancy

Kentaro Matsuo, Kohei Taniguchi, Hiroki Hamamoto, Yuko Ito, Sugiko Futaki, Yosuke Inomata, Takafumi Shima, Mitsuhiro Asakuma, Sang‐Woong Lee, Keitaro Tanaka, Junji Okuda, Yoichi Kondo, Kazuhisa Uchiyama

Cancer Sci. 2019 Oct; 110(10): 3122–3131. Published online 2019 Aug 14. doi: 10.1111/cas.14157

PMCID:: PMC6778628

Abstract Article PDF–2.9M

Select item 65825665.

DLL3: an emerging target in small cell lung cancer

Dwight H. Owen, Michael J. Giffin, Julie M. Bailis, Marie-Anne Damiette Smit, David P. Carbone, Kai He

J Hematol Oncol. 2019; 12: 61. Published online 2019 Jun 18. doi: 10.1186/s13045-019-0745-2

PMCID:: PMC6582566

Abstract Article PDF–1.8M

Select item 65256336.

Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer

Loredana Puca, Katie Gavyert, Verena Sailer, Vincenza Conteduca, Etienne Dardenne, Michael Sigouros, Kumiko Isse, Megan Kearney, Aram Vosoughi, Luisa Fernandez, Heng Pan, Samaneh Motanagh, Judy Hess, Adam J. Donoghue, Andrea Sboner, Yuzhuo Wang, Ryan Dittamore, David Rickman, David M. Nanus, Scott T. Tagawa, Olivier Elemento, Juan Miguel Mosquera, Laura Saunders, Himisha Beltran

Sci Transl Med. Author manuscript; available in PMC 2019 May 18.

Published in final edited form as: Sci Transl Med. 2019 Mar 20; 11(484): eaav0891. doi: 10.1126/scitranslmed.aav0891

PMCID:: PMC6525633

Abstract Article PDF–1.3M

Select item 63334667.

Transcriptomic and protein analysis of small cell bladder cancer (SCBC) identifies prognostic biomarkers and DLL3 as a relevant therapeutic target

Vadim S Koshkin, Jorge A Garcia, Jordan Reynolds, Paul Elson, Cristina Magi-Galluzzi, Jesse K. McKenney, Kumiko Isse, Evan Bishop, Laura R Saunders, Aysegul Balyimez, Summya Rashid, Ming Hu, Andrew J Stephenson, Amr F Fergany, Byron H Lee, Georges-Pascal Haber, Afshin Dowlati, Timothy Gilligan, Moshe C Ornstein, Brian I Rini, Mohamed E Abazeed, Omar Y Mian, Petros Grivas

Clin Cancer Res. Author manuscript; available in PMC 2019 Jul 1.

Published in final edited form as: Clin Cancer Res. 2019 Jan 1; 25(1): 210–221. Published online 2018 Oct 16. doi: 10.1158/1078-0432.CCR-18-1278

PMCID:: PMC6333466

Abstract Article PDF–877K

Select item 63200868.

Upregulated delta-like protein 3 expression is a diagnostic and prognostic marker in endometrial cancer: A retrospective study

Juan Wang, Kaishuo Zhang, Zi Liu, Tao Wang, Fan Shi, Yingbing Zhang, Jin Su, Yina Jia

Medicine (Baltimore) 2018 Dec; 97(51): e13442. Published online 2018 Dec 21. doi: 10.1097/MD.0000000000013442

PMCID:: PMC6320086

Abstract Article PDF–504K

Select item 58590379.

Delta-like 3 is silenced by HBx via histone acetylation in HBV-associated HCCs

Hiroki Hamamoto, Kentaro Maemura, Kentaro Matsuo, Kohei Taniguchi, Yoshihisa Tanaka, Sugiko Futaki, Atsushi Takeshita, Akira Asai, Michihiro Hayashi, Yoshinobu Hirose, Yoichi Kondo, Kazuhisa Uchiyama

Sci Rep. 2018; 8: 4842. Published online 2018 Mar 19. doi: 10.1038/s41598-018-23318-1

PMCID:: PMC5859037

Abstract Article PDF–1.7M

Select item 526585710.

Five known tagging DLL3 SNPs are not associated with congenital scoliosis: A case–control association study in a Chinese Han population

Yong Yang, Bing-Qiang Wang, Zhi-Hong Wu, Hai-Yan Zhang, Gui-Xing Qiu, Jian-Xiong Shen, Jian-Guo Zhang, Yu Zhao, Yi-Peng Wang, Qi Fei

Medicine (Baltimore) 2016 Jul; 95(30): e4347. Published online 2016 Jul 29. doi: 10.1097/MD.0000000000004347

PMCID:: PMC5265857

Abstract Article PDF–244K

Select item 359745711.

Delta-like 3 is silenced by methylation and induces apoptosis in human hepatocellular carcinoma

KENTARO MAEMURA, HIROHIDE YOSHIKAWA, KAZUTAKE YOKOYAMA, TERUO UENO, HITOMI KUROSE, KAZUHISA UCHIYAMA, YOSHINORI OTSUKI

Int J Oncol. 2013 Mar; 42(3): 817–822. Published online 2013 Jan 17. doi: 10.3892/ijo.2013.1778

PMCID:: PMC3597457

Abstract Article PDF–420K

Select item 173547512.

