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Select item 107474751.

The Ca²⁺ channel ORAI1 is a regulator of oral cancer growth and nociceptive pain

Ga-Yeon Son, Nguyen Huu Tu, Maria Daniela Santi, Santiago Loya Lopez, Guilherme H. Souza Bomfim, Manikandan Vinu, Fang Zhou, Ariya Chaloemtoem, Rama Alhariri, Youssef Idaghdour, Rajesh Khanna, Yi Ye, Rodrigo S. Lacruz

Sci Signal. Author manuscript; available in PMC 2023 Dec 23.

Published in final edited form as: Sci Signal. 2023 Sep 5; 16(801): eadf9535. Published online 2023 Sep 5. doi: 10.1126/scisignal.adf9535

PMCID:: PMC10747475

Article PDF–2.0M

Select item 104850212.

Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels

Michaela M. Novakovic, Kirill S. Korshunov, Rogan A. Grant, Megan E. Martin, Hiam A. Valencia, G. R. Scott Budinger, Jelena Radulovic, Murali Prakriya

Nat Commun. 2023; 14: 5500. Published online 2023 Sep 7. doi: 10.1038/s41467-023-40968-6

PMCID:: PMC10485021

Article PDF–4.0M

Select item 96000983.

Reduction in SOCE and Associated Aggregation in Platelets from Mice with Platelet-Specific Deletion of Orai1

Linlin Yang, Roger Ottenheijm, Paul Worley, Marc Freichel, Juan E. Camacho Londoño

Cells. 2022 Oct; 11(20): 3225. Published online 2022 Oct 14. doi: 10.3390/cells11203225

PMCID:: PMC9600098

Article PDF–2.5M

Select item 93658744.

Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy

Maricela García-Castañeda, Antonio Michelucci, Nan Zhao, Sundeep Malik, Robert T. Dirksen

J Gen Physiol. 2022 Sep 5; 154(9): e202213081. Published online 2022 Aug 8. doi: 10.1085/jgp.202213081

PMCID:: PMC9365874

Article PDF–5.0M

Select item 92666585.

Silencing of the Ca²⁺ Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice

Roberto Silva-Rojas, Laura Pérez-Guàrdia, Emma Lafabrie, David Moulaert, Jocelyn Laporte, Johann Böhm

Int J Mol Sci. 2022 Jul; 23(13): 6968. Published online 2022 Jun 23. doi: 10.3390/ijms23136968

PMCID:: PMC9266658

Article PDF–2.9M

Select item 89964796.

Orai1 downregulation causes proliferation reduction and cell cycle arrest via inactivation of the Ras-NF-κB signaling pathway in osteoblasts

Yunshan Guo, Jinzhu Fan, Shuguang Liu, Dingjun Hao

BMC Musculoskelet Disord. 2022; 23: 347. Published online 2022 Apr 11. doi: 10.1186/s12891-022-05311-y

PMCID:: PMC8996479

Article PDF–2.9M

Select item 89169827.

Ca²⁺ signaling augmented by ORAI1 trafficking regulates the pathogenic state of effector T cells

Beibei Wu, Jin Seok Woo, Zuoming Sun, Sonal Srikanth, Yousang Gwack

J Immunol. Author manuscript; available in PMC 2023 Mar 15.

Published in final edited form as: J Immunol. 2022 Mar 15; 208(6): 1329–1340. Published online 2022 Feb 25. doi: 10.4049/jimmunol.2100871

PMCID:: PMC8916982

Article PDF–2.3M

Select item 87418828.

Orai1 is a crucial downstream partner of group I metabotropic glutamate receptor signaling in dorsal horn neurons

Jingsheng Xia, Yannong Dou, Yixiao Mei, Frances M. Munoz, Ruby Gao, Xinghua Gao, Daling Li, Patrick Osei-Owusu, James Schiffenhaus, Alex Bekker, Yuan-Xiang Tao, Huijuan Hu

Pain. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: Pain. 2022 Apr 1; 163(4): 652–664. doi: 10.1097/j.pain.0000000000002396

PMCID:: PMC8741882

Article PDF–2.8M

Select item 69705499.

Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca²⁺ Handling After Pressure Overload

Fiona Bartoli, Marc A. Bailey, Baptiste Rode, Philippe Mateo, Fabrice Antigny, Kaveen Bedouet, Pascale Gerbaud, Rajendra Gosain, Jeffrey Plante, Katherine Norman, Susana Gomez, Florence Lefebvre, Catherine Rucker-Martin, Justin F.X. Ainscough, Mark T. Kearney, Alexander-Francisco Bruns, Jian Shi, Hollie L. Appleby, Richard S. Young, Heba M. Shawer, Marjolaine Debant, Ana-Maria Gomez, David J. Beech, Richard Foster, Jean-Pierre Benitah, Jessica Sabourin

Circulation. 2020 Jan 21; 141(3): 199–216. Published online 2020 Jan 7. doi: 10.1161/CIRCULATIONAHA.118.038891

PMCID:: PMC6970549

Article PDF–4.7M

Select item 688801010.

Changes in Calcium Homeostasis and Gene Expression Implicated in Epilepsy in Hippocampi of Mice Overexpressing ORAI1

Lukasz Majewski, Bartosz Wojtas, Filip Maciąg, Jacek Kuznicki

Int J Mol Sci. 2019 Nov; 20(22): 5539. Published online 2019 Nov 6. doi: 10.3390/ijms20225539

PMCID:: PMC6888010

Article PDF–1.4M

Select item 683784611.

