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Select item 107867231.

Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids

Hélène Lasolle, Andrea Schiavo, Adrien Tourneur, Pierre Gillotay, Bárbara de Faria da Fonseca, Lucieli Ceolin, Olivier Monestier, Benilda Aganahi, Laura Chomette, Marina Malta Letro Kizys, Lieven Haenebalcke, Tim Pieters, Steven Goossens, Jody Haigh, Vincent Detours, Ana Luiza Silva Maia, Sabine Costagliola, Mírian Romitti

Oncogene. 2024; 43(3): 155–170. Published online 2023 Nov 20. doi: 10.1038/s41388-023-02889-y

PMCID:: PMC10786723

Abstract Article PDF–14M

Select item 105857502.

BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8⁺ T cell infiltration in colorectal cancer

Wenjing Li, Chenyi Zhao, Wenhui Li, Yang Gong, Kaili Ma, Yujie Lu, Xiaowei Liu, Lianjun Zhang, Feng Guo

J Transl Med. 2023; 21: 737. Published online 2023 Oct 18. doi: 10.1186/s12967-023-04606-5

PMCID:: PMC10585750

Abstract Article PDF–16M

Select item 105143323.

BRAF^V600E-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism

Paulina Rzasa, Sarah Whelan, Pooyeh Farahmand, Hong Cai, Inna Guterman, Raquel Palacios-Gallego, Shanthi S. Undru, Lauren Sandford, Caleb Green, Catherine Andreadi, Maria Mintseva, Emma Parrott, Hong Jin, Fiona Hey, Susan Giblett, Nicolas B. Sylvius, Natalie S. Allcock, Anna Straatman-Iwanowska, Roberto Feuda, Cristina Tufarelli, Karen Brown, Catrin Pritchard, Alessandro Rufini

Commun Biol. 2023; 6: 962. Published online 2023 Sep 21. doi: 10.1038/s42003-023-05331-x

PMCID:: PMC10514332

Abstract Article PDF–4.5M

Select item 98734974.

Central role for BRAF in cardiac hypertrophy: rethinking the pathological–physiological divide

Raffaele Altara, George W. Booz

Clin Sci (Lond) 2023 Jan; 137(2): 143–148. Published online 2023 Jan 18. doi: 10.1042/CS20220776

PMCID:: PMC9873497

Abstract Article PDF–540K

Select item 98403625.

S-adenosylmethionine blocks tumorigenesis and with immune checkpoint inhibitor enhances anti-cancer efficacy against BRAF mutant and wildtype melanomas

A. Mehdi, M. Attias, A. Arakelian, M. Szyf, C.A. Piccirillo, S.A. Rabbani

Neoplasia. 2023 Feb; 36: 100874. Published online 2023 Jan 11. doi: 10.1016/j.neo.2022.100874

PMCID:: PMC9840362

Abstract Article PDF–4.3M

Select item 96793676.

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

Hajed O. Alharbi, Michelle A. Hardyman, Joshua J. Cull, Thomais Markou, Susanna T.E. Cooper, Peter E. Glennon, Stephen J. Fuller, Peter H. Sugden, Angela Clerk

Clin Sci (Lond) 2022 Nov; 136(22): 1661–1681. Published online 2022 Nov 21. doi: 10.1042/CS20220607

PMCID:: PMC9679367

Abstract Article PDF–7.7M

Select item 80202657.

Overcoming T-cell exhaustion in LCH: PD-1 blockade and targeted MAPK inhibition are synergistic in a mouse model of LCH

Amel Sengal, Jessica Velazquez, Meryl Hahne, Thomas M. Burke, Harshal Abhyankar, Robert Reyes, Walter Olea, Brooks Scull, Olive S. Eckstein, Camille Bigenwald, Catherine M. Bollard, Wendong Yu, Miriam Merad, Kenneth L. McClain, Carl E. Allen, Rikhia Chakraborty

Blood. 2021 Apr 1; 137(13): 1777–1791. Prepublished online 2020 Oct 19. doi: 10.1182/blood.2020005867

PMCID:: PMC8020265

Abstract Article

Select item 79197298.

Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease

Eriene-Heidi Sidhom, Choah Kim, Maria Kost-Alimova, May Theng Ting, Keith Keller, Julian Avila-Pacheco, Andrew J.B. Watts, Katherine A. Vernon, Jamie L. Marshall, Estefanía Reyes-Bricio, Matthew Racette, Nicolas Wieder, Giulio Kleiner, Elizabeth J. Grinkevich, Fei Chen, Astrid Weins, Clary B. Clish, Jillian L. Shaw, Catarina M. Quinzii, Anna Greka

J Clin Invest. 2021 Mar 1; 131(5): e141380. Published online 2021 Mar 1. doi: 10.1172/JCI141380

PMCID:: PMC7919729

Abstract Article PDF–2.7M

Select item 75537749.

Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes

Rolando Ruiz-Vega, Chi-Fen Chen, Emaad Razzak, Priya Vasudeva, Tatiana B Krasieva, Jessica Shiu, Michael G Caldwell, Huaming Yan, John Lowengrub, Anand K Ganesan, Arthur D Lander

eLife. 2020; 9: e61026. Published online 2020 Oct 13. doi: 10.7554/eLife.61026

PMCID:: PMC7553774

Abstract Article PDF–3.4M

Select item 710113610.

MAPK mutations and cigarette smoke promote the pathogenesis of pulmonary Langerhans cell histiocytosis

Huan Liu, Andrew R. Osterburg, Jennifer Flury, Zulma Swank, Dennis W. McGraw, Nishant Gupta, Kathryn A. Wikenheiser-Brokamp, Ashish Kumar, Abdellatif Tazi, Yoshikazu Inoue, Masaki Hirose, Francis X. McCormack, Michael T. Borchers

JCI Insight. 2020 Feb 27; 5(4): e132048. Published online 2020 Feb 27. doi: 10.1172/jci.insight.132048

PMCID:: PMC7101136

Abstract Article PDF–7.8M

Select item 701593511.

Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma

Elena Galvani, Piyushkumar A. Mundra, Sara Valpione, Pablo Garcia-Martinez, Matthew Smith, Jonathan Greenall, Rohit Thakur, Beth Helmink, Miles C. Andrews, Louis Boon, Christopher Chester, Gabriela Gremel, Kate Hogan, Amit Mandal, Kang Zeng, Antonia Banyard, Garry Ashton, Martin Cook, Paul Lorigan, Jennifer A. Wargo, Nathalie Dhomen, Richard Marais

Nat Commun. 2020; 11: 853. Published online 2020 Feb 12. doi: 10.1038/s41467-020-14632-2

PMCID:: PMC7015935

Abstract Article PDF–1.0M

Select item 663664212.

Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf^V600E-Induced Tumorigenesis

Yong Tao, Byunghak Kang, Daniel A. Petkovich, Yuba R. Bhandari, Julie In, Genevieve Stein-O’ Brien, Xiangqian Kong, Wenbing Xie, Nicholas Zachos, Shinji Maegawa, Himani Vaidya, Stephen Brown, Ray-Whay Chiu Yen, Xiaojian Shao, Jai Thakor, Zhihao Lu, Yi Cai, Yuezheng Zhang, Izaskun Mallona, Miguel Angel Peinado, Cynthia A. Zahnow, Nita Ahuja, Elana Fertig, Jean-Pierre Issa, Stephen B. Baylin, Hariharan Easwaran

Cancer Cell. Author manuscript; available in PMC 2019 Jul 17.

Published in final edited form as: Cancer Cell. 2019 Feb 11; 35(2): 315–328.e6. doi: 10.1016/j.ccell.2019.01.005

PMCID:: PMC6636642

Abstract Article PDF–1.4M

Select item 631962013.

Oncogenic BRAF^V600E governs regulatory T cell recruitment during melanoma tumorigenesis

Tamer B. Shabaneh, Aleksey K. Molodtsov, Shannon M. Steinberg, Peisheng Zhang, Gretel M. Torres, Gadisti A. Mohamed, Andrea Boni, Tyler J. Curiel, Christina V. Angeles, Mary Jo Turk

Cancer Res. Author manuscript; available in PMC 2019 Sep 1.

Published in final edited form as: Cancer Res. 2018 Sep 1; 78(17): 5038–5049. Published online 2018 Jul 19. doi: 10.1158/0008-5472.CAN-18-0365

PMCID:: PMC6319620

Abstract Article PDF–1.1M

Select item 591914914.

