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Select item 111569381.

PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated fatty acids to facilitate hepatic secretion of large-sized very low-density lipoprotein

Scott M. Johnson, Hanmei Bao, Cailin E. McMahon, Yongbin Chen, Stephanie D. Burr, Aaron M. Anderson, Katja Madeyski-Bengtson, Daniel Lindén, Xianlin Han, Jun Liu

Nat Commun. 2024; 15: 4847. Published online 2024 Jun 6. doi: 10.1038/s41467-024-49224-x

PMCID:: PMC11156938

Abstract Article PDF–3.4M

Select item 65110162.

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

Soumik BasuRay, Yang Wang, Eriks Smagris, Jonathan C. Cohen, Helen H. Hobbs

Proc Natl Acad Sci U S A. 2019 May 7; 116(19): 9521–9526. Published online 2019 Apr 24. doi: 10.1073/pnas.1901974116

PMCID:: PMC6511016

Abstract Article PDF–1.0M

Select item 59368333.

Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets

Matthew A. Mitsche, Helen H. Hobbs, Jonathan C. Cohen

J Biol Chem. 2018 May 4; 293(18): 6958–6968. Published online 2018 Mar 19. doi: 10.1074/jbc.RA118.002333

Correction in:: J Biol Chem. 2018 Jun 15; 293(24): 9232.

PMCID:: PMC5936833

Abstract Article PDF–2.1M

Select item 34844614.

Chronic overexpression of PNPLA3^I148M in mouse liver causes hepatic steatosis

John Zhong Li, Yongcheng Huang, Ruchan Karaman, Pavlina T. Ivanova, H. Alex Brown, Thomas Roddy, Jose Castro-Perez, Jonathan C. Cohen, Helen H. Hobbs

J Clin Invest. 2012 Nov 1; 122(11): 4130–4144. Published online 2012 Oct 1. doi: 10.1172/JCI65179

PMCID:: PMC3484461

Abstract Article PDF–1.9M

Select item 29328635.

Pnpla3/adiponutrin deficiency in mice is not associated with fatty liver disease

Weiqin Chen, Benny Chang, Lan Li, Lawrence Chan

Hepatology. Author manuscript; available in PMC 2011 Sep 1.

Published in final edited form as: Hepatology. 2010 Sep; 52(3): 1134–1142. doi: 10.1002/hep.23812

Correction in:: volume 52 on page 2250

PMCID:: PMC2932863

Abstract Article PDF–866K

Select item 79246086.

Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice

Matteo Tardelli, Francesca V. Bruschi, Claudia D. Fuchs, Thierry Claudel, Nicole Auer, Victoria Kunczer, Onne A. H. O. Ronda, Henkjan J. Verkade, Tatjana Stojakovic, Hubert Scharnagl, Michael Trauner

Int J Mol Sci. 2021 Feb; 22(4): 2126. Published online 2021 Feb 20. doi: 10.3390/ijms22042126

PMCID:: PMC7924608

Abstract Article PDF–3.4M

Select item 66886067.

Identification of Phf16 and Pnpla3 as new adipogenic factors regulated by phytochemicals

Seo-Hyuk Chang, Ui Jeong Yun, Jin Hee Choi, Suji Kim, A Reum Lee, Dong Ho Lee, Min-Ju Seo, Vanja Panic, Claudio J. Villanueva, No-Joon Song, Kye Won Park

J Cell Biochem. Author manuscript; available in PMC 2019 Aug 9.

Published in final edited form as: J Cell Biochem. 2019 Mar; 120(3): 3599–3610. Published online 2018 Sep 11. doi: 10.1002/jcb.27637

PMCID:: PMC6688606

Abstract Article PDF–1.4M

Select item 64376358.

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

Daniel Lindén, Andrea Ahnmark, Piero Pingitore, Ester Ciociola, Ingela Ahlstedt, Anne-Christine Andréasson, Kavitha Sasidharan, Katja Madeyski-Bengtson, Magdalena Zurek, Rosellina M. Mancina, Anna Lindblom, Mikael Bjursell, Gerhard Böttcher, Marcus Ståhlman, Mohammad Bohlooly-Y, William G. Haynes, Björn Carlsson, Mark Graham, Richard Lee, Sue Murray, Luca Valenti, Sanjay Bhanot, Peter Åkerblad, Stefano Romeo

Mol Metab. 2019 Apr; 22: 49–61. Published online 2019 Feb 5. doi: 10.1016/j.molmet.2019.01.013

PMCID:: PMC6437635

Abstract Article PDF–3.8M

Select item 56053989.

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

Soumik BasuRay, Eriks Smagris, Jonathan C. Cohen, Helen H. Hobbs

Hepatology. 2017 Oct; 66(4): 1111–1124. Published online 2017 Aug 26. doi: 10.1002/hep.29273

PMCID:: PMC5605398

Abstract Article PDF–956K

Select item 553308610.

Binge alcohol alters PNPLA3 levels in liver through epigenetic mechanism involving histone H3 acetylation

Ricardo J. Restrepo, Robert W. Lim, Ronald J. Korthuis, Shivendra D. Shukla

Alcohol. Author manuscript; available in PMC 2017 Jul 28.

