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Select item 96320861.

Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer

Rebecca M. Borneman, Elaine Gavin, Alla Musiyenko, Wito Richter, Kevin J. Lee, David K. Crossman, Joel F. Andrews, Annelise M. Wilhite, Steven McClellan, Ileana Aragon, Antonio B. Ward, Xi Chen, Adam B. Keeton, Kristy Berry, Gary A. Piazza, Jennifer M. Scalici, Luciana Madeira da Silva

J Ovarian Res. 2022; 15: 120. Published online 2022 Nov 2. doi: 10.1186/s13048-022-01050-9

PMCID:: PMC9632086

Abstract Article PDF–8.2M

Select item 69553012.

Gonzalo S. Tejeda, Ellanor L. Whiteley, Tarek Z. Deeb, Roland W. Bürli, Stephen J. Moss, Eamonn Sheridan, Nicholas J. Brandon, George S. Baillie

Proc Natl Acad Sci U S A. 2020 Jan 7; 117(1): 677–688. Published online 2019 Dec 23. doi: 10.1073/pnas.1916398117

PMCID:: PMC6955301

Abstract Article PDF–2.4M

Select item 67116573.

Phosphodiesterase 10A IgG: A novel biomarker of paraneoplastic neurologic autoimmunity

Anastasia Zekeridou, Thomas Kryzer, Yong Guo, Anhar Hassan, Vanda Lennon, Claudia F. Lucchinetti, Sean Pittock, Andrew McKeon

Neurology. 2019 Aug 20; 93(8): e815–e822. doi: 10.1212/WNL.0000000000007971

PMCID:: PMC6711657

Abstract Article PDF–856K

Select item 52153094.

Characterization of [¹¹C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain

Kai-Chun Yang, Vladimir Stepanov, Nahid Amini, Stefan Martinsson, Akihiro Takano, Jacob Nielsen, Christoffer Bundgaard, Benny Bang-Andersen, Sarah Grimwood, Christer Halldin, Lars Farde, Sjoerd J. Finnema

Eur J Nucl Med Mol Imaging. 2017; 44(2): 308–320. Published online 2016 Nov 5. doi: 10.1007/s00259-016-3544-9

PMCID:: PMC5215309

Abstract Article PDF–736K

Select item 49312925.

A novel thermoregulatory role for PDE10A in mouse and human adipocytes

Mohammed K Hankir, Mathias Kranz, Thorsten Gnad, Juliane Weiner, Sally Wagner, Winnie Deuther‐Conrad, Felix Bronisch, Karen Steinhoff, Julia Luthardt, Nora Klöting, Swen Hesse, John P Seibyl, Osama Sabri, John T Heiker, Matthias Blüher, Alexander Pfeifer, Peter Brust, Wiebke K Fenske

EMBO Mol Med. 2016 Jul; 8(7): 796–812. Published online 2016 May 31. doi: 10.15252/emmm.201506085

PMCID:: PMC4931292

Abstract Article PDF–1.4M

Select item 48724336.

Novel, primate-specific PDE10A isoform highlights gene expression complexity in human striatum with implications on the molecular pathology of bipolar disorder

C M MacMullen, K Vick, R Pacifico, M Fallahi-Sichani, R L Davis

Transl Psychiatry. 2016 Feb; 6(2): e742. Published online 2016 Feb 23. doi: 10.1038/tp.2016.3

PMCID:: PMC4872433

Abstract Article PDF–1.0M

Select item 48332917.

