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Items: 1 to 20 of 121

1.
Mismatch repair protein MLH1 suppresses replicative stress in BRCA2-deficient breast tumors
Satheesh K. Sengodan, Xiaoju Hu, Vaishnavi Peddibhotla, Kuppusamy Balamurugan, Alexander Y. Mitrophanov, Lois McKennett, Suhas S. Kharat, Rahul Sanawar, Vinod Kumar Singh, Mary E. Albaugh, Sandra S. Burkett, Yongmei Zhao, Bao Tran, Tyler Malys, Esta Sterneck, Subhajyoti De, Shyam K. Sharan
J Clin Invest. 2024 Apr 1; 134(7): e173718. Published online 2024 Jan 25. doi: 10.1172/JCI173718
PMCID:
PMC10977984
AbstractArticlePDF–3.6M
2.
Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant
Arun Prakash Mishra, Suzanne Hartford, Rajani Kant Chittela, Sounak Sahu, Suhas S. Kharat, Lucia Alvaro-Aranda, Aida Contreras-Perez, Teresa Sullivan, Betty K. Martin, Mary Albaugh, Eileen Southon, Sandra Burkett, Baktiar Karim, Aura Carreira, Lino Tessarollo, Shyam K. Sharan
Cell Death Dis. 2023 Nov; 14(11): 753. Published online 2023 Nov 18. doi: 10.1038/s41419-023-06289-8
PMCID:
PMC10657400
AbstractArticlePDF–3.2M
3.
A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer
EunJung Lee, Suyakarn Archasappawat, Keely Ji, Jocelyn Pena, Virneliz Fernandez-Vega, Ritika Gangaraju, Nitin Sai Beesabathuni, Martin Jean Kim, Qi Tian, Priya S. Shah, Louis Scampavia, Timothy P. Spicer, Chang-Il Hwang
Cell Death Dis. 2023 Sep; 14(9): 620. Published online 2023 Sep 21. doi: 10.1038/s41419-023-06145-9
PMCID:
PMC10514057
AbstractArticlePDF–3.7M
4.
A transcriptional response to replication stress selectively expands a subset of Brca2-mutant mammary epithelial cells
Maryam Ghaderi Najafabadi, G. Kenneth Gray, Li Ren Kong, Komal Gupta, David Perera, Huw Naylor, Joan S. Brugge, Ashok R. Venkitaraman, Mona Shehata
Nat Commun. 2023; 14: 5206. Published online 2023 Aug 25. doi: 10.1038/s41467-023-40956-w
PMCID:
PMC10457340
AbstractArticlePDF–6.7M
5.
Interplay between Fanconi anemia and homologous recombination pathways in genome integrity
Johanna Michl, Jutta Zimmer, Madalena Tarsounas
EMBO J. 2016 May 2; 35(9): 909–923. Published online 2016 Apr 1. doi: 10.15252/embj.201693860
PMCID:
PMC4865030
AbstractArticlePDF–455K
6.
Brca2 Deficiency Leads to T Cell Loss and Immune Dysfunction
Jun-hyeon Jeong, Areum Jo, Pilgu Park, Hyunsook Lee, Hae-Ock Lee
Mol Cells. 2015 Mar 31; 38(3): 251–258. Published online 2015 Feb 4. doi: 10.14348/molcells.2015.2302
PMCID:
PMC4363725
AbstractArticlePDF–2.6M
7.
Deletion of BRCA2 exon 27 causes defects in response to both stalled and collapsed replication forks
Tae Moon Kim, Mi Young Son, Sherry Dodds, Lingchuan Hu, Paul Hasty
Mutat Res. Author manuscript; available in PMC 2015 Aug 1.
Published in final edited form as: Mutat Res. 2014 August-September; 766-767: 66–72. Published online 2014 Jun 22. doi: 10.1016/j.mrfmmm.2014.06.003
PMCID:
PMC4136705
AbstractArticlePDF–1.1M
8.
