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Select item 27750081.

Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway

Henri J. Huttunen, Camilla Peach, Raja Bhattacharyya, Cory Barren, Warren Pettingell, Birgit Hutter-Paier, Manfred Windisch, Oksana Berezovska, Dora M. Kovacs

FASEB J. 2009 Nov; 23(11): 3819–3828. doi: 10.1096/fj.09-134999

PMCID:: PMC2775008

Abstract Article

Select item 108232782.

SCD1 inhibition enhances the effector functions of CD8⁺ T cells via ACAT1‐dependent reduction of esterified cholesterol

Toshihiro Sugi, Yuki Katoh, Toshikatsu Ikeda, Daichi Seta, Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Daiki Kato, Kanoko Katoh, Kei Kawana, Tomonori Yaguchi, Yutaka Kawakami, Shuichi Hirai

Cancer Sci. 2024 Jan; 115(1): 48–58. Published online 2023 Oct 25. doi: 10.1111/cas.15999

PMCID:: PMC10823278

Abstract Article PDF–1.4M

Select item 72163713.

Involvement of ABC-transporters and acyltransferase 1 in intracellular cholesterol-mediated autophagy in bovine alveolar macrophages in response to the Bacillus Calmette-Guerin (BCG) infection

Jinrui Xu, Yanbing Zhou, Yi Yang, Cuiping Lv, Xiaoming Liu, Yujiong Wang

BMC Immunol. 2020; 21: 26. Published online 2020 May 12. doi: 10.1186/s12865-020-00356-x

PMCID:: PMC7216371

Abstract Article PDF–1.8M

Select item 69165004.

Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function

Yanqing Xu, Ximing Du, Nigel Turner, Andrew J. Brown, Hongyuan Yang

J Biol Chem. 2019 Dec 13; 294(50): 19306–19321. Published online 2019 Nov 14. doi: 10.1074/jbc.RA119.011160

PMCID:: PMC6916500

Abstract Article PDF–5.8M

Select item 59284255.

In vitro exploration of ACAT contributions to lipid droplet formation during adipogenesis

Yuyan Zhu, Chih-Yu Chen, Junjie Li, Ji-Xin Cheng, Miran Jang, Kee-Hong Kim

J Lipid Res. 2018 May; 59(5): 820–829. Published online 2018 Mar 16. doi: 10.1194/jlr.M081745

PMCID:: PMC5928425

Abstract Article PDF–1.1M

Select item 44576536.

Acyl-CoA:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer’s disease mouse and reduces human P301L-tau content at the pre-symptomatic stage

Yohei Shibuya, Zhaoyang Niu, Elena Y. Bryleva, Brent T. Harris, Stephanie R. Murphy, Alireza Kheirollah, Zachary D. Bowen, Catherine C.Y. Chang, Ta-Yuan Chang

Neurobiol Aging. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Neurobiol Aging. 2015 Jul; 36(7): 2248–2259. Published online 2015 Apr 7. doi: 10.1016/j.neurobiolaging.2015.04.002

PMCID:: PMC4457653

Abstract Article PDF–4.2M

Select item 91701417.

Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells

Maximillian A. Rogers, Catherine C. Y. Chang, Robert A. Maue, Elaina M. Melton, Andrew A. Peden, William S. Garver, Junghoon Lee, Peter Schroen, Mitchell Huang, Ta-Yuan Chang

Proc Natl Acad Sci U S A. 2022 May 3; 119(18): e2201646119. Published online 2022 May 4. doi: 10.1073/pnas.2201646119

PMCID:: PMC9170141

Abstract Article PDF–2.7M

Select item 61710088.

Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity

Li-Hao Huang, Elaina M. Melton, Haibo Li, Paul Sohn, DaeYoung Jung, Ching-Yi Tsai, Tian Ma, Hiroyuki Sano, HyeKyung Ha, Randall H. Friedline, Jason K. Kim, Edward Usherwood, Catherine C. Y. Chang, Ta-Yuan Chang

Am J Physiol Endocrinol Metab. 2018 Sep 1; 315(3): E340–E356. Published online 2018 Mar 13. doi: 10.1152/ajpendo.00174.2017

PMCID:: PMC6171008

Abstract Article

Select item 38821169.

Acat1 Gene Ablation in Mice Increases Hematopoietic Progenitor Cell Proliferation in Bone Marrow and Causes Leukocytosis

Li-Hao Huang, Jingang Gui, Erika Artinger, Ruth Craig, Brent L. Berwin, Patricia A. Ernst, Catherine C.Y. Chang, Ta-Yuan Chang

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Sep; 33(9): 10.1161/ATVBAHA.112.301080. Published online 2013 Jul 11. doi: 10.1161/ATVBAHA.112.301080

PMCID:: PMC3882116

Abstract Article PDF–2.5M

Select item 19887410.

Increased atherosclerosis in LDL receptor–null mice lacking ACAT1 in macrophages

Sergio Fazio, Amy S. Major, Larry L. Swift, Linda A. Gleaves, Michel Accad, MacRae F. Linton, Robert V. Farese, Jr.

J Clin Invest. 2001 Jan 15; 107(2): 163–171. doi: 10.1172/JCI10310

PMCID:: PMC198874

Abstract Article PDF–312K

Select item 481354911.

Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression

Li-Hao Huang, Elaina M. Melton, Haibo Li, Paul Sohn, Maximillian A. Rogers, Mary Jo Mulligan-Kehoe, Steven N. Fiering, William F. Hickey, Catherine C. Y. Chang, Ta-Yuan Chang

J Biol Chem. 2016 Mar 18; 291(12): 6232–6244. Published online 2016 Jan 21. doi: 10.1074/jbc.M116.713818

PMCID:: PMC4813549

Abstract Article PDF–2.9M

Select item 445416512.

