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Items: 1 to 20 of 39

1.
The roles of PIKE in tumorigenesis
Qi Qi, Keqiang Ye
Acta Pharmacol Sin. 2013 Aug 5; 34(8): 991–997. Published online 2013 Jun 17. doi: 10.1038/aps.2013.71
PMCID:
PMC3733165
AbstractArticlePDF–369K
2.
Frequent Heterogeneous Missense Mutations of GGAP2 in Prostate Cancer: Implications for Tumor Biology, Clonality and Mutation Analysis
Yi Cai, Jianghua Wang, Chengxi Ren, Michael Ittmann
PLoS One. 2012; 7(2): e32708. Published online 2012 Feb 28. doi: 10.1371/journal.pone.0032708
PMCID:
PMC3289671
AbstractArticlePDF–180K
3.
AGAP2 regulates retrograde transport between early endosomes and the TGN
Yoko Shiba, Winfried Römer, Gonzalo A. Mardones, Patricia V. Burgos, Christophe Lamaze, Ludger Johannes
J Cell Sci. 2010 Jul 15; 123(14): 2381–2390. Published online 2010 Jun 15. doi: 10.1242/jcs.057778
PMCID:
PMC2894655
AbstractArticle
4.
The centaurin γ-1 GTPase-like domain functions as an NTPase
Meera Soundararajan, Xiaowen Yang, Jonathan M. Elkins, Frank Sobott, Declan A. Doyle
Biochem J. 2007 Feb 1; 401(Pt 3): 679–688. Prepublished online 2006 Oct 12. Published online 2007 Jan 12. doi: 10.1042/BJ20060555
PMCID:
PMC1770848
AbstractArticlePDF–566K
5.
PIKE GTPase Signaling and Function
Jee-Yin Ahn, Keqiang Ye
Int J Biol Sci. 2005; 1(2): 44–50. Published online 2005 Apr 1. doi: 10.7150/ijbs.1.44
PMCID:
PMC1142212
AbstractArticlePDF–742K
6.
SP1 and RARα regulate AGAP2 expression in cancer
Yegor Doush, Arif A. Surani, Amaia Navarro-Corcuera, Stephanie McArdle, E. Ellen Billett, Cristina Montiel-Duarte
Sci Rep. 2019; 9: 390. Published online 2019 Jan 23. doi: 10.1038/s41598-018-36888-x
PMCID:
PMC6344547
AbstractArticlePDF–3.2M
7.
Arf GTPase-activating Protein AGAP2 Regulates Focal Adhesion Kinase Activity and Focal Adhesion Remodeling
Yunjuan Zhu, Yuanjun Wu, Jae I. Kim, Zhimin Wang, Yehia Daaka, Zhongzhen Nie
J Biol Chem. 2009 May 15; 284(20): 13489–13496. doi: 10.1074/jbc.M900469200
PMCID:
PMC2679449
AbstractArticlePDF–694K
8.
GGAP2/PIKE-A directly activates both the Akt and NF-κB pathways and promotes prostate cancer progression
Yi Cai, Jianghua Wang, Rile Li, Gustavo Ayala, Michael Ittmann, Mingyao Liu
Cancer Res. Author manuscript; available in PMC 2010 Feb 1.
Published in final edited form as: Cancer Res. 2009 Feb 1; 69(3): 819–827. Published online 2009 Jan 27. doi: 10.1158/0008-5472.CAN-08-2537
PMCID:
PMC2668918
AbstractArticlePDF–3.7M
9.
Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings
Yuanxin Hu, Zhixue Liu, Keqiang Ye
Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46): 16853–16858. Published online 2005 Nov 1. doi: 10.1073/pnas.0507365102
PMCID:
PMC1283830
AbstractArticlePDF–586K
10.
PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt
Jee-Yin Ahn, Yuanxin Hu, Todd G. Kroll, Paulette Allard, Keqiang Ye
Proc Natl Acad Sci U S A. 2004 May 4; 101(18): 6993–6998. Published online 2004 Apr 26. doi: 10.1073/pnas.0400921101
PMCID:
PMC406454
AbstractArticlePDF–566K
11.
