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Select item 76679811.

A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation

He-Qin Zhan, Mitra Najmi, Kai Lin, Srinivas Aluri, Andras Fiser, I. David Goldman, Rongbao Zhao

J Biol Chem. 2020 Nov 13; 295(46): 15650–15661. Published online 2020 Sep 6. doi: 10.1074/jbc.RA120.014757

PMCID:: PMC7667981

Abstract Article PDF–2.3M

Select item 65095032.

Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation

Srinivas Aluri, Rongbao Zhao, Kai Lin, Daniel Sanghoon Shin, Andras Fiser, I. David Goldman

J Biol Chem. 2019 May 3; 294(18): 7245–7258. Published online 2019 Mar 11. doi: 10.1074/jbc.RA118.005533

PMCID:: PMC6509503

Abstract Article PDF–2.4M

Select item 64156523.

Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7th and 8th helices of the proton-coupled folate transporter (SLC46A1)

Srinivas Aluri, Rongbao Zhao, Andras Fiser, I. David Goldman

Am J Physiol Cell Physiol. 2018 Mar 1; 314(3): C289–C296. Published online 2017 Nov 22. doi: 10.1152/ajpcell.00215.2017

PMCID:: PMC6415652

Abstract Article

Select item 62052904.

Evaluation of Proton-Coupled Folate Transporter (SLC46A1) Polymorphisms as Risk Factors for Neural Tube Defects and Oral Clefts

Julia E. VanderMeer, Tonia C. Carter, Faith Pangilinan, Adam Mitchell, Emma Kurnat-Thoma, Peadar N. Kirke, James F. Troendle, Anne M. Molloy, Ronald G. Munger, Marcia L. Feldkamp, Maria A. Mansilla, James L. Mills, Jeff C. Murray, Lawrence C. Brody

Am J Med Genet A. Author manuscript; available in PMC 2018 Oct 29.

Published in final edited form as: Am J Med Genet A. 2016 Apr; 170A(4): 1007–1016. Published online 2016 Jan 20. doi: 10.1002/ajmg.a.37539

PMCID:: PMC6205290

Abstract Article PDF–416K

Select item 57616285.

Hereditary folate malabsorption due to a mutation in the external gate of the proton-coupled folate transporter SLC46A1

Srinivas Aluri, Rongbao Zhao, Charlotte Lubout, Susanna M. I. Goorden, Andras Fiser, I. David Goldman

Blood Adv. 2018 Jan 9; 2(1): 61–68. Published online 2018 Jan 5. doi: 10.1182/bloodadvances.2017012690

PMCID:: PMC5761628

Abstract Article PDF–1.2M

Select item 56243256.

Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding

Srinivas Aluri, Rongbao Zhao, Andras Fiser, I David Goldman

Biochim Biophys Acta. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: Biochim Biophys Acta. 2017 Nov; 1859(11): 2193–2202. Published online 2017 Aug 9. doi: 10.1016/j.bbamem.2017.08.006

PMCID:: PMC5624325

Abstract Article PDF–834K

Select item 52530927.

The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption

Rongbao Zhao, Srinivas Aluri, I. David Goldman

Mol Aspects Med. Author manuscript; available in PMC 2018 Feb 1.

Published in final edited form as: Mol Aspects Med. 2017 Feb; 53: 57–72. Published online 2016 Sep 21. doi: 10.1016/j.mam.2016.09.002

PMCID:: PMC5253092

Abstract Article PDF–1.7M

Select item 49671328.

Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function

Mitra Najmi, Rongbao Zhao, Andras Fiser, I. David Goldman

Am J Physiol Cell Physiol. 2016 Jul 1; 311(1): C150–C157. Published online 2016 Jun 1. doi: 10.1152/ajpcell.00084.2016

PMCID:: PMC4967132

Abstract Article

Select item 48250189.

Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking

Rongbao Zhao, Mitra Najmi, Andras Fiser, I. David Goldman

J Biol Chem. 2016 Apr 8; 291(15): 8162–8172. Published online 2016 Feb 16. doi: 10.1074/jbc.M115.693929

PMCID:: PMC4825018

Abstract Article PDF–831K

Select item 471312010.

Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6

Mike R. Wilson, Sita Kugel, Jenny Huang, Lucas J. Wilson, Patrick A. Wloszczynski, Jun Ye, Larry H. Matherly, Zhanjun Hou

Biochem J. Author manuscript; available in PMC 2016 Jan 14.

Published in final edited form as: Biochem J. 2015 Jul 1; 469(1): 33–44. Published online 2015 Apr 16. doi: 10.1042/BJ20150169

PMCID:: PMC4713120

Abstract Article PDF–1.9M

Select item 439884711.

Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1)

Michele Visentin, Ersin Selcuk Unal, Mitra Najmi, Andras Fiser, Rongbao Zhao, I. David Goldman

Am J Physiol Cell Physiol. 2015 Apr 15; 308(8): C631–C641. Published online 2015 Jan 22. doi: 10.1152/ajpcell.00238.2014

PMCID:: PMC4398847

Abstract Article

Select item 415569012.

Substituted Cysteine Accessibility Reveals a Novel Transmembrane 2–3 Reentrant Loop and Functional Role for Transmembrane Domain 2 in the Human Proton-coupled Folate Transporter

Mike R. Wilson, Zhanjun Hou, Larry H. Matherly

J Biol Chem. 2014 Sep 5; 289(36): 25287–25295. Published online 2014 Jul 22. doi: 10.1074/jbc.M114.578252

PMCID:: PMC4155690

Abstract Article PDF–1.8M

Select item 393524113.

Prevalence of a Loss-of-Function Mutation in the Proton-Coupled Folate Transporter Gene (PCFT-SLC46A1) Causing Hereditary Folate Malabsorption in Puerto Rico

Kris M. Mahadeo, Ndeye Diop-Bove, Sonia I. Ramirez, Carmen L. Cadilla, Enid Rivera, Madelena Martin, Norma B. Lerner, Lisa DiAntonio, Salvatore Duva, Pedro J. Santiago-Borrero, I. David Goldman

J Pediatr. Author manuscript; available in PMC 2014 Feb 26.

Published in final edited form as: J Pediatr. 2011 Oct; 159(4): 623–7.e1. Published online 2011 Apr 13. doi: 10.1016/j.jpeds.2011.03.005