B‐raf Oncogene: Activation by Rearrangements and Assignment to Human Chromosome 7

Takashi Kamiyama, Nobuo Aoki, Yasuhito Yuasa

Jpn J Cancer Res. 1993 Mar; 84(3): 250–256. doi: 10.1111/j.1349-7006.1993.tb02864.x

PMCID:: PMC5919149

Summary PDF–406K

Select item 583698415.

Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia

Catherine E. Bond, Cheng Liu, Futoshi Kawamata, Diane M. McKeone, Winnie Fernando, Saara Jamieson, Sally-Ann Pearson, Alexandra Kane, Susan L. Woods, Tamsin R. M. Lannagan, Roshini Somashekar, Young Lee, Troy Dumenil, Gunter Hartel, Kevin J. Spring, Jennifer Borowsky, Lochlan Fennell, Mark Bettington, Jason Lee, Daniel L. Worthley, Barbara A. Leggett, Vicki L. J. Whitehall

Epigenetics. 2018; 13(1): 40–48. Published online 2018 Feb 19. doi: 10.1080/15592294.2017.1411446

PMCID:: PMC5836984

Abstract Article PDF–1.1M

Select item 581418016.

Activation of Grm1 expression by mutated BRaf (V600E) in vitro and in vivo

Ho-Chung Chen, Jairo Sierra, Lumeng Jenny Yu, Robert Cerchio, Jr., Brian A. Wall, James Goydos, Suzie Chen

Oncotarget. 2018 Jan 19; 9(5): 5861–5875. Published online 2017 Dec 23. doi: 10.18632/oncotarget.23637

PMCID:: PMC5814180

Abstract Article PDF–3.0M

Select item 574884617.

RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions

Brandon Hogstad, Marie-Luise Berres, Rikhia Chakraborty, Jun Tang, Camille Bigenwald, Madhavika Serasinghe, Karen Phaik Har Lim, Howard Lin, Tsz-Kwong Man, Romain Remark, Samantha Baxter, Veronika Kana, Stefan Jordan, Zoi Karoulia, Wing-hong Kwan, Marylene Leboeuf, Elisa Brandt, Helene Salmon, Kenneth McClain, Poulikos Poulikakos, Jerry Chipuk, Willem J.M. Mulder, Carl E. Allen, Miriam Merad

J Exp Med. 2018 Jan 2; 215(1): 319–336. doi: 10.1084/jem.20161881

PMCID:: PMC5748846

Abstract Article PDF–2.3M

Select item 564805618.

A Braf kinase-inactive mutant induces lung adenocarcinoma

Patricia Nieto, Chiara Ambrogio, Laura Esteban-Burgos, Gonzalo Gómez-López, María Teresa Blasco, Zhan Yao, Richard Marais, Neal Rosen, Roberto Chiarle, David g. Pisano, Mariano Barbacid, David Santamaría

Nature. Author manuscript; available in PMC 2018 Feb 10.

Published in final edited form as: Nature. 2017 Aug 10; 548(7666): 239–243. Published online 2017 Aug 2. doi: 10.1038/nature23297

PMCID:: PMC5648056

Abstract Article PDF–4.0M

Select item 522297619.

BRAF Mutations Open Doors for N-Ethyl-N-Nitrosourea–Induced Gliomagenesis

Robert S. McNeill, David M. Irvin, C. Ryan Miller

Am J Pathol. 2016 Oct; 186(10): 2551–2554. doi: 10.1016/j.ajpath.2016.07.005

PMCID:: PMC5222976

Abstract Article PDF–312K

Select item 521409520.

Role of the BrafV637E mutation in hepatocarcinogenesis induced by treatment with diethylnitrosamine in neonatal B6C3F1 mice

Masahiro Yamamoto, Hiroki Tanaka, Bing Xin, Yuji Nishikawa, Kosuke Yamazaki, Keiko Shimizu, Katsuhiro Ogawa

Mol Carcinog. 2017 Feb; 56(2): 478–488. Published online 2016 Jun 10. doi: 10.1002/mc.22510

PMCID:: PMC5214095

Abstract Article PDF–2.3M

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