BRCA2 Protein Deficiency Exaggerates Doxorubicin-induced Cardiomyocyte Apoptosis and Cardiac Failure
Krishna K. Singh, Praphulla C. Shukla, Adrian Quan, Jean-François Desjardins, Fina Lovren, Yi Pan, Vinay Garg, Sumandeep Gosal, Ankit Garg, Paul E. Szmitko, Michael D. Schneider, Thomas G. Parker, William L. Stanford, Howard Leong-Poi, Hwee Teoh, Mohammed Al-Omran, Subodh Verma
J Biol Chem. 2012 Feb 24; 287(9): 6604–6614. Published online 2011 Dec 8. doi: 10.1074/jbc.M111.292664
PMCID:
PMC3325595
AbstractArticlePDF–2.2M
9.
Inactivation of Brca2 cooperates with Trp53R172H to induce invasive pancreatic ductal adenocarcinomas in mice: A mouse model of familial pancreatic cancer
Georg Feldmann, Collins Karikari, Marco dal Molin, Stephanie Duringer, Petra Volkmann, Detlef K Bartsch, Savita Bisht, Jan-Bart Koorstra, Peter Brossart, Anirban Maitra, Volker Fendrich
Cancer Biol Ther. 2011 Jun 1; 11(11): 959–968. Published online 2011 Jun 1. doi: 10.4161/cbt.11.11.15534
PMCID:
PMC3127047
AbstractArticlePDF–4.5M
10.
Development of thymic lymphomas in mice disrupted of Brca2 allele in the thymus
Pil-Gu Park, Hyunsook Lee
Exp Mol Med. 2008 Jun 30; 40(3): 339–344. Published online 2008 Jun 20. doi: 10.3858/emm.2008.40.3.339
PMCID:
PMC2679290
AbstractArticlePDF–1.9M
11.
Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation
Andrew N.J. Tutt, Conny Th.M. van Oostrom, Gillian M. Ross, Harry van Steeg, Alan Ashworth
EMBO Rep. 2002 Mar 15; 3(3): 255–260. doi: 10.1093/embo-reports/kvf037
PMCID:
PMC1084010
AbstractArticlePDF–399K
12.
Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress
Karl-Heinz Tomaszowski, Sunetra Roy, Carolina Guerrero, Poojan Shukla, Caezaan Keshvani, Yue Chen, Martina Ott, Xiaogang Wu, Jianhua Zhang, Courtney D. DiNardo, Detlev Schindler, Katharina Schlacher
Nat Commun. 2023; 14: 1333. Published online 2023 Mar 11. doi: 10.1038/s41467-023-36933-y
Correction in:
Nat Commun. 2024; 15: 2214.
PMCID:
PMC10008622
AbstractArticlePDF–3.0M
13.
BRCA2-DSS1 interaction is dispensable for RAD51 recruitment at replication-induced and meiotic DNA double strand breaks
Arun Prakash Mishra, Suzanne A. Hartford, Sounak Sahu, Kimberly Klarmann, Rajani Kant Chittela, Kajal Biswas, Albert B. Jeon, Betty K. Martin, Sandra Burkett, Eileen Southon, Susan Reid, Mary E. Albaugh, Baktiar Karim, Lino Tessarollo, Jonathan R. Keller, Shyam K. Sharan
Nat Commun. 2022; 13: 1751. Published online 2022 Apr 1. doi: 10.1038/s41467-022-29409-y
PMCID:
PMC8975877
AbstractArticlePDF–4.8M
14.
Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair
Maarten W Paul, Arshdeep Sidhu, Yongxin Liang, Sarah E van Rossum-Fikkert, Hanny Odijk, Alex N Zelensky, Roland Kanaar, Claire Wyman
eLife. 2021; 10: e67926. Published online 2021 Jul 13. doi: 10.7554/eLife.67926
PMCID:
PMC8324294
AbstractArticlePDF–3.0M
15.
