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Select item 79484721.

Structural basis for antigen recognition by methylated lysine–specific antibodies

Misaki Ishii, Makoto Nakakido, Jose M.M. Caaveiro, Daisuke Kuroda, C.J. Okumura, Toshiaki Maruyama, Kevin Entzminger, Kouhei Tsumoto

J Biol Chem. 2021 Jan-Jun; 296: 100176. Published online 2020 Dec 17. doi: 10.1074/jbc.RA120.015996

PMCID:: PMC7948472

Abstract Article PDF–5.5M

Select item 57848282.

Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2)

Syed Ahmad, Valentine R. St Hilaire, Srinivasa R. Dandepally, Gary L. Johnson, Alfred L. Williams, John E. Scott

Biochem Biophys Res Commun. Author manuscript; available in PMC 2019 Jan 29.

Published in final edited form as: Biochem Biophys Res Commun. 2018 Jan 29; 496(1): 205–211. Published online 2018 Jan 5. doi: 10.1016/j.bbrc.2018.01.027

PMCID:: PMC5784828

Abstract Article PDF–737K

Select item 41218373.

EBV microRNA BART 18-5p targets MAP3K2 to facilitate persistence in vivo by inhibiting viral replication in B cells

Jin Qiu, David A. Thorley-Lawson

Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30): 11157–11162. Published online 2014 Jul 10. doi: 10.1073/pnas.1406136111

PMCID:: PMC4121837

Abstract Article PDF–1.1M

Select item 39609224.

MEKK2 Regulates Focal Adhesion Stability and Motility in Invasive Breast Cancer Cells

Ahmed A. Mirza, Michael P. Kahle, Magdalene Ameka, Edward M. Campbell, Bruce D. Cuevas

Biochim Biophys Acta. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: Biochim Biophys Acta. 2014 May; 1843(5): 945–954. Published online 2014 Jan 31. doi: 10.1016/j.bbamcr.2014.01.029

PMCID:: PMC3960922

Abstract Article PDF–940K

Select item 100502645.

CircHSPG2 knockdown attenuates hypoxia-induced apoptosis, inflammation, and oxidative stress in human AC16 cardiomyocytes by regulating the miR-1184/MAP3K2 axis

Liu Huang, Bingyan Guo, Jie Yan, Huiqing Wei, Suyun Liu, Yongjun Li

Cell Stress Chaperones. 2023 Mar; 28(2): 177–190. Published online 2023 Feb 21. doi: 10.1007/s12192-023-01328-x

PMCID:: PMC10050264

Abstract Article PDF–7.2M

Select item 94172406.

miRNA-338-3p inhibits the migration, invasion and proliferation of human lung adenocarcinoma cells by targeting MAP3K2

Bo Zhang, Dongchang Wang, Yuanyuan Wang, Gang Chen

Aging (Albany NY) 2022 Aug 15; 14(15): 6094–6110. Published online 2022 Aug 3. doi: 10.18632/aging.204198

PMCID:: PMC9417240

Abstract Article PDF–1.9M

Select item 66254597.

Analysis of potential functional significance of microRNA-3613-3p in human umbilical vein endothelial cells affected by heat stress

Jie Liu, Xuan Han, Guoguo Zhu, Shixin Liu, Qiping Lu, Zhongzhi Tang

Mol Med Rep. 2019 Aug; 20(2): 1846–1856. Published online 2019 Jun 11. doi: 10.3892/mmr.2019.10376

PMCID:: PMC6625459

Abstract Article PDF–996K

Select item 40032988.

Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2

Guang-yao Kong, Jun-ping Zhang, Shuai Zhang, Chang-liang Shan, Li-hong Ye, Xiao-dong Zhang

Acta Pharmacol Sin. 2011 Sep; 32(9): 1173–1180. Published online 2011 Aug 1. doi: 10.1038/aps.2011.52

PMCID:: PMC4003298

Abstract Article PDF–4.3M

Select item 32977229.

Defining MAP3Kinases Required for MDA-MB-231 Cell Tumor Growth and Metastasis

Mark R. Cronan, Kazuhiro Nakamura, Nancy L. Johnson, Deborah A. Granger, Bruce D. Cuevas, Jian-Guo Wang, Nigel Mackman, John E. Scott, Henrik G. Dohlman, Gary L. Johnson

Oncogene. Author manuscript; available in PMC 2013 Feb 23.