Published in final edited form as: Alcohol. 2017 May; 60: 77–82. Published online 2017 Mar 12. doi: 10.1016/j.alcohol.2017.01.009

PMCID:: PMC5533086

Abstract Article PDF–573K

Select item 426273511.

Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis

Eriks Smagris, Soumik BasuRay, John Li, Yongcheng Huang, Ka-man V Lai, Jesper Gromada, Jonathan C Cohen, Helen H Hobbs

Hepatology. 2015 Jan; 61(1): 108–118. Published online 2014 Oct 1. doi: 10.1002/hep.27242

PMCID:: PMC4262735

Abstract Article PDF–1.1M

Select item 302355212.

Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome

Mahesh K. Basantani, Mitch T. Sitnick, Lingzhi Cai, Daniel S. Brenner, Noah P. Gardner, John Zhong Li, Gabriele Schoiswohl, Kui Yang, Manju Kumari, Richard W. Gross, Rudolf Zechner, Erin E. Kershaw

J Lipid Res. 2011 Feb; 52(2): 318–329. doi: 10.1194/jlr.M011205

PMCID:: PMC3023552

Abstract Article PDF–783K

Select item 281917813.

Adipose Triglyceride Lipase: Function, Regulation by Insulin, and Comparison With Adiponutrin

Erin E. Kershaw, Jonathan K. Hamm, Linda A.W. Verhagen, Odile Peroni, Masa Katic, Jeffrey S. Flier

Diabetes. Author manuscript; available in PMC 2010 Feb 10.

Published in final edited form as: Diabetes. 2006 Jan; 55(1): 148.

PMCID:: PMC2819178

Abstract Article PDF–1.4M

Select item 336170814.

Adiponutrin Functions as a Nutritionally Regulated Lysophosphatidic Acid Acyltransferase

Manju Kumari, Gabriele Schoiswohl, Chandramohan Chitraju, Margret Paar, Irina Cornaciu, Ashraf Y. Rangrez, Nuttaporn Wongsiriroj, Harald M. Nagy, Pavlina T. Ivanova, Sarah A. Scott, Oskar Knittelfelder, Gerald N. Rechberger, Ruth Birner-Gruenberger, Sandra Eder, H. Alex Brown, Guenter Haemmerle, Monika Oberer, Achim Lass, Erin E. Kershaw, Robert Zimmermann, Rudolf Zechner

Cell Metab. Author manuscript; available in PMC 2013 May 2.

Published in final edited form as: Cell Metab. 2012 May 2; 15(5): 691–702. doi: 10.1016/j.cmet.2012.04.008

PMCID:: PMC3361708

Abstract Article PDF–2.2M

Select item 255627015.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

Select item 357241016.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 28355417.

Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

Brian P. Zambrowicz, Alejandro Abuin, Ramiro Ramirez-Solis, Lizabeth J. Richter, James Piggott, Hector BeltrandelRio, Eric C. Buxton, Joel Edwards, Rick A. Finch, Carl J. Friddle, Anupma Gupta, Gwenn Hansen, Yi Hu, Wenhu Huang, Crystal Jaing, Billie Wayne Key, Jr., Peter Kipp, Buckley Kohlhauff, Zhi-Qing Ma, Diane Markesich, Robert Payne, David G. Potter, Ny Qian, Joseph Shaw, Jeff Schrick, Zheng-Zheng Shi, Mary Jean Sparks, Isaac Van Sligtenhorst, Peter Vogel, Wade Walke, Nianhua Xu, Qichao Zhu, Christophe Person, Arthur T. Sands

Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24): 14109–14114. Published online 2003 Nov 10. doi: 10.1073/pnas.2336103100

Correction in:: Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12): 4332.

PMCID:: PMC283554

Abstract Article PDF–481K

Select item 302253418.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 52892819.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 31099220.

RIKEN Integrated Sequence Analysis (RISA) System—384-Format Sequencing Pipeline with 384 Multicapillary Sequencer

Kazuhiro Shibata, Masayoshi Itoh, Katsunori Aizawa, Sumiharu Nagaoka, Nobuya Sasaki, Piero Carninci, Hideaki Konno, Junichi Akiyama, Katsuo Nishi, Tokuji Kitsunai, Hideo Tashiro, Mari Itoh, Noriko Sumi, Yoshiyuki Ishii, Shin Nakamura, Makoto Hazama, Tsutomu Nishine, Akira Harada, Rintaro Yamamoto, Hiroyuki Matsumoto, Sumito Sakaguchi, Takashi Ikegami, Katsuya Kashiwagi, Syuji Fujiwake, Kouji Inoue, Yoshiyuki Togawa, Masaki Izawa, Eiji Ohara, Masanori Watahiki, Yuko Yoneda, Tomokazu Ishikawa, Kaori Ozawa, Takumi Tanaka, Shuji Matsuura, Jun Kawai, Yasushi Okazaki, Masami Muramatsu, Yorinao Inoue, Akira Kira, Yoshihide Hayashizaki

Genome Res. 2000 Nov; 10(11): 1757–1771. doi: 10.1101/gr.152600

PMCID:: PMC310992

Abstract Article PDF–3.4M

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