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Select item 110860331.

MTHFD2-mediated redox homeostasis promotes gastric cancer progression under hypoxic conditions

Hai-Yu Mo, Ruo-Bing Wang, Meng-Yao Ma, Yi Zhang, Xin-Yu Li, Wang-Rong Wen, Yi Han, Tian Tian

Redox Rep. 2024; 29(1): 2345455. Published online 2024 May 9. doi: 10.1080/13510002.2024.2345455

PMCID:: PMC11086033

Abstract Article PDF–2.0M

Select item 109038742.

Implications of MTHFD2 expression in renal cell carcinoma aggressiveness

Rafaela V. N. Silva, Lucas A. Berzotti, Marcella G. Laia, Liliane S. Araújo, Crislaine A. Silva, Karen B. Ribeiro, Millena Brandão, Adilha M. R. Michelleti, Juliana R. Machado, Régia C. P. Lira

PLoS One. 2024; 19(2): e0299353. Published online 2024 Feb 29. doi: 10.1371/journal.pone.0299353

PMCID:: PMC10903874

Abstract Article PDF–1.6M

Select item 88854173.

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C. Green, Karl S. A. Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E. Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R. Scaletti, Christoffer Bengtsson, Cynthia B. J. Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L. Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E. Krokan, Per I. Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert J. Homan, Thomas Helleday

Nat Cancer. 2022; 3(2): 156–172. Published online 2022 Feb 28. doi: 10.1038/s43018-022-00331-y

PMCID:: PMC8885417

Abstract Article PDF–13M

Select item 88272884.

Up-regulation of MTHFD2 is associated with clinicopathological characteristics and poor survival in ovarian cancer, possibly by regulating MOB1A signaling

Xiangrong Cui, Huancheng Su, Jiaolin Yang, Xueqing Wu, Kai Huo, Xuan Jing, Sanyuan Zhang

J Ovarian Res. 2022; 15: 23. Published online 2022 Feb 8. doi: 10.1186/s13048-022-00954-w

PMCID:: PMC8827288

Abstract Article PDF–2.9M

Select item 84870425.

MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway

Qiutong Li, Fang Yang, Xiu Shi, Shimin Bian, Fangrong Shen, Yuhong Wu, Chenjie Zhu, Fengqing Fu, Juan Wang, Jinhua Zhou, Youguo Chen

FEBS Open Bio. 2021 Oct; 11(10): 2845–2857. Published online 2021 Sep 18. doi: 10.1002/2211-5463.13249

PMCID:: PMC8487042

Abstract Article PDF–5.2M

Select item 82780976.

MTHFD2 promotes tumorigenesis and metastasis in lung adenocarcinoma by regulating AKT/GSK‐3β/β‐catenin signalling

Yangfeng Shi, Yiming Xu, Jianchang Yao, Chao Yan, Hua Su, Xue Zhang, Enguo Chen, Kejing Ying

J Cell Mol Med. 2021 Jul; 25(14): 7013–7027. Published online 2021 Jun 13. doi: 10.1111/jcmm.16715

PMCID:: PMC8278097

Abstract Article PDF–3.6M

Select item 80400697.

MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma

Nathanael H. Green, Daniel L. Galvan, Shawn S. Badal, Benny H. Chang, Valerie S. LeBleu, Jianyin Long, Eric Jonasch, Farhad R. Danesh

Oncogene. Author manuscript; available in PMC 2021 Apr 12.

Published in final edited form as: Oncogene. 2019 Aug; 38(34): 6211–6225. Published online 2019 Jul 9. doi: 10.1038/s41388-019-0869-4

PMCID:: PMC8040069

Abstract Article PDF–2.1M

Select item 78145868.

Glioma cells require one-carbon metabolism to survive glutamine starvation

Kazuhiro Tanaka, Takashi Sasayama, Hiroaki Nagashima, Yasuhiro Irino, Masatomo Takahashi, Yoshihiro Izumi, Takiko Uno, Naoko Satoh, Akane Kitta, Katsusuke Kyotani, Yuichi Fujita, Mitsuru Hashiguchi, Tomoaki Nakai, Masaaki Kohta, Yoichi Uozumi, Masakazu Shinohara, Kohkichi Hosoda, Takeshi Bamba, Eiji Kohmura

Acta Neuropathol Commun. 2021; 9: 16. Published online 2021 Jan 19. doi: 10.1186/s40478-020-01114-1

PMCID:: PMC7814586

Abstract Article PDF–3.0M

Select item 74897269.