De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions

Niccolò E. Mencacci, Erik-Jan Kamsteeg, Kosuke Nakashima, Lea R’Bibo, David S. Lynch, Bettina Balint, Michèl A.A.P. Willemsen, Matthew E. Adams, Sarah Wiethoff, Kazunori Suzuki, Ceri H. Davies, Joanne Ng, Esther Meyer, Liana Veneziano, Paola Giunti, Deborah Hughes, F. Lucy Raymond, Miryam Carecchio, Giovanna Zorzi, Nardo Nardocci, Chiara Barzaghi, Barbara Garavaglia, Vincenzo Salpietro, John Hardy, Alan M. Pittman, Henry Houlden, Manju A. Kurian, Haruhide Kimura, Lisenka E.L.M. Vissers, Nicholas W. Wood, Kailash P. Bhatia

Am J Hum Genet. 2016 Apr 7; 98(4): 763–771. Published online 2016 Apr 7. doi: 10.1016/j.ajhg.2016.02.015

PMCID:: PMC4833291

Abstract Article PDF–1.2M

Select item 98904768.

Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling

Lingfeng Luo, Yujun Cai, Yishuai Zhang, Chia G Hsu, Vyacheslav A Korshunov, Xiaochun Long, Peter A Knight, Bradford C Berk, Chen Yan

Cardiovasc Res. 2022 Aug; 118(12): 2703–2717. Published online 2021 Sep 22. doi: 10.1093/cvr/cvab304

Correction in:: Cardiovasc Res. 2023 Mar; 119(3): 879.

PMCID:: PMC9890476

Abstract Article PDF–2.0M

Select item 71539829.

Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease

Reagan Farmer, Steven D. Burbano, Neema S. Patel, Angelo Sarmiento, Abigail J. Smith, Michy P. Kelly

Cell Signal. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: Cell Signal. 2020 Jun; 70: 109592. Published online 2020 Feb 29. doi: 10.1016/j.cellsig.2020.109592

PMCID:: PMC7153982

Abstract Article PDF–2.6M

Select item 663248510.

Interplay of Palmitoylation and Phosphorylation in the Trafficking and Localization of Phosphodiesterase 10A: Implications for the Treatment of Schizophrenia

Erik I. Charych, Li-Xin Jiang, Frederick Lo, Kelly Sullivan, Nicholas J. Brandon

J Neurosci. 2010 Jul 7; 30(27): 9027–9037. doi: 10.1523/JNEUROSCI.1635-10.2010

PMCID:: PMC6632485

Abstract Article PDF–1.9M

Select item 469499811.

Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10

Nan Li, Xi Chen, Bing Zhu, Verónica Ramírez-Alcántara, Joshua C. Canzoneri, Kevin Lee, Sara Sigler, Bernard Gary, Yonghe Li, Wei Zhang, Mary P. Moyer, E. Alan Salter, Andrzej Wierzbicki, Adam B. Keeton, Gary A. Piazza

Oncotarget. 2015 Sep 29; 6(29): 27403–27415. Published online 2015 Jul 25. doi: 10.18632/oncotarget.4741

PMCID:: PMC4694998

Abstract Article PDF–2.8M

Select item 421201912.

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and ß-catenin-dependent TCF transcriptional activity

Nan Li, Kevin Lee, Yaguang Xi, Bing Zhu, Bernard D. Gary, Verónica Ramírez-Alcántara, Evrim Gurpinar, Joshua C. Canzoneri, Alexandra Fajardo, Sara Sigler, John T. Piazza, Xi Chen, Joel Andrews, Meagan Thomas, Wenyan Lu, Yonghe Li, Danuel J. Laan, Mary P. Moyer, Suzanne Russo, Brian T. Eberhardt, Larry Yet, Adam B. Keeton, William E. Grizzle, Gary A. Piazza

Oncogene. Author manuscript; available in PMC 2015 Sep 19.

Published in final edited form as: Oncogene. 2015 Mar 19; 34(12): 1499–1509. Published online 2014 Apr 7. doi: 10.1038/onc.2014.94

PMCID:: PMC4212019

Abstract Article PDF–2.1M

Select item 365395113.

HPRT-Deficiency Dysregulates cAMP-PKA Signaling and Phosphodiesterase 10A Expression: Mechanistic Insight and Potential Target for Lesch-Nyhan Disease?

Ghiabe-Henri Guibinga, Fiona Murray, Nikki Barron

PLoS One. 2013; 8(5): e63333. Published online 2013 May 14. doi: 10.1371/journal.pone.0063333

PMCID:: PMC3653951

Abstract Article PDF–962K

Select item 307392914.