Epidemiological and ES cell-based Functional Evaluation of BRCA2 Variants Identified in Families with Breast Cancer
Teresa Sullivan, Eswary Thirthagiri, Chan-Eng Chong, Stacey Stauffer, Susan Reid, Eileen Southon, Tiara Hassan, Aravind Ravichandran, Eldarina Wijaya, Joanna Lim, Nur Aishah Mohd Taib, Farhana Fadzli, Cheng Har Yip, Mikael Hartman, Jingmei Li, Rob M. van Dam, SGBCC Investigators, MYBRCA Investigators, Susan L. North, Ranabir Das, Douglas F. Easton, Kajal Biswas, Soo-Hwang Teo, Shyam K. Sharan
Hum Mutat. Author manuscript; available in PMC 2022 Feb 1.
Published in final edited form as: Hum Mutat. 2021 Feb; 42(2): 200–212. Published online 2020 Dec 31. doi: 10.1002/humu.24154
PMCID:
PMC7919386
AbstractArticlePDF–666K
16.
Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C
Xiaomin Chen, Fangfei Peng, Yan Ji, Honggang Xiang, Xiang Wang, Tingting Liu, Heng Wang, Yumin Han, Changxu Wang, Yongfeng Zhang, Xiangyin Kong, Jing-Yu Lang
Cell Death Dis. 2020 Sep; 11(9): 812. Published online 2020 Sep 26. doi: 10.1038/s41419-020-03013-8
PMCID:
PMC7519908
AbstractArticlePDF–2.3M
17.
Calibration of pathogenicity due to variant-induced leaky splicing defects by using BRCA2 exon 3 as a model system
Hélène Tubeuf, Sandrine M. Caputo, Teresa Sullivan, Julie Rondeaux, Sophie Krieger, Virginie Caux-Moncoutier, Julie Hauchard, Gaia Castelain, Alice Fiévet, Laëtitia Meulemans, Françoise Révillion, Mélanie Léoné, Nadia Boutry-Kryza, Capucine Delnatte, Marine Guillaud-Bataille, Linda Cleveland, Susan Reid, Eileen Southon, Omar Soukarieh, Aurélie Drouet, Daniela Di Giacomo, Myriam Vezain, Françoise Bonnet-Dorion, Violaine Bourdon, Hélène Larbre, Danièle Muller, Pascal Pujol, Fátima Vaz, Séverine Audebert-Bellanger, Chrystelle Colas, Laurence Venat-Bouvet, Angela R. Solano, Dominique Stoppa-Lyonnet, Claude Houdayer, Thierry Frebourg, Pascaline Gaildrat, Shyam K Sharan, Alexandra Martins
Cancer Res. Author manuscript; available in PMC 2021 Mar 1.
Published in final edited form as: Cancer Res. 2020 Sep 1; 80(17): 3593–3605. Published online 2020 Jul 8. doi: 10.1158/0008-5472.CAN-20-0895
PMCID:
PMC7484206
AbstractArticlePDF–1.4M
18.
BRCA2 deficiency is a potential driver for human primary ovarian insufficiency
Yilong Miao, Pan Wang, Bingteng Xie, Mo Yang, Sen Li, Zhaokang Cui, Yong Fan, Mo Li, Bo Xiong
Cell Death Dis. 2019 Jul; 10(7): 474. Published online 2019 Jun 17. doi: 10.1038/s41419-019-1720-0
PMCID:
PMC6572856
AbstractArticlePDF–4.2M
19.
Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours
Liliana D. Ordonez, Trevor Hay, Robert McEwen, Urszula M. Polanska, Adina Hughes, Oona Delpuech, Elaine Cadogan, Steve Powell, Jonathan Dry, Giusy Tornillo, Lucy Silcock, Elisabetta Leo, Mark J. O’Connor, Alan R. Clarke, Matthew J. Smalley
Oncotarget. 2019 Apr 5; 10(27): 2586–2606. Published online 2019 Apr 5. doi: 10.18632/oncotarget.26830
PMCID:
PMC6498996
AbstractArticlePDF–6.5M
20.
BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination
Weiran Feng, Maria Jasin
Nat Commun. 2017; 8: 525. Published online 2017 Sep 13. doi: 10.1038/s41467-017-00634-0
PMCID:
PMC5597640
AbstractArticlePDF–2.8M

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