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Select item 105143601.

Glioblastoma cellular MAP4K1 facilitates tumor growth and disrupts T effector cell infiltration

Jin-Min Sun, Hong-Ye Fan, Yan Zhu, Ting-Ting Pan, Yong-Ping Wu, Dao-Yong Zhang, Xiao-Yu Hou

Life Sci Alliance. 2023 Dec; 6(12): e202301966. Published online 2023 Sep 21. doi: 10.26508/lsa.202301966

PMCID:: PMC10514360

Abstract Article PDF–4.9M

Select item 82394672.

MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway

Qing Ling, Fenglin Li, Xiang Zhang, Shihui Mao, Xiangjie Lin, Jiajia Pan, Wenle Ye, Wenwen Wei, Yu Qian, Chao Hu, Xin Huang, Jinghan Wang, Huafeng Wang, Jiansong Huang, Yungui Wang, Jie Jin

EBioMedicine. 2021 Jul; 69: 103441. Published online 2021 Jun 21. doi: 10.1016/j.ebiom.2021.103441

PMCID:: PMC8239467

Abstract Article PDF–5.1M

Select item 78055523.

Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1)

Wai L. Lau, Bradley Pearce, Heather Malakian, Iyoncy Rodrigo, Dianlin Xie, Mian Gao, Frank Marsilio, Chiehying Chang, Max Ruzanov, Jodi K. Muckelbauer, John A. Newitt, Daša Lipovšek, Steven Sheriff

Acta Crystallogr F Struct Biol Commun. 2021 Jan 1; 77(Pt 1): 22–28. Published online 2020 Dec 22. doi: 10.1107/S2053230X20016015

PMCID:: PMC7805552

Abstract Article PDF–865K

Select item 56470194.

HPK1 positive expression associated with longer overall survival in patients with estrogen receptor-positive invasive ductal carcinoma-not otherwise specified

Jiaojiao Wang, Lijie Song, Sen Yang, Weijie Zhang, Pengwei Lu, Shenglei Li, Huixiang Li, Liuxing Wang

Mol Med Rep. 2017 Oct; 16(4): 4634–4642. Published online 2017 Aug 2. doi: 10.3892/mmr.2017.7131

PMCID:: PMC5647019

Abstract Article PDF–1.4M

Select item 44032395.

Proteasome-Mediated Degradation and Functions of Hematopoietic Progenitor Kinase 1 in Pancreatic Cancer

Hua Wang, Xianzhou Song, Craig Logsdon, Guisheng Zhou, Douglas B. Evans, James L. Abbruzzese, Stanley R. Hamilton, Tse-Hua Tan, Huamin Wang

Cancer Res. Author manuscript; available in PMC 2015 Apr 20.

Published in final edited form as: Cancer Res. 2009 Feb 1; 69(3): 1063–1070. Published online 2009 Jan 13. doi: 10.1158/0008-5472.CAN-08-1751

PMCID:: PMC4403239

Abstract Article PDF–3.1M

Select item 33616436.

The pan-caspase inhibitor QVD has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells

Xiangwen Chen-Deutsch, Andrzej Kutner, Jonathan S Harrison, George P Studzinski

Leuk Res. Author manuscript; available in PMC 2013 Jul 1.

Published in final edited form as: Leuk Res. 2012 Jul; 36(7): 884–888. Published online 2012 Apr 26. doi: 10.1016/j.leukres.2012.03.023

PMCID:: PMC3361643

Abstract Article PDF–1.8M

Select item 33508777.

Dual role of hematopoietic progenitor kinase 1 (HPK1) as a positive regulator of 1α,25-dihydroxyvitamin D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin D resistance

Xiangwen Chen-Deutsch, George P Studzinski

Cell Cycle. 2012 Apr 1; 11(7): 1364–1373. Published online 2012 Apr 1. doi: 10.4161/cc.19765

PMCID:: PMC3350877

Abstract Article PDF–4.8M

Select item 32575678.

Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation

Rémi Lasserre, Céline Cuche, Ronnie Blecher-Gonen, Evgeny Libman, Elise Biquand, Anne Danckaert, Deborah Yablonski, Andrés Alcover, Vincenzo Di Bartolo

J Cell Biol. 2011 Nov 28; 195(5): 839–853. doi: 10.1083/jcb.201103105

PMCID:: PMC3257567

Abstract Article PDF–3.2M

Select item 21379179.

A novel pathway down-modulating T cell activation involves HPK-1–dependent recruitment of 14-3-3 proteins on SLP-76

Vincenzo Di Bartolo, Benjamin Montagne, Mogjiborahman Salek, Britta Jungwirth, Florent Carrette, Julien Fourtane, Nathalie Sol-Foulon, Frédérique Michel, Olivier Schwartz, Wolf D. Lehmann, Oreste Acuto

J Exp Med. 2007 Mar 19; 204(3): 681–691. doi: 10.1084/jem.20062066

PMCID:: PMC2137917

Abstract Article PDF–2.1M

Select item 106159510.