Phosphodiesterase 10A Upregulation Contributes to Pulmonary Vascular Remodeling

Xia Tian, Christina Vroom, Hossein Ardeschir Ghofrani, Norbert Weissmann, Ewa Bieniek, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly, Soni Savai Pullamsetti

PLoS One. 2011; 6(4): e18136. Published online 2011 Apr 11. doi: 10.1371/journal.pone.0018136

PMCID:: PMC3073929

Abstract Article PDF–706K

Select item 483343615.

Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy

Christine P. Diggle, Stacey J. Sukoff Rizzo, Michael Popiolek, Reetta Hinttala, Jan-Philip Schülke, Manju A. Kurian, Ian M. Carr, Alexander F. Markham, David T. Bonthron, Christopher Watson, Saghira Malik Sharif, Veronica Reinhart, Larry C. James, Michelle A. Vanase-Frawley, Erik Charych, Melanie Allen, John Harms, Christopher J. Schmidt, Joanne Ng, Karen Pysden, Christine Strick, Päivi Vieira, Katariina Mankinen, Hannaleena Kokkonen, Matti Kallioinen, Raija Sormunen, Juha O. Rinne, Jarkko Johansson, Kati Alakurtti, Laura Huilaja, Tiina Hurskainen, Kaisa Tasanen, Eija Anttila, Tiago Reis Marques, Oliver Howes, Marius Politis, Somayyeh Fahiminiya, Khanh Q. Nguyen, Jacek Majewski, Johanna Uusimaa, Eamonn Sheridan, Nicholas J. Brandon

Am J Hum Genet. 2016 Apr 7; 98(4): 735–743. Published online 2016 Apr 7. doi: 10.1016/j.ajhg.2016.03.015

PMCID:: PMC4833436

Abstract Article PDF–654K

Select item 289324216.

Common variants in FOXP1 are associated with generalized vitiligo

Ying Jin, Stanca A. Birlea, Pamela R. Fain, Christina M. Mailloux, Sheri L. Riccardi, Katherine Gowan, Paulene J. Holland, Dorothy C. Bennett, Margaret R. Wallace, Wayne T. McCormack, E. Helen Kemp, David J. Gawkrodger, Anthony P. Weetman, Mauro Picardo, Giovanni Leone, Alain Taïeb, Thomas Jouary, Khaled Ezzedine, Nanny van Geel, Jo Lambert, Andreas Overbeck, Richard A. Spritz

Nat Genet. Author manuscript; available in PMC 2011 Jan 1.

Published in final edited form as: Nat Genet. 2010 Jul; 42(7): 576–578. Published online 2010 Jun 6. doi: 10.1038/ng.602

PMCID:: PMC2893242

Abstract Article PDF–1.4M

Select item 376042017.

Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate

Alexis C. Frazier-Wood, Stella Aslibekyan, Ingrid B. Borecki, Paul N. Hopkins, Chao-Qiang Lai, Jose M. Ordovas, Robert J. Straka, Hemant K. Tiwari, Donna K. Arnett

Pharmacogenet Genomics. Author manuscript; available in PMC 2013 Oct 1.

Published in final edited form as: Pharmacogenet Genomics. 2012 Oct; 22(10): 750–757. doi: 10.1097/FPC.0b013e328357f6af

PMCID:: PMC3760420

Abstract Article PDF–723K

Select item 242726718.