Transverse tubule remodeling enhances Orai1-dependent Ca²⁺ entry in skeletal muscle

Antonio Michelucci, Simona Boncompagni, Laura Pietrangelo, Maricela García-Castañeda, Takahiro Takano, Sundeep Malik, Robert T Dirksen, Feliciano Protasi

eLife. 2019; 8: e47576. Published online 2019 Oct 28. doi: 10.7554/eLife.47576

PMCID:: PMC6837846

Article PDF–5.0M

Select item 578396712.

Orai1 Plays a Crucial Role in Central Sensitization by Modulating Neuronal Excitability

Yannong Dou, Jingsheng Xia, Ruby Gao, Xinghua Gao, Frances M. Munoz, Dongyu Wei, Yuzhen Tian, James E. Barrett, Seena Ajit, Olimpia Meucci, James W. Putney, Jr, Yue Dai, Huijuan Hu

J Neurosci. 2018 Jan 24; 38(4): 887–900. doi: 10.1523/JNEUROSCI.3007-17.2017

PMCID:: PMC5783967

Article PDF–4.0M

Select item 555528913.

Evidence that Orai1 does not contribute to store-operated TRPC1 channels in vascular smooth muscle cells

Jian Shi, Francesc Miralles, Jean-Pierre Kinet, Lutz Birnbaumer, William A. Large, Anthony P. Albert

Channels (Austin) 2017; 11(4): 329–339. Published online 2017 Mar 16. doi: 10.1080/19336950.2017.1303025

PMCID:: PMC5555289

Article PDF–916K

Select item 544066814.

Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment

Kyun-Do Kim, Seyeon Bae, Tara Capece, Hristina Nedelkovska, Rafael G. de Rubio, Alan V. Smrcka, Chang-Duk Jun, Woojin Jung, Byeonghak Park, Tae-il Kim, Minsoo Kim

Nat Commun. 2017; 8: 15365. Published online 2017 May 15. doi: 10.1038/ncomms15365

PMCID:: PMC5440668

Article PDF–1.4M

Select item 534569315.

Orai1-mediated antimicrobial secretion from pancreatic acini shapes the gut microbiome and regulates gut innate immunity

Malini Ahuja, Daniella M Schwartz, Mayank Tandon, Aran Son, Mei Zeng, William Swaim, Michael Eckhaus, Victoria Hoffman, Yiyuan Cui, Bo Xiao, Paul F Worley, Shmuel Muallem

Cell Metab. Author manuscript; available in PMC 2018 Mar 7.

Published in final edited form as: Cell Metab. 2017 Mar 7; 25(3): 635–646. doi: 10.1016/j.cmet.2017.02.007

PMCID:: PMC5345693

Article PDF–2.5M

Select item 510211316.

Orai1 enhances muscle endurance by promoting fatigue-resistant type I fiber content but not through acute store-operated Ca²⁺ entry

Ellie M. Carrell, Aundrea R. Coppola, Helen J. McBride, Robert T. Dirksen

FASEB J. 2016 Dec; 30(12): 4109–4119. Published online 2016 Sep 1. doi: 10.1096/fj.201600621R

PMCID:: PMC5102113

Article

Select item 484486617.

Male infertility in mice lacking the store-operated Ca²⁺ channel Orai1

Felicity M. Davis, Eugenia H. Goulding, Diane M. D’Agostin, Kyathanahalli S. Janardhan, Connie A. Cummings, Gary S. Bird, Edward M. Eddy, James W. Putney

Cell Calcium. Author manuscript; available in PMC 2017 Apr 1.

Published in final edited form as: Cell Calcium. 2016 Apr; 59(4): 189–197. Published online 2016 Feb 27. doi: 10.1016/j.ceca.2016.02.007

PMCID:: PMC4844866

Article PDF–3.8M

Select item 442647318.

Essential role of Orai1 store-operated calcium channels in lactation

Felicity M. Davis, Agnes Janoshazi, Kyathanahalli S. Janardhan, Natacha Steinckwich, Diane M. D’Agostin, John G. Petranka, Pooja N. Desai, Sarah J. Roberts-Thomson, Gary S. Bird, Deirdre K. Tucker, Suzanne E. Fenton, Stefan Feske, Gregory R. Monteith, James W. Putney, Jr.

Proc Natl Acad Sci U S A. 2015 May 5; 112(18): 5827–5832. Published online 2015 Apr 20. doi: 10.1073/pnas.1502264112

PMCID:: PMC4426473

Article PDF–1.5M

Select item 404834119.

The calcium release-activated calcium channel Orai1 represents a crucial component in hypertrophic compensation and the development of dilated cardiomyopathy

Jaime S Horton, Cadie L Buckley, Ernest M Alvarez, Anita Schorlemmer, Alexander J Stokes

Channels (Austin) 2014 Jan 1; 8(1): 35–43. Published online 2013 Oct 17. doi: 10.4161/chan.26581

PMCID:: PMC4048341

Article PDF–7.6M

Select item 394855620.

Role of Orai1 and store-operated calcium entry in mouse lacrimal gland signalling and function

Juan Xing, John G Petranka, Felicity M Davis, Pooja N Desai, James W Putney, Gary S Bird

J Physiol. 2014 Mar 1; 592(Pt 5): 927–939. Published online 2014 Jan 6. doi: 10.1113/jphysiol.2013.267740

PMCID:: PMC3948556

Article PDF–1.0M

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