Exosomes derived from microRNA-199a-overexpressing mesenchymal stem cells inhibit glioma progression by down-regulating AGAP2
Lei Yu, Si Gui, Yawei Liu, Xiaoyu Qiu, Guozhong Zhang, Xi’an Zhang, Jun Pan, Jun Fan, Songtao Qi, Binghui Qiu
Aging (Albany NY) 2019 Aug 15; 11(15): 5300–5318. Published online 2019 Aug 5. doi: 10.18632/aging.102092
PMCID:
PMC6710058
AbstractArticlePDF–3.5M
12.
Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity
S Zhang, Q Qi, C B Chan, W Zhou, J Chen, H R Luo, C Appin, D J Brat, K Ye
Cell Death Differ. 2016 Jan; 23(1): 52–63. Published online 2015 May 22. doi: 10.1038/cdd.2015.66
PMCID:
PMC4815978
AbstractArticlePDF–2.0M
13.
The Arf GAP AGAP2 interacts with β-arrestin2 and regulates β2-adrenergic receptor recycling and ERK activation
Yuanjun Wu, Yu Zhao, Xiaojie Ma, Yunjuan Zhu, Jaimin Patel, Zhongzhen Nie
Biochem J. Author manuscript; available in PMC 2014 Mar 13.
Published in final edited form as: Biochem J. 2013 Jun 15; 452(3): 411–421. doi: 10.1042/BJ20121004
PMCID:
PMC3952494
AbstractArticlePDF–1.2M
14.
Disrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion and colony formation
Q Qi, K He, X Liu, C Pham, C Meyerkord, H Fu, K Ye
Oncogene. Author manuscript; available in PMC 2013 Oct 25.
Published in final edited form as: Oncogene. 2013 Feb 21; 32(8): 10.1038/onc.2012.109. Published online 2012 Mar 26. doi: 10.1038/onc.2012.109
PMCID:
PMC3808079
AbstractArticlePDF–3.0M
15.
Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner
Kunyan He, Sung-Wuk Jang, Jayashree Joshi, Min-Heui Yoo, Keqiang Ye
Mol Biol Cell. 2011 Jun 1; 22(11): 1943–1954. doi: 10.1091/mbc.E10-11-0923
PMCID:
PMC3103409
AbstractArticlePDF–1.4M
16.
Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion
Ren Liu, Bo Tian, Marla Gearing, Stephen Hunter, Keqiang Ye, Zixu Mao
Proc Natl Acad Sci U S A. 2008 May 27; 105(21): 7570–7575. Published online 2008 May 16. doi: 10.1073/pnas.0712306105
PMCID:
PMC2396674
AbstractArticlePDF–1.2M
17.
M-T5, the Ankyrin Repeat, Host Range Protein of Myxoma Virus, Activates Akt and Can Be Functionally Replaced by Cellular PIKE-A
Steven J. Werden, John W. Barrett, Gen Wang, Marianne M. Stanford, Grant McFadden
J Virol. 2007 Mar; 81(5): 2340–2348. Published online 2006 Dec 6. doi: 10.1128/JVI.01310-06
PMCID:
PMC1865929
AbstractArticlePDF–465K
18.
Co-amplification of Phosphoinositide 3-kinase enhancer A and Cyclin-dependent kinase 4 Triggers Glioblastoma Progression
Qi Qi, Seong-Su Kang, Shuai Zhang, Cau Pham, Haian Fu, Daniel J. Brat, Keqiang Ye
Oncogene. Author manuscript; available in PMC 2017 Oct 3.
Published in final edited form as: Oncogene. 2017 Aug 10; 36(32): 4562–4572. Published online 2017 Apr 3. doi: 10.1038/onc.2017.67
PMCID:
PMC5552418
AbstractArticlePDF–2.2M
19.
α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation
Seong Su Kang, Zhentao Zhang, Xia Liu, Fredric P. Manfredsson, Li He, P. Michael Iuvone, Xuebing Cao, Yi E. Sun, Lingjing Jin, Keqiang Ye
Proc Natl Acad Sci U S A. 2017 Jan 31; 114(5): 1183–1188. Published online 2017 Jan 17. doi: 10.1073/pnas.1618627114
PMCID:
PMC5293033
AbstractArticlePDF–1.2M
20.
The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity
Chi Bun Chan, Xia Liu, Kunyan He, Qi Qi, Dae Y Jung, Jason K Kim, Keqiang Ye
EMBO Rep. 2011 Aug; 12(8): 847–854. Published online 2011 Jul 1. doi: 10.1038/embor.2011.108
PMCID:
PMC3147257
AbstractArticlePDF–1.0M

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