Phosphodiesterase 8B Gene Variants Are Associated with Serum TSH Levels and Thyroid Function

Lisette Arnaud-Lopez, Gianluca Usala, Graziano Ceresini, Braxton D. Mitchell, Maria Grazia Pilia, Maria Grazia Piras, Natascia Sestu, Andrea Maschio, Fabio Busonero, Giuseppe Albai, Mariano Dei, Sandra Lai, Antonella Mulas, Laura Crisponi, Toshiko Tanaka, Stefania Bandinelli, Jack M. Guralnik, Angela Loi, Lenuta Balaci, Gabriella Sole, Alessia Prinzis, Stefano Mariotti, Alan R. Shuldiner, Antonio Cao, David Schlessinger, Manuela Uda, Gonçalo R. Abecasis, Ramaiah Nagaraja, Serena Sanna, Silvia Naitza

Am J Hum Genet. 2008 Jun 6; 82(6): 1270–1280. Published online 2008 May 30. doi: 10.1016/j.ajhg.2008.04.019

PMCID:: PMC2427267

Abstract Article PDF–920K

Select item 358083519.

Genome-wide association study of conduct disorder symptomatology

DM Dick, F Aliev, RF Krueger, A Edwards, A Agrawal, M Lynskey, P Lin, M Schuckit, V Hesselbrock, J Nurnberger, Jr, L Almasy, B Porjesz, HJ Edenberg, K Bucholz, J Kramer, S Kuperman, L Bierut

Mol Psychiatry. Author manuscript; available in PMC 2013 Feb 25.

Published in final edited form as: Mol Psychiatry. 2011 Aug; 16(8): 800–808. Published online 2010 Jun 29. doi: 10.1038/mp.2010.73

PMCID:: PMC3580835

Abstract Article PDF–684K

Select item 356717520.

A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function

Eleonora Porcu, Marco Medici, Giorgio Pistis, Claudia B. Volpato, Scott G. Wilson, Anne R. Cappola, Steffan D. Bos, Joris Deelen, Martin den Heijer, Rachel M. Freathy, Jari Lahti, Chunyu Liu, Lorna M. Lopez, Ilja M. Nolte, Jeffrey R. O'Connell, Toshiko Tanaka, Stella Trompet, Alice Arnold, Stefania Bandinelli, Marian Beekman, Stefan Böhringer, Suzanne J. Brown, Brendan M. Buckley, Clara Camaschella, Anton J. M. de Craen, Gail Davies, Marieke C. H. de Visser, Ian Ford, Tom Forsen, Timothy M. Frayling, Laura Fugazzola, Martin Gögele, Andrew T. Hattersley, Ad R. Hermus, Albert Hofman, Jeanine J. Houwing-Duistermaat, Richard A. Jensen, Eero Kajantie, Margreet Kloppenburg, Ee M. Lim, Corrado Masciullo, Stefano Mariotti, Cosetta Minelli, Braxton D. Mitchell, Ramaiah Nagaraja, Romana T. Netea-Maier, Aarno Palotie, Luca Persani, Maria G. Piras, Bruce M. Psaty, Katri Räikkönen, J. Brent Richards, Fernando Rivadeneira, Cinzia Sala, Mona M. Sabra, Naveed Sattar, Beverley M. Shields, Nicole Soranzo, John M. Starr, David J. Stott, Fred C. G. J. Sweep, Gianluca Usala, Melanie M. van der Klauw, Diana van Heemst, Alies van Mullem, Sita H.Vermeulen, W. Edward Visser, John P. Walsh, Rudi G. J. Westendorp, Elisabeth Widen, Guangju Zhai, Francesco Cucca, Ian J. Deary, Johan G. Eriksson, Luigi Ferrucci, Caroline S. Fox, J. Wouter Jukema, Lambertus A. Kiemeney, Peter P. Pramstaller, David Schlessinger, Alan R. Shuldiner, Eline P. Slagboom, André G. Uitterlinden, Bijay Vaidya, Theo J. Visser, Bruce H. R. Wolffenbuttel, Ingrid Meulenbelt, Jerome I. Rotter, Tim D. Spector, Andrew A. Hicks, Daniela Toniolo, Serena Sanna, Robin P. Peeters, Silvia Naitza

PLoS Genet. 2013 Feb; 9(2): e1003266. Published online 2013 Feb 7. doi: 10.1371/journal.pgen.1003266

PMCID:: PMC3567175

Abstract Article PDF–1.6M

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