Identification of MTHFD2 as a novel prognosis biomarker in esophageal carcinoma patients based on transcriptomic data and methylation profiling

Jianlin Wang, Judong Luo, Zhiqiang Sun, Fei Sun, Ze Kong, Jingping Yu

Medicine (Baltimore) 2020 Sep 11; 99(37): e22194. Published online 2020 Sep 11. doi: 10.1097/MD.0000000000022194

PMCID:: PMC7489726

Abstract Article PDF–1.1M

Select item 705519510.

High Expression of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Esophageal Squamous Cell Carcinoma and its Clinical Prognostic Significance

Huan He, Peng-Cheng Li, Wei Jia, Bing Hu, Chu-Shu Ji

Med Sci Monit. 2020; 26: e920259-1–e920259-10. Prepublished online 2020 Jan 22. Published online 2020 Feb 23. doi: 10.12659/MSM.920259

PMCID:: PMC7055195

Abstract Article PDF–4.0M

Select item 699168711.

Down‐regulation of MTHFD2 inhibits NSCLC progression by suppressing cycle‐related genes

Chang Yu, Lehe Yang, Mengsi Cai, Feng Zhou, Sisi Xiao, Yaozhe Li, Tingting Wan, Dezhi Cheng, Liangxing Wang, Chengguang Zhao, Xiaoying Huang

J Cell Mol Med. 2020 Jan; 24(2): 1568–1577. Published online 2019 Nov 28. doi: 10.1111/jcmm.14844

PMCID:: PMC6991687

Abstract Article PDF–1.5M

Select item 648476912.

Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2

Tatsunori Nishimura, Asuka Nakata, Xiaoxi Chen, Kurumi Nishi, Makiko Meguro-Horike, Soichiro Sasaki, Kenji Kita, Shin-ichi Horike, Kaori Saitoh, Keiko Kato, Kaori Igarashi, Takahiko Murayama, Susumu Kohno, Chiaki Takahashi, Naofumi Mukaida, Seiji Yano, Tomoyoshi Soga, Arinobu Tojo, Noriko Gotoh

Oncogene. 2019; 38(14): 2464–2481. Published online 2018 Dec 7. doi: 10.1038/s41388-018-0589-1

PMCID:: PMC6484769

Abstract Article PDF–3.4M

Select item 492501813.

Targeting MTHFD2 in acute myeloid leukemia

Yana Pikman, Alexandre Puissant, Gabriela Alexe, Andrew Furman, Liying M. Chen, Stacey M. Frumm, Linda Ross, Nina Fenouille, Christopher F. Bassil, Caroline A. Lewis, Azucena Ramos, Joshua Gould, Richard M. Stone, Daniel J. DeAngelo, Ilene Galinsky, Clary B. Clish, Andrew L. Kung, Michael T. Hemann, Matthew G. Vander Heiden, Versha Banerji, Kimberly Stegmaier

J Exp Med. 2016 Jun 27; 213(7): 1285–1306. doi: 10.1084/jem.20151574

PMCID:: PMC4925018

Abstract Article PDF–3.6M

Select item 460223614.

The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation

Nina Gustafsson Sheppard, Lisa Jarl, Diana Mahadessian, Laura Strittmatter, Angelika Schmidt, Nikhil Madhusudan, Jesper Tegnér, Emma K. Lundberg, Anna Asplund, Mohit Jain, Roland Nilsson

Sci Rep. 2015; 5: 15029. Published online 2015 Oct 13. doi: 10.1038/srep15029

PMCID:: PMC4602236

Abstract Article PDF–1.6M

Select item 410636215.

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

Roland Nilsson, Mohit Jain, Nikhil Madhusudhan, Nina Gustafsson Sheppard, Laura Strittmatter, Caroline Kampf, Jenny Huang, Anna Asplund, Vamsi K Mootha

Nat Commun. Author manuscript; available in PMC 2014 Jul 22.

Published in final edited form as: Nat Commun. 2014; 5: 3128. doi: 10.1038/ncomms4128