Activation of Hematopoietic Progenitor Kinase 1 Involves Relocation, Autophosphorylation, and Transphosphorylation by Protein Kinase D1

Rüdiger Arnold, Irene M. Patzak, Brit Neuhaus, Sadia Vancauwenbergh, André Veillette, Johan Van Lint, Friedemann Kiefer

Mol Cell Biol. 2005 Mar; 25(6): 2364–2383. doi: 10.1128/MCB.25.6.2364-2383.2005

PMCID:: PMC1061595

Abstract Article PDF–1.0M

Select item 703954411.

Hematopoietic progenitor kinase 1 down-regulates the oncogenic receptor tyrosine kinase AXL in pancreatic cancer

Xianzhou Song, Hironari Akasaka, Hua Wang, Reza Abbasgholizadeh, Ji-Hyun Shin, Fenglin Zang, Jiayi Chen, Craig D. Logsdon, Anirban Maitra, Andrew J. Bean, Huamin Wang

J Biol Chem. 2020 Feb 21; 295(8): 2348–2358. Published online 2020 Jan 20. doi: 10.1074/jbc.RA119.012186

PMCID:: PMC7039544

Abstract Article PDF–2.9M

Select item 136718012.

Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression To Suppress Colon Carcinoma Cell Invasion

Hsin-Sheng Yang, Connie P. Matthews, Timothy Clair, Qing Wang, Alyson R. Baker, Chou-Chi H. Li, Tse-Hua Tan, Nancy H. Colburn

Mol Cell Biol. 2006 Feb; 26(4): 1297–1306. doi: 10.1128/MCB.26.4.1297-1306.2006

PMCID:: PMC1367180

Abstract Article PDF–333K

Select item 372528113.

Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc

Qing Wang, Yan Zhang, Hsin-Sheng Yang

Biochim Biophys Acta. Author manuscript; available in PMC 2013 Oct 1.

Published in final edited form as: Biochim Biophys Acta. 2012 Oct; 1823(10): 1807–1814. Published online 2012 Jul 16. doi: 10.1016/j.bbamcr.2012.07.004

PMCID:: PMC3725281

Abstract Article PDF–2.4M

Select item 219349514.

B Cell Adaptor Containing Src Homology 2 Domain (Bash) Links B Cell Receptor Signaling to the Activation of Hematopoietic Progenitor Kinase 1

Sachiyo Tsuji, Mariko Okamoto, Koichi Yamada, Noriaki Okamoto, Ryo Goitsuka, Rudiger Arnold, Friedemann Kiefer, Daisuke Kitamura

J Exp Med. 2001 Aug 20; 194(4): 529–540. doi: 10.1084/jem.194.4.529

PMCID:: PMC2193495

Abstract Article PDF–307K

Select item 135633515.

Activation or suppression of NFκB by HPK1 determines sensitivity to activation-induced cell death

Dirk Brenner, Alexander Golks, Friedemann Kiefer, Peter H Krammer, Rüdiger Arnold

EMBO J. 2005 Dec 21; 24(24): 4279–4290. Published online 2005 Dec 8. doi: 10.1038/sj.emboj.7600894

PMCID:: PMC1356335

Abstract Article PDF–419K

Select item 12550716.

A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation

Stephen E. Girardin, Moshe Yaniv

EMBO J. 2001 Jul 2; 20(13): 3437–3446. doi: 10.1093/emboj/20.13.3437

PMCID:: PMC125507

Abstract Article PDF–308K

Select item 11606417.

Interaction of Hematopoietic Progenitor Kinase 1 with Adapter Proteins Crk and CrkL Leads to Synergistic Activation of c-Jun N-Terminal Kinase

Pin Ling, Zhengbin Yao, Christian F. Meyer, Xuhong Sunny Wang, Wolf Oehrl, Stephan M. Feller, Tse-Hua Tan

Mol Cell Biol. 1999 Feb; 19(2): 1359–1368. doi: 10.1128/mcb.19.2.1359

PMCID:: PMC116064

Abstract Article PDF–723K

Select item 273285018.

Phosphorylation of CARMA1 by HPK1 is critical for NF-κB activation in T cells

Dirk Brenner, Markus Brechmann, Simone Röhling, Myriam Tapernoux, Thomas Mock, Dominic Winter, Wolf D. Lehmann, Friedemann Kiefer, Margot Thome, Peter H. Krammer, Rüdiger Arnold

Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34): 14508–14513. Published online 2009 Aug 11. doi: 10.1073/pnas.0900457106