Novel mutations in DLL3, a somitogenesis gene encoding a ligand for the Notch signalling pathway, cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis

P Turnpenny, N Whittock, J Duncan, S Dunwoodie, K Kusumi, S Ellard

J Med Genet. 2003 May; 40(5): 333–339. doi: 10.1136/jmg.40.5.333

PMCID:: PMC1735475

Summary PDF–240K

Select item 137808813.

A gene for autosomal recessive spondylocostal dysostosis maps to 19q13.1-q13.3.

P D Turnpenny, M P Bulman, T M Frayling, T K Abu-Nasra, C Garrett, A T Hattersley, S Ellard

Am J Hum Genet. 1999 Jul; 65(1): 175–182. doi: 10.1086/302464

PMCID:: PMC1378088

Summary PDF–489K

Select item 880725614.

ASCL1 and DLL3 expressions and their clinicopathological implications in surgically resected pure small cell lung cancer: A study of 247 cases from the National Cancer Center of China

Chunfang Hu, Jiyan Dong, Li Liu, Jingbo Liu, Xujie Sun, Fei Teng, Xin Wang, Jianming Ying, Junling Li, Puyuan Xing, Lin Yang

Thorac Cancer. 2022 Feb; 13(3): 338–345. Published online 2021 Dec 20. doi: 10.1111/1759-7714.14249

PMCID:: PMC8807256

Abstract Article PDF–1.5M

Select item 736558915.

Cell surface Notch ligand DLL3 is a therapeutic target in isocitrate dehydrogenase mutant glioma

Marissa Spino, Sylvia C. Kurz, Luis Chiriboga, Jonathan Serrano, Briana Zeck, Namita Sen, Seema Patel, Guomiao Shen, Varshini Vasudevaraja, Carter M. Suryadevara, Joshua Frenster, Kensuke Tateishi, Hiroaki Wakimoto, Rajan Jain, Howard A. Riina, Theodore P. Nicolaides, Erik P. Sulman, Daniel P. Cahill, John G. Golfinos, Kumiko Isse, Laura R. Saunders, David Zagzag, Dimitris Placantonakis, Matija Snuderl, Andrew S. Chi

Clin Cancer Res. Author manuscript; available in PMC 2020 Jul 16.

Published in final edited form as: Clin Cancer Res. 2019 Feb 15; 25(4): 1261–1271. Published online 2018 Nov 5. doi: 10.1158/1078-0432.CCR-18-2312

PMCID:: PMC7365589

Abstract Article PDF–699K

Select item 650101016.

DLL3 regulates the migration and invasion of small cell lung cancer by modulating Snail

Megumi Furuta, Hajime Kikuchi, Tetsuaki Shoji, Yuta Takashima, Eiki Kikuchi, Junko Kikuchi, Ichiro Kinoshita, Hirotoshi Dosaka‐Akita, Jun Sakakibara‐Konishi

Cancer Sci. 2019 May; 110(5): 1599–1608. Published online 2019 Apr 13. doi: 10.1111/cas.13997

PMCID:: PMC6501010

Abstract Article PDF–991K

Select item 824656917.

Investigation of Candidate Genes and Pathways in Basal/TNBC Patients by Integrated Analysis

Qi Liu, Xiang Song, Zhaoyun Liu, Zhiyong Yu

Technol Cancer Res Treat. 2021; 20: 15330338211019506. Published online 2021 Jun 29. doi: 10.1177/15330338211019506

PMCID:: PMC8246569

Abstract Article PDF–2.2M

Select item 813291218.

TTF-1 and c-MYC-defined Phenotypes of Large Cell Neuroendocrine Carcinoma and Delta-like Protein 3 Expression for Treatment Selection

Aya Miyagawa-Hayashino, Satoru Okada, Naoko Takeda-Miyata, Yasutoshi Takashima, Tadaaki Yamada, Yoshizumi Takemura, Junji Uchino, Masayoshi Inoue, Koichi Takayama, Eiichi Konishi

Appl Immunohistochem Mol Morphol. 2021 Apr; 29(4): 313–320. Published online 2020 Oct 7. doi: 10.1097/PAI.0000000000000875

PMCID:: PMC8132912

Abstract Article PDF–493K

Select item 251622219.

The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity

Sara Farrah Heuss, Delphine Ndiaye-Lobry, Emmanuelle M. Six, Alain Israël, Frédérique Logeat

Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32): 11212–11217. Published online 2008 Aug 1. doi: 10.1073/pnas.0800695105

PMCID:: PMC2516222

Abstract Article PDF–961K

Select item 303170320.

Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph

Delphine Casabonne, Oscar Reina, Yolanda Benavente, Nikolaus Becker, Marc Maynadié, Lenka Foretová, Pierluigi Cocco, Anna González-Neira, Alexandra Nieters, Paolo Boffetta, Jaap M. Middeldorp, Silvia de Sanjose

Haematologica. 2011 Feb; 96(2): 323–327. Published online 2010 Nov 3. doi: 10.3324/haematol.2010.031161

PMCID:: PMC3031703

Abstract Article PDF–401K

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