Published in final edited form as: Oncogene. 2012 Aug 23; 31(34): 3889–3900. Published online 2011 Dec 5. doi: 10.1038/onc.2011.544

PMCID:: PMC3297722

Abstract Article PDF–1.6M

Select item 116883610.

Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation

Jinke Cheng, Dongyu Zhang, Kihwan Kim, Yingxin Zhao, Yingming Zhao, Bing Su

Mol Cell Biol. 2005 Jul; 25(14): 5955–5964. doi: 10.1128/MCB.25.14.5955-5964.2005

PMCID:: PMC1168836

Abstract Article PDF–408K

Select item 31402411.

MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells

Timothy P. Garrington, Tamotsu Ishizuka, Philip J. Papst, Kosuke Chayama, Saiphone Webb, Toshiaki Yujiri, Weiyong Sun, Sue Sather, David M. Russell, Spencer B. Gibson, Gordon Keller, Erwin W. Gelfand, Gary L. Johnson

EMBO J. 2000 Oct 16; 19(20): 5387–5395. doi: 10.1093/emboj/19.20.5387

PMCID:: PMC314024

Abstract Article PDF–596K

Select item 23259612.

Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase.

Z Wu, J Wu, E Jacinto, M Karin

Mol Cell Biol. 1997 Dec; 17(12): 7407–7416. doi: 10.1128/mcb.17.12.7407

PMCID:: PMC232596

Summary PDF–1.2M

Select item 798126413.

Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers

Diana Monsivais, Yasmin Vasquez, Fengju Chen, Yiqun Zhang, Darshan S. Chandrashekar, John C. Faver, Ramya P. Masand, Michael E. Scheurer, Sooryanarayana Varambally, Martin M. Matzuk, Chad J. Creighton

Oncogene. Author manuscript; available in PMC 2021 Aug 24.

Published in final edited form as: Oncogene. 2021 Mar; 40(11): 2081–2095. Published online 2021 Feb 24. doi: 10.1038/s41388-021-01681-0

PMCID:: PMC7981264

Abstract Article PDF–2.6M

Select item 765822014.

MEKK2 mediates aberrant ERK activation in neurofibromatosis type I

Seoyeon Bok, Dong Yeon Shin, Alisha R. Yallowitz, Mark Eiseman, Michelle Cung, Ren Xu, Na Li, Jun Sun, Alfred L. Williams, John E. Scott, Bing Su, Jae-Hyuck Shim, Matthew B. Greenblatt

Nat Commun. 2020; 11: 5704. Published online 2020 Nov 11. doi: 10.1038/s41467-020-19555-6

PMCID:: PMC7658220

Abstract Article PDF–3.2M

Select item 727804415.

MIR205HG acts as a ceRNA to expedite cell proliferation and progression in lung squamous cell carcinoma via targeting miR-299-3p/MAP3K2 axis

Limin Liu, Yulei Li, Ruifang Zhang, Chun Li, Jing Xiong, Yuan Wei

BMC Pulm Med. 2020; 20: 163. Published online 2020 Jun 8. doi: 10.1186/s12890-020-1174-2

PMCID:: PMC7278044

Abstract Article PDF–4.6M

Select item 446753416.

MEKK2 Regulates Paxillin Ubiquitylation and Localization in MDA-MB 231 Breast Cancer Cells

Magdalene Ameka, Michael P. Kahle, Mathew Perez-Neut, Saverio Gentile, Ahmed A. Mirza, Bruce D. Cuevas

Biochem J. Author manuscript; available in PMC 2015 Nov 15.

Published in final edited form as: Biochem J. 2014 Nov 15; 464(1): 99–108. doi: 10.1042/BJ20140420

PMCID:: PMC4467534

Abstract Article PDF–1.8M

Select item 439663217.

Restoration of MiR-17/20a in Solid Tumor Cells Enhances the Natural Killer Cell Antitumor Activity by Targeting Mekk2

Hong Jiang, Ping Wang, Xiaohua Li, Qilong Wang, Zhong-Bin Deng, Xiaoying Zhuang, Jingyao Mu, Lifeng Zhang, Baomei Wang, Juan Yan, Donald Miller, Huang-Ge Zhang

Cancer Immunol Res. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: Cancer Immunol Res. 2014 Aug; 2(8): 789–799. Published online 2014 May 6. doi: 10.1158/2326-6066.CIR-13-0162