TLR4-mediated inflammation promotes foam cell formation of vascular smooth muscle cell by upregulating ACAT1 expression

Y-W Yin, S-Q Liao, M-J Zhang, Y Liu, B-H Li, Y Zhou, L Chen, C-Y Gao, J-C Li, L-L Zhang

Cell Death Dis. 2014 Dec; 5(12): e1574. Published online 2014 Dec 18. doi: 10.1038/cddis.2014.535

Correction in:: Cell Death Dis. 2015 Feb; 6(2): 1659.

PMCID:: PMC4454165

Abstract Article PDF–4.4M

Select item 336683913.

Cellular Pregnenolone Esterification by Acyl-CoA:Cholesterol Acyltransferase

Maximillian A. Rogers, Jay Liu, Mark M. Kushnir, Elena Bryleva, Alan L. Rockwood, A. Wayne Meikle, David Shapiro, Boris L. Vaisman, Alan T. Remaley, Catherine C. Y. Chang, Ta-Yuan Chang

J Biol Chem. 2012 May 18; 287(21): 17483–17492. Published online 2012 Apr 2. doi: 10.1074/jbc.M111.331306

PMCID:: PMC3366839

Abstract Article PDF–1.7M

Select item 284028614.

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

Elena Y. Bryleva, Maximillian A. Rogers, Catherine C.Y. Chang, Floyd Buen, Brent T. Harris, Estelle Rousselet, Nabil G. Seidah, Salvatore Oddo, Frank M. LaFerla, Thomas A. Spencer, William F. Hickey, Ta-Yuan Chang

Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7): 3081–3086. Published online 2010 Jan 26. doi: 10.1073/pnas.0913828107

PMCID:: PMC2840286

Abstract Article PDF–682K

Select item 640288415.

Loss of ACAT1 Attenuates Atherosclerosis Aggravated by Loss of NCEH1 in Bone Marrow-Derived Cells

Hisataka Yamazaki, Manabu Takahashi, Tetsuji Wakabayashi, Kent Sakai, Daisuke Yamamuro, Akihito Takei, Shoko Takei, Shuichi Nagashima, Hiroaki Yagyu, Motohiro Sekiya, Ken Ebihara, Shun Ishibashi

J Atheroscler Thromb. 2019 Mar 1; 26(3): 246–259. doi: 10.5551/jat.44040

PMCID:: PMC6402884

Abstract Article PDF–1.4M

Select item 736982316.

A Dipeptidyl Peptidase-4 Inhibitor Inhibits Foam Cell Formation of Macrophages in Type 1 Diabetes via Suppression of CD36 and ACAT-1 Expression

Michishige Terasaki, Hironori Yashima, Yusaku Mori, Tomomi Saito, Takanori Matsui, Munenori Hiromura, Hideki Kushima, Naoya Osaka, Makoto Ohara, Tomoyasu Fukui, Tsutomu Hirano, Sho-ichi Yamagishi

Int J Mol Sci. 2020 Jul; 21(13): 4811. Published online 2020 Jul 7. doi: 10.3390/ijms21134811

PMCID:: PMC7369823

Abstract Article PDF–991K

Select item 385668717.

Loss of β-carotene 15,15′-oxygenase in developing mouse tissues alters esterification of retinol, cholesterol and diacylglycerols

Joseph L. Dixon, Youn-Kyung Kim, Anita Brinker, Loredana Quadro

Biochim Biophys Acta. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Biochim Biophys Acta. 2014 Jan; 1841(1): 10.1016/j.bbalip.2013.08.013. Published online 2013 Aug 27. doi: 10.1016/j.bbalip.2013.08.013

PMCID:: PMC3856687

Abstract Article PDF–714K

Select item 440212218.

Tissue- and sex-specific effects of β-carotene 15,15′ oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice

Youn-Kyung Kim, Michael V. Zuccaro, Brianna K. Costabile, Rebeka Rodas, Loredana Quadro

Arch Biochem Biophys. Author manuscript; available in PMC 2016 Apr 15.

Published in final edited form as: Arch Biochem Biophys. 2015 Apr 15; 572: 11–18. Published online 2015 Jan 17. doi: 10.1016/j.abb.2015.01.002

PMCID:: PMC4402122

Abstract Article PDF–1.1M

Select item 394393219.

Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex

Jun Fan, Changliang Shan, Hee-Bum Kang, Shannon Elf, Jianxin Xie, Meghan Tucker, Ting-Lei Gu, Mike Aguiar, Scott Lonning, Huaibin Chen, Moosa Mohammadi, Laura-Mae P. Britton, Benjamin A. Garcia, Masa Aleckovic, Yibin Kang, Stefan Kaluz, Narra Devi, Erwin Van Meir, Taro Hitosugi, Jae Ho Seo, Sagar Lonial, Manila Gaddh, Martha Arellano, Hanna J. Khoury, Fadlo R. Khuri, Titus J. Boggon, Sumin Kang, Jing Chen

Mol Cell. Author manuscript; available in PMC 2015 Feb 20.

Published in final edited form as: Mol Cell. 2014 Feb 20; 53(4): 534–548. Published online 2014 Jan 30. doi: 10.1016/j.molcel.2013.12.026

PMCID:: PMC3943932

Abstract Article PDF–5.8M

Select item 574647520.

QTL Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant

Qimin Hai, Brian Ritchey, Peggy Robinet, Alexander M. Alzayed, Greg Brubaker, Jinying Zhang, Jonathan D. Smith

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 Jan; 38(1): 83–91. Published online 2017 Nov 2. doi: 10.1161/ATVBAHA.117.310173

PMCID:: PMC5746475

Abstract Article PDF–1002K

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